Acquired ichthyosis in a patient with systemic lupus erythematosus

Font, J.

doi:10.1001/archderm.126.6.829b

Cited by 7 publications

(4 citation statements)

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“…1,3 To our knowledge, our case is the first to describe AI associated with the overlap syndrome of SSc and SLE, although an association with SLE has been noted in rare cases. 2,3,5,6 Connective tissue disease is usually classified into distinct entities, although some patients may show features that overlap between classifications. Overlap syndromes include polymyositis with SSc or SLE, SSc with erosive rheumatoid arthritis, SSc with vasculitis, SSc with multiple sclerosis, SSc with myositis and SSc with SLE.…”

Section: Discussionmentioning

confidence: 99%

Acquired ichthyosis associated with an overlap syndrome of systemic sclerosis and systemic lupus erythematosus

Lee

Ahn

Choi

et al. 2006

The Journal of Dermatology

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Acquired ichthyosis is a condition accompanying many systemic illnesses such as lymphoma, sarcoidosis, dermatomyositis and systemic lupus erythematosus (SLE). Overlap syndromes are defined as clinical entities which satisfy each of the diagnostic criteria of two different connective tissue diseases concurrently or consecutively. The coexistence of SLE with systemic sclerosis has been very rarely reported. We describe a 33-year-old woman with an overlap syndrome consisting of systemic sclerosis and SLE who developed ichthyosis on her extremities.

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Section: Discussionmentioning

confidence: 99%

Acquired ichthyosis associated with an overlap syndrome of systemic sclerosis and systemic lupus erythematosus

Lee

Ahn

Choi

et al. 2006

The Journal of Dermatology

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“…The skin changes cleared with therapy, and the clinical evolution was similar to the patient's underlying disease. 4,5,9 Scaling is most extensive on the extensor surfaces of the extremities, with a sharp demarcation between normal exor surfaces and the surrounding affected areas. In general, the lower extremities are more affected than the upper extremities.…”

Section: Discussionmentioning

confidence: 99%

“…It is associated with many systemic diseases, such as cancer, leprosy, sarcoidosis, thyroid disease and bone marrow transplant. 1 Autoimmune disorders, such as dermatomyositis 2,3 and systemic lupus erythematosus (SLE), 4,5 are also linked.…”

Section: Introductionmentioning

confidence: 99%

Acquired ichthyosis associated with systemic lupus erythematosus

Tlacuilo-Parra

Guevara‐Gutiérrez

Salazar-Páramo

2004

Lupus

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Acquired ichthyosis is an uncommon disease, it is characterized by symmetric scaling of the skin, which ranges from minor roughness and dryness to the desquamation of large plaques. It has been associated with various systemic diseases, although malignant conditions, especially Hodgkin's lymphoma are the most commonly cited. Drugs, HIV infection and autoimmune diseases such as dermatomyositis and mixed connective tissue disease have also been associated, and it has only rarely been found among patients with systemic lupus erythematosus (SLE). Herein, we report a patient with active SLE who developed a generalized acquired ichthyosis corroborated with skin biopsy, which completely disappeared after treatment. The association of autoimmune conditions with acquired ichthyosis could indicate that an abnormal host immune response, probably against components of the granular cell layer in particular the keratohyalin granules, may have a role in the pathogenesis. Thus, this finding may be a relevant cutaneous marker for an autoimmune origin.

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“…[4] There is great variation in incidence, clinical heterogenecity, and severity of disease between different ethnic and racial groups due to environmental, cultural, and genetic variability. [5] Diversity was also noted in the type of skin involvement ranging from classical butterfly rash, discoid lupus to bullae, alopecia, vasculitic rashes, etc. [6]…”

Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations of systemic lupus erythematosus in a tertiary referral center

Kole

Ghosh

2009

Indian J Dermatol

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Background:Systemic lupus erythematosus (SLE) is an autoimmune disease with multiorgan involvement. The skin is the second most commonly affected organ. SLE with skin lesions can produce considerable morbidity resulting from painful skin lesions, alopecia, disfigurement, etc. Skin lesions in patients with lupus may be specific (LE specific) or may be non specific (LE non specific). Acute cutaneous LE (Lupus specific) has a strong association with systemic disease and non-specific skin lesions always indicate disease activity for which patients present to rheumatologists and internists. Therefore, a thorough understanding of the cutaneous manifestations of SLE is essential for most efficient management.Aims:The aims of this study were to evaluate the patterns and prevalence of skin lesions in patients with SLE and to assess the relationship between skin lesions and other systemic involvement.Materials and Methods:At the Department of Rheumatology and Clinical Immunology, IPGME&R in Kolkata, 150 patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatology Association (updated 1982) were examined and followed-up for cutaneous manifestations between January 2002 and January 2007.Results:Skin lesions were important clinical features. About 45 patients (30%) presented with skin lesions although all patients had skin lesions during the follow-up period. Skin changes noted were as follows: Lupus specific lesions: malar rash in 120 patients (80%), photosensitive dermatitis in 75 patients (50%), generalized maculopapular rash in 40 patients (26.67%), discoid rash in 30 patients (20%), subacute cutaneous lupus erythematosus (SCLE) in 5 patients (3.34%), lupus profundus in 5 patients (3.34%). The lupus non-specific lesions were non-scarring alopecia in 130 patients (86.67%), oral ulcers in 85 patients (56.67%), vasculitic lesions in 50 patients (33.34%), bullous lesions in 15 patients (10%), Raynaud's phenomenon in 10 patients (6.67%), pyoderma gangrenosum in 2 patients (1.34%), erythema multiforme in 10 patients (6.67%), and nail fold infarcts in 2 patients (1.34%); however, mucosal discoid lupus, lichenoid discoid lupus, livedo reticularis, sclerodactyly, etc. were not detected. Patients having lupus-specific skin lesions e.g., malar rash were associated with systemic involvement, whereas those having lupus non-specific skin lesions were associated with disease flare.Conclusions:Skin lesions in patients with SLE are important disease manifestations and proper understanding is essential for diagnosis and efficient management.

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Acquired ichthyosis in a patient with systemic lupus erythematosus

Cited by 7 publications

References 0 publications

Acquired ichthyosis associated with an overlap syndrome of systemic sclerosis and systemic lupus erythematosus

Acquired ichthyosis associated with an overlap syndrome of systemic sclerosis and systemic lupus erythematosus

Acquired ichthyosis associated with systemic lupus erythematosus

Cutaneous manifestations of systemic lupus erythematosus in a tertiary referral center

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