Acquisition and Clearance of Perianal Human Papillomavirus Infection in Relation to HIV‐positivity in Men Who Have Sex with Men in the Netherlands

Snoek, Eric M van der; Niesters, Hubert G. M.; Doornum, G. J. J. Van; Mulder, Paul; Osterhaus, Albert D. M. E.; Meijden, W I van der

doi:10.1080/00015550510032850

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…If approved for use in males, HPV vaccine may offer great benefits to gay and bisexual men due to their high rates of HPV infection 7-9 and HPV-associated anal cancer. 12 We currently know little about the acceptability of the vaccine among gay and bisexual men.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are in line with previous reports of low HPV knowledge among gay and bisexual men. 27,28 Given the high levels of anal HPV infection among gay and bisexual men, 7-9 these results are especially concerning. Future efforts need to ensure that gay and bisexual men are aware of not only HPV and how it is transmitted, but also diseases associated with HPV infection and how infected men can reduce their risk of developing HPV-related cancers.…”

Section: Discussionmentioning

confidence: 99%

“…The estimated prevalence of anal HPV infection among gay and bisexual men is about 60% among human immunodeficiency virus (HIV)-negative individuals and even higher among HIV-positive individuals, perhaps over 90%. 7-9 Men who have sex with men (MSM) are also at greater risk for anal cancer compared with the general population, 10-12 with incidence rates increasing over the last few decades. 13 …”

mentioning

confidence: 99%

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Acceptability of HPV Vaccine Among a National Sample of Gay and Bisexual Men

Reiter¹,

Brewer²,

McRee³

et al. 2010

Sexually Transmitted Diseases

104

107

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Objective Due to higher rates of human papillomavirus (HPV) infection and anal cancer among gay and bisexual men, we aimed to characterize their willingness to get HPV vaccine and identify correlates of vaccine acceptability. Methods We surveyed a national sample of men aged 18 to 59 who self-identified as either gay (n = 236) or bisexual (n = 70) during January 2009. We analyzed data using multivariate logistic regression. Results Most men had heard of HPV vaccine (73%, 224/306) and were willing to get it (74%, 225/306). HPV vaccine acceptability was higher among men who believed their doctor would recommend getting the vaccine (OR = 12.87, 95% CI: 4.63–35.79) and those who were unsure (OR = 3.15, 95% CI: 1.47–6.76), as compared to men who believed their doctor would not recommend it. Acceptability was also higher among men who reported 5 or more lifetime sexual partners (OR = 3.39, 95% CI: 1.34–8.55), perceived greater severity of HPV-related disease (OR = 1.92, 95% CI: 1.18–3.14), perceived higher levels of HPV vaccine effectiveness (OR = 1.97, 95% CI: 1.27–3.06), or reported higher levels of anticipated regret if they did not get vaccinated and later developed an HPV infection (OR = 2.39, 95% CI: 1.57–3.61). Conclusions HPV vaccine acceptability was high among gay and bisexual men. These findings identify potentially important beliefs and attitudes for future communication efforts about HPV and HPV vaccine among gay and bisexual men.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Acceptability of HPV Vaccine Among a National Sample of Gay and Bisexual Men

Reiter¹,

Brewer²,

McRee³

et al. 2010

Sexually Transmitted Diseases

104

107

View full text Add to dashboard Cite

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“…Three of the 11 studies included in this review had a cohort study design and the remaining 8 were cross-sectional studies. Furthermore, our selected articles provided both cross-sectional [4,8,10,11,13,15,16,17] and longitudinal data [3,9,18] comparing HPV and HIV. Four of the 11 studies were conducted in the US and the other 7 in Buenos Aires (n = 1), Lima Peru (n = 1), Vancouver, Canada (n = 1), China (n = 2), Germany (n = 1) and Netherlands (n = 1) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

The Role of Human Papillomavirus in Human Immunodeficiency Virus Acquisition in Men who Have Sex with Men: A Review of the Literature

Brown

Davtyan

Galea³

et al. 2012

Viruses

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Human Papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) worldwide. Incidence rates of HPV infection among human immunodeficiency virus (HIV)-infected individuals are well documented and are several-fold higher than among HIV-uninfected individuals. Few studies have demonstrated an increased risk for acquiring HIV infection in those with HPV infection, and this risk seems to be higher when HPV strains are of high-risk oncogenic potential. The estimated prevalence of high-risk oncogenic HPV infection is highest in men who have sex with men (MSM), a particularly vulnerable group with high prevalence rates of HIV infection and other STIs. In this paper, we provide a comprehensive review of the available literature on the role of HPV infection in HIV acquisition. Our review includes data from cross-sectional and longitudinal studies.

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“…Durch die Interaktion von E6 und E7 mit p53 und Rb kommt es zur Dysregulierung des Zellzyklus, Instabilität des Genoms, sowie Inhibition von Apoptose und Telomerase und damit zur Immortalisierung der Zelle [31]. Zahlreiche epidemiologische Studien konnten zeigen, dass neben der persistierenden HPV-Infektion die Infektion mit multiplen HPV-Typen, die HIV-Infektion, die iatrogene Immunosuppression und Rauchen in der Pathogenese von AIN und Analkarzinom eine wichtige Rolle spielen [11,12,15,16,20,[32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Karzinogeneseunclassified