Acquired Cytomegalovirus Infection in Preterm Infants

The functions of herpesvirus-encoded microRNAs

“…HCMV infects a large percentage of the population and, although generally benign, this virus is considered a signiWcant pathogen in immunosuppressed patients, either undergoing immunosuppressive therapy following solid organ or bone marrow transplantation, or with AIDS [17][18][19][20][21][22][23][24]. In addition, HCMV is one of the leading viral causes of birth defects [25].…”

Cytomegalovirus in Breast Milk: Reassessment of Pasteurization and Freeze-Thawing

“…Viral shedding in breast milk is seen as early as 2-3 weeks after delivery, peaks in activity by 3-6 weeks, and usually ends in most individuals by 8 -10 weeks. CMV DNA analysis (18) was more sensitive than viral culture in detecting CMV in breast milk from CMV-positive donors (1,2,9). Kinetic studies conducted on virus recovered from milk whey after concentration by high-speed centrifugation correlated with viral DNA load.…”

Transmission of human cytomegalovirus via breastmilk and potential risks to very preterm infants

“…Sepsis-like symptoms (SLS) have been introduced as a term to describe symptomatic postnatal HCMV disease in VLBW preterm infants, comprising apnea and bradycardia, hepatosplenomegaly, grey pallor and distending bowels 24,25 . Following maternal HCMV reactivation and shedding into BM (in 96% of seropositive mothers), the incidence of HCMV transmission to the infant feeding raw, untreated breastmilk was 38% at the age of 3 months corrected age, 18% of the infants had one or more SLS 5 .…”