Acral myxoinflammatory fibroblastic sarcoma

Abstract

Acral myxoinflammatory fibroblastic sarcoma is a rare low-grade malignant soft tissue tumor, usually observed in the extremities of middle-aged patients. We report a case involving the third finger of the left hand of a middle-aged man. The tumor showed a nodular architecture, with cellular areas, occasional foci of hyalinized fibrosis, and hypocellular areas with a myxoid background. Various neoplastic cells were identified including spindled or rounded epithelioid cells and occasional bizarre giant cells, morphologically mimicking ganglion cells. Tumor cells were strongly immunoreactive for vimentin and variably positive for CD68 and CD34. The tumor was completely removed, without further treatment.

A case of lung metastasis in myxoinflammatory fibroblastic sarcoma: analytical review of one hundred and thirty eight cases

“…Regarding tumour location, initial reports overemphasised the predilection for distal extremities, so the term acral myxoinflammatory fibroblastic sarcoma was coined [2]. Although the adjective acral was deleted from the official nomenclature in 2002 because some cases are located axially [3], its use is still common [19,20,26,28,29,32,34,36,39,45]. Our analysis confirms that distal extremities are involved in the majority of cases, with hands and fingers being the most common sites.…”

Fleshy Polypoidal Painless Subungual Mass of the Thumb

“…Digital myxoid pseudocyst and distal digital subungual keratoacanthoma may also mimic the clinical picture of SAFM but with distinct histopathology. The cutaneous and histopathologic features of these diseases are summarized in a table (Table 1) [2,5,[7][8][9].…”

Myxoinflammatory fibroblastic sarcoma of the thigh: A morphologic diversity

“…[45] Since then about 100 cases have been reported. [5] Clinically it develops in patients of all ages and presents as a mass in the distal extremities, most frequently in the fingers and usually within the subcutaneous tissue.…”

“…[45] Since then about 100 cases have been reported. [5] Clinically it develops in patients of all ages and presents as a mass in the distal extremities, most frequently in the fingers and usually within the subcutaneous tissue. [6] It is now known that this tumor can occur more proximally and the term ′acral′ has been dropped in 2002 WHO classification.…”

“…[5] Inflammatory myofibroblastic tumor and inflammatory fibrosarcoma commonly occur in the abdomen and thorax in contrast to MIFS. Cells of MIFS are more bizarre and lack histochemical features of myofibroblasts.…”