Acquired and genetic susceptibility to cervical cancer

Au, William W.; Sierra‐Torres, Carlos H.; Tyring, Stephen K.

doi:10.1016/j.mrrev.2003.05.001

Cited by 30 publications

(21 citation statements)

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“…Given the presence of smoke carcinogenic metabolites in cervical secretions, smoking could increase the risk of CIN3 either by increasing the chance of viral persistence via immune modulation (23,24) or of genomic damage via genotoxins (5,25). Increased risk may be the result of ''geneenvironment'' interactions of genotoxic smoking metabolites and the inherited ability to detoxify them via metabolic pathways (26). Increased HPV prevalence among the most intense and longest duration current smokers is consistent with smoking-mediated immune modulation.…”

Section: Discussionmentioning

confidence: 90%

Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA–Positive Women with Equivocal or Mildly Abnormal Cytology

McIntyre‐Seltman

Castle²,

Guido³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

115

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Background: Smoking is a potential risk factor for cervical cancer and its immediate precursor, cervical intraepithelial neoplasia grade 3 (CIN3), but few studies have adequately taken into account the possible confounding effect of oncogenic human papillomavirus (HPV) infection. Methods: Women (n = 5,060) with minimally abnormal Papanicolaou smears were enrolled in the ASCUS and LSIL Triage Study, a clinical trial to evaluate management strategies, and were seen every 6 months for the 2-year duration of the study. Cervical specimens were tested for HPV DNA using both Hybrid Capture 2 and PGMY09/11 L1 consensus primer PCR with reverse line blot hybridization for genotyping. Multivariate logistics regression models were used to assess associations [odds ratio (OR) with 95% confidence intervals (95% CI)] between smoking behaviors and rigorously reviewed cases of cervical intraepithelial neoplasia grade 3 or cancer (zCIN3) identified throughout the study (n = 506) in women with oncogenic HPV (n = 3,133).

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Section: Discussionmentioning

confidence: 90%

Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA–Positive Women with Equivocal or Mildly Abnormal Cytology

McIntyre‐Seltman

Castle²,

Guido³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

115

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“…In consequence, the high prevalence of HR HPV infection, especially HPV-16, could be one of the causes responsible for the high incidence of CC among women in the department of Cauca, Colombia. We have been conducting studies to elucidate the role of HPV-infection and other cofactors in the development of CC [Au et al, 2003;Sierra-Torres et al, 2003b]. A recent study conducted by our research team provides suggestive evidence indicating that exposure to wood smoke in the kitchen for 16-45 years significantly increases the risk for HSIL (OR ¼ 5.3, 95% CI ¼ 1.90-14.7) [Sierra-Torres et al, 2006].…”

Section: Discussionmentioning

confidence: 99%

Exposure to wood smoke, HPV infection, and genetic susceptibility for cervical neoplasia among women in Colombia

Sierra‐Torres

Arboleda‐Moreno

Orejuela‐Aristizabal

2006

Environ and Mol Mutagen

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Cervical cancer is the second leading cause of death from cancer among women in Colombia (16/100,000). Infection with high-risk human papillomavirus (HPV) plays a major role in the etiology of high-grade squamous intraepithelial lesions (HSILs). Exposure to chemical agents may be a cofactor for tumor induction, and individual genetic differences in the metabolism of these chemical agents may affect the susceptibility of individuals towards the development of HSIL. In this case-control study, a total of 91 cases with HSIL and 92 healthy controls, frequency-matched by age and place of origin, were recruited, and their frequencies of CYP2E1, GSTM1, and GSTT1 polymorphism were determined. We then evaluated the association of these polymorphisms, by themselves and in combination with wood smoke exposure and HPV-infection status, with the risk of HSIL. The results indicate that GSTM1 and GSTT1 polymorphism were not associated with HSIL, although a small increase in risk was observed for individuals who were GSTT1 null (OR = 1.4, 95% CI = 0.57-3.44). Contrary to other investigations, the c2/c2 variant of the CYP2E1 gene was associated with a significant increase in risk after adjusting for wood smoke exposure (OR = 6.3, 95% CI = 1.10-36.38) or wood smoke exposure and HPV-infection status (OR = 10.7, 95% CI = 1.76-65.58). Wood smoke exposure also increased the risk of HSIL among CYP2E1 c2/c2 HPV-positive women (OR = 3.3, CI = 0.50-22.50); however, the increase did not achieve statistical significance. Our study provides tantalizing evidence that genetic differences in the metabolism of wood smoke carcinogens, particularly metabolism by CYP2E1, may confer susceptibility for HSIL development. Further investigations with larger populations will be needed to confirm this association, which may provide important information for improving cervical cancer prevention programs.

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“…Multiple sexual partners among young adults can increase the risk of acquiring human papillomavirus (HPV), 19,20 which is implicated in 99% of cervical cancer cases.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Cervical Cancer in Criminal Justice Settings

Binswanger

Mueller²,

Clark³

et al. 2011

Journal of Women's Health

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Background: Women in criminal justice settings have an increased prevalence of cervical cancer compared with the general population. However, little is known about abnormal cervical cancer screening results among women in jail and community-based criminal justice settings. Thus, the aims of this study were to compare the prevalence of self-reported abnormal Papanicolou (Pap) test results in women in jail and under community criminal justice supervision and to examine factors associated with abnormal Pap tests in these criminal justice settings. Methods: We analyzed data from two cross-sectional surveys of women in jails and community corrections in two Southern cities (n = 380) about their history of abnormal Pap tests and risk factors for cervical cancer. Univariate analyses (analysis of variance [ANOVA] and chi-square) and a binary logistic regression analysis were conducted to test associations between a history of abnormal Pap testing and factors known to be associated with cervical cancer. Results: Nearly half of the women surveyed (n = 163, 43%) reported ever having an abnormal Pap test. There was a high prevalence of risk factors for cervical cancer among women with and without an abnormal Pap test. After controlling for age and race, there were significant associations between an abnormal Pap test and inconsistent use of barrier protection (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.18-3.43), having a history of gynecologic infections (OR 1.68, 95% CI 1.05-2.67), and having a history of sexually transmitted diseases (OR 1.92, 95% CI 1.17-3.15). Conclusions: Women in jail and under community justice supervision reported a high prevalence of risk factors for cervical cancer. Because of their high prevalence of abnormal Pap testing, women in criminal justice settings may be appropriate targets for improved cervical cancer screening, prevention with human papillomavirus (HPV) vaccination, risk reduction education, and treatment.

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Acquired and genetic susceptibility to cervical cancer

Cited by 30 publications

References 11 publications

Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA–Positive Women with Equivocal or Mildly Abnormal Cytology

Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA–Positive Women with Equivocal or Mildly Abnormal Cytology

Exposure to wood smoke, HPV infection, and genetic susceptibility for cervical neoplasia among women in Colombia

Risk Factors for Cervical Cancer in Criminal Justice Settings

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