Acral BRAF‐mutated tubular adenoma should be distinguished from HPV42‐related digital papillary adenocarcinoma

Abstract

We read the article entitled "Two distinct pathogenic pathways of digital papillary adenocarcinoma -BRAF mutation or low-risk HPV infection," which was recently published in your journal, and would like to share our thoughts on the findings to avoid confusion in skin tumor nomenclature and prevent potential harm to patients from misdiagnosis.Digital papillary adenocarcinoma (DPA) is a rare sweat gland carcinoma capable of metastasis. It almost exclusively arises at acral sites. 1,2