Acquired Renal Cystic Disease and Adenocarcinoma following Renal Transplantation – A Current Urologic Perspective

Sant, Grannum R.; Ucci, Angelo A.

doi:10.1159/000030222

Cited by 12 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11,13,14,28 The role of the calcium oxalate crystals in the development of renal cell tumors in the context of acquired cystic disease of kidney is uncertain. 11,14,29 Immunohistochemical studies on acquired cystic disease-associated renal tumors are few, and mostly 33 described in abstract form FISH analyses with centromeric probes for chromosomes 1, 3, 7, and 17 on 10 tumors arising in end-stage renal disease, among which two acquired cystic kidney diseaseassociated tumors were included. They found that both tumors were disomic for chromosomes 1 and 3, whereas one had loss of chromosome 7 and the other showed loss of chromosome 17.…”

Section: Discussionmentioning

confidence: 99%

Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study

et al. 2006

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study

et al. 2006

View full text Add to dashboard Cite

“…Even after transplantation periodic surveillance of the kidneys, both native and transplant, is warranted, although firm guidelines backed by hard data are not yet available [33,34].…”

Section: Transplantationmentioning

confidence: 99%

Acquired cystic kidney disease

Choyke

2000

European Radiology

View full text Add to dashboard Cite

Acquired cystic kidney disease (ACKD), also known as acquired renal cystic disease (ARCD,) occurs in patients who are on dialysis for end-stage renal disease. It is generally accepted that ACKD develops as a consequence of sustained uremia and can first manifest even before dialysis is initiated while the patient is still in chronic renal failure. The role of immune suppression, particularly in transplant recipients, in the development of ACKD, is still under investigation. The prevalence of ACKD is directly related to the duration of dialysis and the risk of cancer is directly related to the presence of cysts. Herein we review the current understanding of the pathophysiology and imaging implications of ACKD.

show abstract

“…Von diesem hereditären Krankheitsbild ist die erworbene zystische Nierendysplasie (ACKD = aquired cystic kidney disease) zu unterscheiden, welche vornehmlich nach langjähriger Dialysetherapie beobachtet wird. In mehreren Untersuchungen (Patientenkollektive nach Nierentransplantation) wurde ebenfalls ein gehäuftes Auftreten von Nierenzellkarzinomen (6 -20 %) festgestellt [2,10,11,16,19], jedoch ist bislang unklar, ob die Tumorentstehung auf die Dialysebehandlung, die adjuvante Therapie zur Transplantation oder die Grunderkrankung zurückgeführt werden muß. Demgegenüber finden sich keine Berichte über eine Häufung von Urothelkarzinomen bei Patienten mit polyzystischen Nieren.…”

Section: Diskussionunclassified

Beidseitiges Urothelkarzinom in Kombination mit beidseitigem Nierenzellkarzinom

Anding¹,

Tan²,

Walz³

1999

Akt Urol

View full text Add to dashboard Cite

ZusammenfassungEinleitung: Wir berichten über den ersten bekannten Fall eines beidseitigen Urothelkarzinoms in Kombination mit einem beidseitgen Nierenzellkarzinom bei einer Patientin mit (dialysepflichtiger) polyzystischer Nierendysplasie. Kasuistik: Aufgrund eines Nierenbeckentumors erfolgte zunächst die einseitige Nephrektomie, wonach im pathologischen Präparat ein okkultes Nierenzellkarzinom entdeckt wurde. 5 Monate später erfolgte die Entfernung der Gegenniere bei erneutem Nierenbeckentumor, ebenfalls fand sich im Präparat zusätzlich ein Nierenzellkarzinom. Schlußfolgerung: Das koinzidente Auftreten von Transitionalzellkarzinomen des Nierenbeckens und Nierenzellkarzinomen ist sehr selten, häufiger sind bilaterale Nierenzellkarzinome anzutreffen. In diesen Fällen kommen in zunehmender Häufigkeit organsparende Operationstechniken zur Anwendung. Bereits beobachtet wurde ein gehäuftes Auftreten von Nierenzellkarzinomen bei adulter polyzystischer Nierendysplasie, tuberöser Sklerose und von Hippel-Lindau-Syndrom, ebenso sind hier häufiger bilaterale und multifokale Tumoren anzutreffen. AbstractIntroduction: We report the first known case of bilateral urothelial carcinoma in combination with a bilateral renal cell carcinoma in a patient with polycystic kidney disease. Case report: Unilateral nephrectomy was performed due to a tumor of the renal pelvis. The pathologic specimen revealed an occult renal cell carcinoma. Five months later the other kidney was removed because of another tumor of the renal pelvis. Once again the pathologic specimen showed a renal cell carcinoma. Conclusions: The coincident occurrence of transitional cell carcinoma of the renal pelvis and renal cell carcinoma is rare. More often, bilateral renal cell carcinomas can be found. In these cases, nephron-sparing techniques are performed with increasing frequency. Renal cell carcinomas -both bilateral and moltifocal -frequently occur in adult polycystic kidney disease, tuberous sclerosis and von Hippel-Lindau syndrome, whereas this is not the case with urothelial carcinoma.

show abstract

Acquired Renal Cystic Disease and Adenocarcinoma following Renal Transplantation – A Current Urologic Perspective

Cited by 12 publications

References 28 publications

Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study

Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study

Acquired cystic kidney disease

Beidseitiges Urothelkarzinom in Kombination mit beidseitigem Nierenzellkarzinom

Contact Info

Product

Resources

About