Acquisition and retention of enhanced active avoidance are unaffected by interference with serotonergic activity

Galindo, Lauro Bucio; Garín-Aguilar, María Eugenia; Medina, Andrea C.; Serafín, Norma; Quírarte, Gina L.; Prado-Alcalá, Roberto A.

doi:10.1016/j.bbr.2008.01.011

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…The training and testing procedures have been described in detail elsewhere [29]. Briefly, during each of the 20 training trials, the animal was introduced into the shock compartment of the two-compartment box, and the guillotine door dividing the compartments was opened.…”

Section: One-way Active Avoidance Trainingmentioning

confidence: 99%

Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

González-Salinas

Medina

Marín-Vignando

et al. 2015

Behavioural Brain Research

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Section: One-way Active Avoidance Trainingmentioning

confidence: 99%

Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

González-Salinas

Medina

Marín-Vignando

et al. 2015

Behavioural Brain Research

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“…Thus, generalized interference with cholinergic or serotonergic central activity produces amnesia of inhibitory avoidance (IA) trained with relatively low levels of foot-shock, but memory remains intact when higher levels of stimulation are used during training (e.g., Duran-Arevalo et al, 1990; Galindo et al, 2008). Similarly, long-term memory deficits of IA are produced by hindrance of synaptic activity of the striatum, amygdala, and substantia nigra; in contrast, under this circumstance memory is spared after enhanced IA training (Giordano and Prado-Alcalá, 1986; Pérez-Ruíz and Prado-Alcalá, 1989; Parent et al, 1992, 1995; Parent and McGaugh, 1994; Prado-Alcalá, 1995; Cobos-Zapiaín et al, 1996; Salado-Castillo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Extinction procedure induces pruning of dendritic spines in CA1 hippocampal field depending on strength of training in rats

Garín-Aguilar¹,

Dı́az-Cintra²,

Quírarte³

et al. 2012

Front. Behav. Neurosci.

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Numerous reports indicate that learning and memory of conditioned responses are accompanied by genesis of dendritic spines in the hippocampus, although there is a conspicuous lack of information regarding spine modifications after behavioral extinction. There is ample evidence that treatments that typically produce amnesia become innocuous when animals are submitted to a procedure of enhanced training. We now report that extinction of inhibitory avoidance (IA), trained with relatively low foot-shock intensities, induces pruning of dendritic spines along the length of the apical dendrites of hippocampal CA1 neurons. When animals are trained with a relatively high foot-shock there is a high resistance to extinction, and pruning in the proximal and medial segments of the apical dendrite are seen, while spine count in the distal dendrite remains normal. These results indicate that pruning is involved in behavioral extinction, while maintenance of spines is a probable mechanism that mediates the protecting effect against amnesic treatments produced by enhanced training.

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“…Our data demonstrates that not only the intensity but also the frequency of the applied current plays a key role in the performance in a step-down inhibitory avoidance and learning. This data of frequency is one of missing information in other studies using IAT [ 19 , 41 , 55 , 56 ]. We observed learning with 0.35mA and 0.5mA at 62 and 125Hz but not at 20Hz ( Fig.…”

Section: Discussionmentioning

confidence: 99%

A New Device for Step-Down Inhibitory Avoidance Task—Effects of Low and High Frequency in a Novel Device for Passive Inhibitory Avoidance Task That Avoids Bioimpedance Variations

et al. 2015

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BackgroundStep-down inhibitory avoidance task has been widely used to evaluate aversive memory, but crucial parameters inherent to traditional devices that may influence the behavior analysis (as stimulus frequency, animal’s bioimpedance) are frequently neglected.New MethodWe developed a new device for step-down inhibitory avoidance task by modifying the shape and distribution of the stainless steel bars in the box floor where the stimuli are applied. The bars are 2mm wide, with rectangular shape, arranged in pairs at intervals of 1cm from the next pairs. Each pair makes an electrical dipole where the polarity inverts after each pulse. This device also presents a component that acquires and records the exact current received by the animal foot and precisely controls the frequency of stimulus applied during the entire experiment.ResultDifferent from conventional devices, this new apparatus increases the contact surface with bars and animal´s paws, allowing the electric current pass through the animal´s paws only, drastically reducing the influence of animal’s bioimpedance. The analysis of recorded data showed that the current received by the animal was practically the same as applied, independent of the animal´s body composition. Importantly, the aversive memory was observed at specific stimuli intensity and frequency (0.35 or 0.5 mA at 62 and 125Hz but not at 0.20 mA or 20 Hz). Moreover, with this device it was possible to observe the well-known step-down inhibitory avoidance task memory impairment induced by guanosine.ConclusionThis new device offers a substantial improvement for behavioral analysis in step-down inhibitory avoidance task and allows us to precisely compare data from different animals with distinct body composition.

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Acquisition and retention of enhanced active avoidance are unaffected by interference with serotonergic activity

Cited by 11 publications

References 43 publications

Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

Extinction procedure induces pruning of dendritic spines in CA1 hippocampal field depending on strength of training in rats

A New Device for Step-Down Inhibitory Avoidance Task—Effects of Low and High Frequency in a Novel Device for Passive Inhibitory Avoidance Task That Avoids Bioimpedance Variations

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