Acquired cutis laxa associated with multiple myeloma

Scott, M. A.

doi:10.1001/archderm.112.6.853

Cited by 14 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[5][6][7] At least 10 patients have been described in the literature as having ACL associated with multiple myeloma ( Table 1). [8][9][10][11][12][13][14][15][16] Our patient's cutaneous laxity distribution is consistent with descriptions of prior cases. In contrast to prior reports, this is the first case, to our knowledge, of ACL due to myeloma associated with the clinical presentation of GAlike plaques.…”

Section: Commentsupporting

confidence: 84%

Generalized Acquired Cutis Laxa Associated With Multiple Myeloma With Biphenotypic IgG- λ and IgA-κ Gammopathy Following Treatment of a Nodal Plasmacytoma

New

Callen²

2011

Arch Dermatol

View full text Add to dashboard Cite

Background: Cutis laxa is a rare dermatosis that can be inherited or acquired. The acquired form is rare and has been associated with various conditions, including multiple myeloma, monoclonal gammopathy of undetermined significance, and heavy chain deposition disease. Observations: We describe a 48-year-old man who developed generalized cutis laxa over a 4-year duration. There were no preceding skin changes except for a history of erythematous plaques with granuloma annulare-like features on his buttocks and lateral hips. He underwent treatment of an axillary lymph node plasmacytoma with surgery and radiation 4 years prior to his cutaneous changes and had been clinically monitored with a diagnosis of monoclonal gammopathy of unknown significance (MGUS). Cutaneous manifestations prompted a systemic evaluation demonstrating a persistent monoclonal IgG-M-spike on immunofixation electrophoresis and lytic bone lesions. He was later found to have biphenotypic IgG-and IgA-multiple myeloma. Conclusions: Multiple myeloma, plasma cell dyscrasia, and heavy-chain deposition disease have been very rarely reported to be associated with acquired cutis laxa (ACL). Findings in our patient support the hypothesis that paraproteinemia is a cause of ACL through immunologic destruction of elastic fibers manifesting as granuloma annulare-like plaques. Evaluation for an underlying gammopathy is essential for the workup of a patient with new-onset ACL.

show abstract

Section: Commentsupporting

confidence: 84%

Generalized Acquired Cutis Laxa Associated With Multiple Myeloma With Biphenotypic IgG- λ and IgA-κ Gammopathy Following Treatment of a Nodal Plasmacytoma

New

Callen²

2011

Arch Dermatol

View full text Add to dashboard Cite

show abstract

“…In an earlier report of acral localized acquired cutis laxa, 3 similar clinical features were described, but the histological examination for amyloid was not described. Other reports of acquired cutis laxa in association with myeloma‐associated systemic amyloidosis (four cases) have described generalized, rather than localized, changes 4–7 …”

Section: Discussionmentioning

confidence: 94%

Myeloma‐associated systemic amyloidosis presenting with acquired digital cutis laxa‐like changes

et al. 2002

View full text Add to dashboard Cite

A 59-year-old woman presented with a 6-year history of lax skin on the distal fingers of both hands, as well as a recent increase in the size of her tongue. Histopathology of skin from her distal finger showed amyloid deposition and bone marrow biopsy revealed an underlying plasma cell dyscrasia. Initial treatment with cyclophosphamide, vincristine, adriamycin and methylprednisolone has produced a significant reduction in the swelling of both her hands and tongue. Acquired digital cutis laxa-like changes are a rare cutaneous manifestation of systemic amyloidosis.

show abstract

“…Most of the cases reported in the literature refer to the generalized form or type I, which may develop in adulthood, usually following episodes of inflammatory dermatoses, hypersensitivity reaction to insect bites or drugs, neoplastic disorders or in association with particular diseases (Table 1). 1–3,7–19 The skin progressively becomes inelastic and redundant, hanging in loose, pendulous folds. The eyelids drop, and face and neck wrinkles give the patients a senile appearance 2,5,7 .…”

Section: Discussionmentioning

confidence: 99%

Acquired localized cutis laxa confined to the face: case report and review of the literature

et al. 2004

View full text Add to dashboard Cite

show abstract

Acquired cutis laxa associated with multiple myeloma

Abstract: Acquired cutis laxa, or generalized elastolysis, is a rare disease. One patient was found to have not only cutis laxa but also multiple myeloma.

Cited by 14 publications

References 0 publications

Generalized Acquired Cutis Laxa Associated With Multiple Myeloma With Biphenotypic IgG- λ and IgA-κ Gammopathy Following Treatment of a Nodal Plasmacytoma

Generalized Acquired Cutis Laxa Associated With Multiple Myeloma With Biphenotypic IgG- λ and IgA-κ Gammopathy Following Treatment of a Nodal Plasmacytoma

Myeloma‐associated systemic amyloidosis presenting with acquired digital cutis laxa‐like changes

Acquired localized cutis laxa confined to the face: case report and review of the literature

Contact Info

Product

Resources

About