Acquired hemolytic anemia and transient erythroid hypoplasia of bone marrow

Pure Red Cell Anaemia and Thymoma

“…The autoantibodies there fore have to be directed against either the erythroblasts, the nuclei of the erythroblast or some factor governing the production of erythro cytes, for instance erythropoietin. It is well known that immunologic or allergic mechanisms are able to produce a selective erythroblastic aplasia in the bone marrow, for example in typical autoimmune haemolytic anaemias (15)(16)(17)(18)(19)(20)(21), following iso-immunization by blood group A (22) or rhesus-isoimmunization (23), and in the course of diseases associated with autoimmune phenomenons, for instance leukaemia (24) or lymphosarcoma (6). Schooi.ey and G arcia (25) have been able to reduce the erythropoiesis in mice by means of an antibody against erythropoietin suggesting that an autoantibody against erythropoietin might be able to produce pure red cell anaemia in man.…”

Aplastic Crises in Haemolytic Anaemias: The Role of a Parvovirus‐like Agent

“…19 59 ), paroxysmal nocturnal haemoglobinuria (Crosby. 19 5 3 ) and acquired immune haemolytic anaemia (Meyer & Bertcher, 1960). From reading these reports it appears unlikely that PVLA would have played a part in causing the aplasia.…”