Acquired loss of hair pigment associated with a flexural dermatosis

Abbott, Rachel; Robson, Alistair; O'Donoghue, N. B.

doi:10.1111/j.1365-2230.2008.02917.x

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…However, these findings are not pathognomonic of kwashiorkor and may be found in other conditions that have nutritional deficit as causal factor. 6,7 The diagnosis of energy-protein malnutrition with predominant characteristics of kwashiorkor was confirmed in our patient, based on ectoscopic alterations found on physical examination corroborated by laboratory tests. It was related to a secondary form of energy-protein malnutrition due to anatomic alterations imposed on abdominal visceral organs by the surgical procedure performed, since structures that are fundamental for nutrient digestion and absorp- …”

Section: Discussionsupporting

confidence: 73%

Alterações cutâneas no Kwashiorkor: relato de caso de um homem adulto após cirurgia abdominal

Mann

Presotto

Queen

et al. 2011

An. Bras. Dermatol.

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Abstract:Kwashiorkor is a type of protein-energy malnutrition where diet protein deficit is found, in spite of appropriate caloric intake. Cutaneous manifestations include xerosis, with abnormally dry skin that has a flaking enamel paint aspect, a typical red to gray-white hair color, the "flag sign" and more evident edema in lower limbs and face, giving it a full moon appearance. This article reports a case of a male adult patient who had undergone Whipple surgery for treatment of chronic pancreatitis associated with pseudotumor of the pancreatic head that progressed to cutaneous manifestations of kwashiorkor after pulmonary tuberculosis. Keywords: Pancreatitis, chronic; Protein-energy malnutrition; Tuberculosis, pulmonary Resumo: Kwashiorkor é um tipo de desnutrição proteico-energética em que há deficiência dietética de proteí-na, embora a ingestão de calorias se mantenha adequada. As manifestações cutâneas incluem pele xerótica, com aspecto de esmalte descascado, típica coloração avermelhada a branco-acinzentada dos cabelos, o sinal da bandeira e edema mais evidente, nos membros inferiores e na face, dando aspecto de lua cheia. O presente artigo relata o caso de um paciente adulto, do sexo masculino, previamente submetido à duodenopancreatectomia para tratamento de pancreatite crônica associada ao pseudotumor em cabeça de pâncreas que evoluiu com alterações cutâneas de kwashiorkor após tuberculose pulmonar.

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Section: Discussionsupporting

confidence: 73%

Alterações cutâneas no Kwashiorkor: relato de caso de um homem adulto após cirurgia abdominal

Mann

Presotto

Queen

et al. 2011

An. Bras. Dermatol.

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“…Malnutrition cases are uncommon in developed nations unless associated with problems in dietary intakes 75 . Such a case was recently reported where a young woman in the UK showed a change of hair colour from dark brown to pale yellow during a long period of low dietary intake 76 …”

Section: Pathological Aspects Of the Diversity Of Human Pigmentationmentioning

confidence: 99%

“…75 Such a case was recently reported where a young woman in the UK showed a change of hair colour from dark brown to pale yellow during a long period of low dietary intake. 76 Deficiencies in trace metal ions may also lead to hypopigmentation. Tyrosinase requires copper ion at its active centre.…”

Section: Malnutrition and Trace Metal Deficiencymentioning

confidence: 99%

Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin

Ito

Wakamatsu

2011

Acad Dermatol Venereol

104

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Hair colour is one of the most conspicuous phenotypes in humans, ranging from black, brown, blond to red. This diversity arises mostly from the quantity and ratio of the black-dark brown eumelanin and the reddish-brown pheomelanin. To study the chemical basis underlying the diversity of hair colour, we have developed several chemical methods to quantify those two pigments. Alkaline H(2) O(2) oxidation affords pyrrole-2,3,5-tricarboxylic acid (PTCA) as a eumelanin marker and thiazole-2,4,5-tricarboxylic acid (TTCA) as a pheomelanin marker. Pheomelanin can also be analysed as 4-amino-3-hydroxyphenylalanine (4-AHP) after hydroiodic acid hydrolysis. Using those methods, we evaluated the contents of eumelanin and pheomelanin (the 'chemical' phenotype) in human hairs of black, dark brown, brown, light brown, blond and red colour (the 'visual' phenotype). Eumelanin contents decrease in that order, with a trace but constant level of pheomelanin, except for red hair which contains about equal levels of pheomelanin and eumelanin. Thus, the chemical phenotype correlates well with the visual phenotype. The genotype of melanocortin-1 receptor (MC1R), a gene regulating the red hair phenotype, is predictive of hair melanin expressed as the log value of eumelanin to pheomelanin ratio, with a dosage effect evident. Hair melanin contents were also analysed in patients with various hypopigmentary disorders including Hermansky-Pudlak syndrome, Menkes disease, proopiomelanocortin deficiency, cystinosis, malnutrition and trace metal deficiency. The chemical phenotype helped evaluate the precise effects of each disease on pigmentation. In studies of human hair, the chemical phenotype will find more and more application as an objective measure of pigmentation.

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“…During substitution with zinc, the ulcers on the lower extremities healed. Later, Abbott et al 12 described a woman aged 28 years with eating disorder and a 6-month history of rash on the lower extremities. At examination, she had ascites and peripheral oedemas.…”

Section: Discussionmentioning

confidence: 99%

Kwashiorkor: an unexpected complication to anorexia nervosa

Palm¹,

Frølich²,

Snogdal

et al. 2016

BMJ Case Reports

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We present the case of a woman aged 48 years, diagnosed with anorexia nervosa (AN) at the age of 12. She was admitted to a highly specialised eating disorder facility with distended abdomen, muscular atrophy, ulcerative dermatitis, electrolyte derangements and low serum albumin. Her weight was 53.1 kg, corresponding to a body mass index (BMI) of 17.9 kg/m After initial stabilisation, a therapeutic ascites puncture relieved the patient from 6500 mL of ascites. After 6 weeks of nutritional and diuretic treatment, the patient was discharged with a weight of 46.8 kg (BMI 15.7 kg/m), without ascites and with healed ulcerations. The condition was consistent with kwashiorkor, a complication to malnutrition rarely seen in AN.

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Acquired loss of hair pigment associated with a flexural dermatosis

Cited by 5 publications

References 6 publications

Alterações cutâneas no Kwashiorkor: relato de caso de um homem adulto após cirurgia abdominal

Alterações cutâneas no Kwashiorkor: relato de caso de um homem adulto após cirurgia abdominal

Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin

Kwashiorkor: an unexpected complication to anorexia nervosa

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