Acquired ichthyosis associated with an overlap syndrome of systemic sclerosis and systemic lupus erythematosus

Abstract

Acquired ichthyosis is a condition accompanying many systemic illnesses such as lymphoma, sarcoidosis, dermatomyositis and systemic lupus erythematosus (SLE). Overlap syndromes are defined as clinical entities which satisfy each of the diagnostic criteria of two different connective tissue diseases concurrently or consecutively. The coexistence of SLE with systemic sclerosis has been very rarely reported. We describe a 33-year-old woman with an overlap syndrome consisting of systemic sclerosis and SLE who developed ichthyosis on her extremities.

Ichthyotic‐Appearing Skin Changes Associated with Childhood Morphea, Systemic Sclerosis, and Systemic Lupus Erythematosus/Scleroderma Overlap

“…This finding suggests that in certain pediatric patients, ichthyotic‐appearing skin may predict future involvement of morphea. This is not unexpected given the previously reported associations of ichthyosis and autoimmune diseases (1–8). However, ichthyotic‐appearing skin predicting clinical course is a novel concept that warrants further investigation.…”

“…The first report of ichthyotic‐appearing skin seen in association with autoimmunity was in 1980, when Duvic and Jegasothy reported an adult female patient with systemic lupus erythematosus (1,2). Since then, numerous authors have noted ichthyotic‐appearing skin occurring in association with other autoimmune disorders, such as thyroiditis (3), dermatomyositis (4,5), diabetes mellitus (6,7), and systemic sclerosis and systemic lupus erythematosus overlap (8), prompting some to suggest that acquired ichthyosis should be a marker for autoimmunity (9). To date, the only autoimmune condition in children reported to be associated with acquired ichthyotic‐appearing skin is insulin‐dependent diabetes mellitus (7).…”

Acquired ichthyosis and secondary hyperparathyroidism with systemic lupus erythematosus

“…Ichthyosis, both hereditary and acquired, involves symmetric scaling of the skin, most prominently on the extensor surfaces of the extremities. 1 Acquired Figure 3 Cardiothoracic ratio increased significantly, large pericardial effusion. ichthyosis may be associated with malignancy, medication, and, rarely, autoimmune disease, and many systemic illnesses such as lymphoma, sarcoidosis, dermatomyositis, and SLE.…”

Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo

“…Most often, acquired ichthyosis is seen as a paraneoplastic phenomenon and occasionally associated with autoimmune diseases such as lupus [ 6 , 7 ]. The combination of a sclerodermoid-ichthyosis overlap has been reported in association with both systemic lupus erythematosus and scleroderma, but not PCT [ 8 , 9 ].…”