Acquired immunodeficiency in murine lymphoproliferative disease: Considerations on pathogenesis

Thacore, Harshad R.; Cunningham, Roger K.; Zhou, Paul; Nakeeb, Shaheen; Terzian, R.; Zaleski, Marek

doi:10.1016/s0171-2985(11)80269-x

Cited by 8 publications

(10 citation statements)

References 38 publications

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“…Transfusion and Murine Lymphoproliferative Disease where [7,8]. The results presented above can be assessed from two points of view.…”

Section: Discussionmentioning

confidence: 99%

“…Disease in the original donors was induced by a single i.p. injection of 1 x 105 FFU [7,8], Donor's biood was collected from the tail into 3.7% sodium ci trate at a citrate: blood ratio of 1:10. For whole blood.…”

Section: Methodsmentioning

confidence: 99%

“…and T cell receptor V^. The inclusion of marker in the anal ysis was justified by the earlier observations that LP-BM5-induced lymphoproliferative disease is accompanied, due to a virus-associ ated superantigen [11], by a dramatic expansion of the cells carrying this marker (8,11]: the V,* marker served as a control.…”

Section: Methodsmentioning

confidence: 99%

“…From a variety of possible stimulators, IL-2 and the mixtures of phorbol ester and IL-2 or an ionophorc were selected because of the earlier findings that spleen cells from LP-BM5-infccted mice retain most of their ability to respond to IL-2 but lose capability of responding to the two mixtures employed [7,8], A single-cell suspension was originally prepared in ice-cold ACK that, after two washes in HBSS, was replaced by culture medium-RPMI 1640 fortified with 5% fetal bovine scrum. 2 mM glutamine, penicillin and streptomycin (all reagents from Gibco, Grand Island, N. Y., US A).…”

Section: Methodsmentioning

confidence: 99%

“…With this in mind, we carried out a series of experiments to es tablish a workable model [8]. In the process, we realized that one of the technical obstacles in performing routine experiments is posed by the need for continuous mainte nance of virus-producing cultures [9] and variability in vi rus yield from batch to batch of such cultures.…”

mentioning

confidence: 99%

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Blood Transfusion as a Means for Transmission of Retrovirus-Induced Lymphoproliferative Disease in Mice

Cunningham

Thacore

Zhou

et al. 1994

Int Arch Allergy Immunol

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Lymphoproliferative disease was elicited in C57BL/6KH and (BALB/c × C57BL/6)F1 hybrids by a single intraperitoneal injection of 10⁵ FFU of LP-BM5 virus preparation. The disease could reproducibly be transferred by a single intravenous transfusion of 0.2 ml of whole blood as well as 0.1 ml of blood cells, plasma or serum from the infected animals. F1 hybrids displayed a delayed development of the disease when an acellular virus preparation was administered, but they were fully susceptible to the disease when syngeneic blood from infected F1 donors was transfused. Blood from donors in the prodromal stage was as effective in transmission of the disease as blood from donors with fully developed disease. This indicated that in murine lymphoproliferative disease viremia develops very early in the course of the disease. It seems that using the blood transfusion one could develop a reliable semiquantitative assay for the infectiveness of the animals suffering from LP-MB5-induced lymphoproliferative disease.

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“…Transfusion and Murine Lymphoproliferative Disease where [7,8]. The results presented above can be assessed from two points of view.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Blood Transfusion as a Means for Transmission of Retrovirus-Induced Lymphoproliferative Disease in Mice

Cunningham

Thacore

Zhou

et al. 1994

Int Arch Allergy Immunol

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show abstract

Antiviral Efficacy and Toxicity of Ribavirin and Foscarnet Each Given Alone or in Combination in the Murine AIDS Model

Omar

Harvie

Gourde

et al. 1997

Toxicology and Applied Pharmacology

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Murine AIDS: A model for the human disease or a distinct entity?

et al. 1994

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The LP-BM5 mixture of murine retroviruses elicits a disease in mice referred to as murine immunodeficiency syndrome (MAIDS) that is considered by some to be an animal homologue of human AIDS. In this article, we present and discuss some recent findings on the pathogenesis of the murine disease and their implications for the proposed homology between murine and human syndromes. The murine disease seems to display as many similarities to as it does differences from human AIDS. Among the latter are: definitive and exclusive viral etiology, a strong genetic effect on susceptibility to infection, expansion of the CD4+ cell population in spleen and peripheral blood, consistent transmissibility by a single transfusion of the minute amounts of blood or plasma from infected donors, and striking similarity between virus-induced alteration of the in vitro spleen cell proliferation and those caused by treatment with a protein kinase inhibitor K252a. With this in mind, the use of the noncommittal term retrovirus-induced murine lymphoproliferative disease instead of MAIDS appears to be more appropriate at this time.

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Acquired immunodeficiency in murine lymphoproliferative disease: Considerations on pathogenesis

Cited by 8 publications

References 38 publications

Blood Transfusion as a Means for Transmission of Retrovirus-Induced Lymphoproliferative Disease in Mice

Blood Transfusion as a Means for Transmission of Retrovirus-Induced Lymphoproliferative Disease in Mice

Antiviral Efficacy and Toxicity of Ribavirin and Foscarnet Each Given Alone or in Combination in the Murine AIDS Model

Murine AIDS: A model for the human disease or a distinct entity?

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