Acquired Cystic Disease of the Kidney: A Management Dilemma

Renal Cell Carcinoma in Cases of Adult Polycystic Kidney Disease: Changing Diagnostic and Therapeutic Implications

“…Some have advocated prophylactic bilateral nephrectomies [3,9] on the basis of difficulty in preoperative diagnosis and that it may be a premalignant condition [11]. Others have preferred a unilateral nephrectomy because of the obvious disadvantages of bilateral nephrectomies [12]. Hence only the diseased kidney harboring malignancy should be nephrectomized, and utmost attention and follow-up are warranted for the remaining renal unit with all available appropriate investigative modalities.…”

“…Urol Int 2000;64: [9][10][11][12] Hemal/Khaitan/Singh/Kumar 3). On long-term follow-up of 2 years none of the patients developed contralateral tumors or distant metastases, except for 1 who had a recurrence in the renal fossa.…”

Acquired Renal Cystic Disease and Adenocarcinoma following Renal Transplantation – A Current Urologic Perspective

“…The prevalence of ACKD is 190% in patients on longterm hemodialysis [4]. A comprehensive review of ACKD in ESRD found an overall radiologic imaging prevalence rate of 35% and an autopsy/nephrectomy prevalence rate of 41% [12].…”

“…The reported incidence of renal tumors (adenomas and carcinomas) in patients with ACKD is variable, depending on the definition of ACKD, method of detection (ul- [7,12,22]. Most studies have demonstrated that renal cancer occurs in 6-20% of patients with ACKD [4,17].…”

Renal Cell Carcinoma in Dialysis Patients with End Stage Renal Disease: Focus on Surgery and Pathology

“…ACDK has been defined as macroscopic cystic structures compromising at least 25% of the renal parenchyma or greater than 3 cysts per kidney in a patient in renal failure who was not known to have cysts prior to the onset of renal failure and in whom there is no family history or other evidence of an inherited cystic disease 1 . Of patients on dialysis for less than 3 years 10% to have ACDK, 40% to 60% on dialysis for 3 years have ACDK and more than 90% have ACDK after 5 years on dialysis 24 . The current study also demonstrated that duration of dialysis was closely related with development of ACDK.…”