Acral porokeratosis associated with anonychia

Rajesh, Gurumoorthy; P, Devan P; Subramaniam, Keerthi; Karthikeyan, Kaliaperumal

doi:10.4103/ijdvl.ijdvl_940_16

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Ungual PK is very rarely described [2-12]. All previously reported cases of ungual PK are characterized by chronicity and tendency toward nail apparatus scarring with tendency to destruction of the nail plate.…”

Section: Pk Affecting the Nailsmentioning

confidence: 99%

Porokeratosis of the Nail Unit: Case Series and Review

Yendo

Gabbi

Nico³

2021

Skin Appendage Disord

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Background: The lesions of porokeratosis (PK) lead to skin atrophy and scarring as long as they spread centrifugally. PK affecting the nail unit is seldom described. Objective: The aim was to revise the previously reported cases of ungual PK and to present 3 new cases. Methods: A PubMed search was performed with the keywords “nail” and “porokeratosis.” Previously reported cases as well as 3 new cases are depicted in tables. Results: Only 11 cases of ungual PK were found; 3 new cases have been added. All patients presented with typical lesions of PK (Mibelli, isolated, segmental, or ostial eccrine types) that happened to affect nails due to nail matrix or nail bed compromise, resulting in mild to severe nail scarring, including irreversible anonychia. The present 3 case series contrast with the previous single case reports. Conclusions: PK affecting the nails is exceedingly rare. Changes in nails affected by PK are irreversible, since, as on the skin, this is a chronic scarring process.

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Section: Pk Affecting the Nailsmentioning

confidence: 99%

Porokeratosis of the Nail Unit: Case Series and Review

Yendo

Gabbi

Nico³

2021

Skin Appendage Disord

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Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Acral porokeratosis associated with anonychia

Cited by 2 publications

References 2 publications

Porokeratosis of the Nail Unit: Case Series and Review

Porokeratosis of the Nail Unit: Case Series and Review

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

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