Acquisition of cytomegalovirus infection: an update.

Forbes, B A

doi:10.1128/cmr.2.2.204-216.1989

Cited by 3 publications

(3 citation statements)

References 109 publications

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“…After delivery, saliva may be the most common way for the virus to spread. Inadequate sanitation is most likely the mechanism through which the virus is spread early in life among babies and young children (19) . On the other hand, it appears that later in life, at reproductive age, urban sexual transmission is the major route of infection.…”

Section: Discussionmentioning

confidence: 99%

Immunological Indicators in Aborted Women Infected with Human Cytomegalovirus in Karbala City, Iraq

Alkharsan¹,

Aljanabi²,

Alshammari³

2022

The Egyptian Journal of Hospital Medicine

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Introduction:In affluent countries, human cytomegalovirus (CMV) is the most common cause of congenital malformations caused by viral intrauterine infection. HCMV infection is the infectious cause of deafness, visual loss, mental retardation, and other neurodevelopmental disorders in children, causing significant morbidity and mortality in infants. Objective: The work was conducted to identify the rates of spontaneous abortion occurrence among the age groups, stages of pregnancy, and detection of the type of abortion that most frequently occurred in the pregnant women community. Patients and Methods: 65 Blood samples were collected from abortifacients women at the moment of miscarriage. Each pregnant woman had five milliliters of blood collected to separate the sera. The CMV-IgM and CMV-IgG antibody levels in the patient's serum were determined using an ELISA assay. Results: The outcome of antibodies against CMV were found in 50 of 65 (76.92%) aborted mothers, while 15 (23.07%) of 65 women had abortions for unknown reasons. Meanwhile, most pregnant women who had abortions tested positive for CMV-IgG, with 36 (72%) of them being positive, the number of people who tested positive for CMV-IgM was 14 (28%). The age group 25-34 years old was the most infected with CMV infection, accounting for 25 (50%) of the cases. 96% and 4% of patients were infected in urban and the countryside regions, respectively. Conclusion:Based on this research, spontaneous abortion rates are increasing within young age groups, particularly for missed abortions during the first trimester of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Immunological Indicators in Aborted Women Infected with Human Cytomegalovirus in Karbala City, Iraq

Alkharsan¹,

Aljanabi²,

Alshammari³

2022

The Egyptian Journal of Hospital Medicine

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“…Cytomegalovirus is most commonly transmitted through kissing and sexual intercourse. It can also be transferred from an infected mother to her unborn child (fetus, embryo) (1,2,7,10,12). This virus is often "silent" because the signs and symptoms cannot be felt by the person infected (19)(20)(21).…”

mentioning

confidence: 99%

“…This virus is often "silent" because the signs and symptoms cannot be felt by the person infected (19)(20)(21). However, it can cause life-threatening illness in infants, HIV patients, transplant recipients, and those with weak immune systems (3,5,6,7,17). For those with weak immune systems, cytomegalovirus can cause more serious illnesses such as inflammations of the retina and pneumonia, esophagus, liver, large intestine, and brain disorder (3,5,17).…”

mentioning

confidence: 99%

Cytomegalovirus PCR Analysis of Serum and Ocular Swab Samples in Patients with Inflammatory Eye Disease

Omidian

Sheikhi-Shooshtari

2015

Iran J Virol

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Background and Aims: Cytomegalovirus (CMV) infection is very common in the population. Virus belongs to the family Herpesviridae, whose representatives are characterized by the ability to cause the human body's latent persistent infections. The goal of the study is to assess the CMVV infection frequency and PCR method in the choice of CMV in inflammatory eye disease, Comparing with CMV presence in Eye Infection and the control group. Materials and Methods: Primers were designed for conserved regions of the CMV genome. We have used PCR to rapid, accurate detection of EBV DNA in blood and from eye swabs as well as pp65 antigenemia. We have chosen to study patients with eye inflammation or infection symptom. Results: CMV DNA was detectable in three 21 out of 130 control samples of serum (16.5%). CMV infection was seen in 9 out of 20 (45%) patients' serum samples. Compared with the controls, the presence of EBV DNA was only significantly increased in samples of the patient group. 13 out of 20 (65%) patients in patients and 19 out of 130 (14.61%) of the control group had detectable CMV DNA in their ocular swab. Conclusion: We have presented evidence for the presence of CMV sequences in normal and eye inflammation samples with PCR. CMV serology was available for a large number of individuals. The prevalence of CMV in ocular disease samples varied dramatically that this wide range may be due to variations and inconsistency in the techniques used to detect the virus and its Components, as well as geography and genetic susceptibility.

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Seroprevalence of Cytomegalovirus Antibodies Among COVID-19 Patients

Ibrahim

2021

Biomed. Pharmacol. J.

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One of the biggest infectious diseases for humans in modern history is the COVID-19 pandemic. The disease mechanisms of human viral infections have been modified by virus-virus interaction. This study was carried out to detect the seroprevalence of CMV in COVID-19 patients. A total of 105 cases (58 females and 47 males) with an age range of 17-65 years (mean age 39.52±11.02 years) were included in this study. HCMV-IgG and IgM were determined in subjects' cases. Sixty-five out of 105 (62%) were positive for SARS-CoV-2, while 40 (38%) had negative SARS-CoV-2. Forty-seven (72.3%) and 11 (16.9%) cases out of 65 SARS-CoV-2 positive patients were positive for CMV-IgG and IgM antibodies, respectively. No significant differences were noted between females and males in terms of seroprevalence rates. A high rate of positive CMV-IgG was observed among 40-64 years COVID-19 patients. It is concluded that the seroprevalence of CMV antibodies amongst COVID-19 cases is high in relation to findings in cases without SARSCoV-2.

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Acquisition of cytomegalovirus infection: an update.

Cited by 3 publications

References 109 publications

Immunological Indicators in Aborted Women Infected with Human Cytomegalovirus in Karbala City, Iraq

Immunological Indicators in Aborted Women Infected with Human Cytomegalovirus in Karbala City, Iraq

Cytomegalovirus PCR Analysis of Serum and Ocular Swab Samples in Patients with Inflammatory Eye Disease

Seroprevalence of Cytomegalovirus Antibodies Among COVID-19 Patients

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