Aplastic Crises in Haemolytic Anaemias: The Role of a Parvovirus‐like Agent

High Serum Iron in Human Parvovirus-Induced Aplastic Crisis in Iron Deficiency Anemia

“…Firstly, because red blood cell aplasia linked to HPV infection had been recognized mostly in patients with chronic hemolytic anemia with short ened red cell life span, it was considered that the very active marrow found in these circumstances might be necessary for the replication of HPV [4]. The report showed that erythroid progenitors in a patient with IDA who had normal red blood cell life span could be a target of HPV infection.…”

Viral infection of vascular endothelial cells alters production of colony-stimulating activity.

“…fluenza virus, or parvovirus (10,11,19,36). A period of granulocytopenia frequently develops after infection with EBV or CMV (15)(16)(17).…”

“…For example, viral infections are frequently associated with the development ofgranulocytosis and/or granulocytopenia (10)(11)(12)(13), but the mechanisms by which these occur have received little study. Lymphocytes with the T helper phenotype, which are the most prevalent subset of T cells in healthy normal individuals, have been shown to be an important source of CSA (3,14).…”

Human Parvovirus B19 Erythrovirus

“…Acute parvovirus B19 infection produces erythema infectiosum in normal individuals but in immunocompromised patients unable to mount a neutralizing antibody response due to persistent bone marrow insufficiency the infection may cause pure red cell aplasia (22,292), chronic anaemia, transient aplastic crisis in patients with sickle cell disease (294) and haemolysis (79). Predisposing conditions include Nezelof 's syndrome (197), acute lymphoblastic leukaemia (187,195), large granular lymphocyte leukaemia (190) acute and chronic myeloid leukaemia leukaemia (119).…”