Acquired Acrodermatitis Enteropathica

George, Anu Anna; Mishra, Ajay Kumar; Sahu, Kamal Kant; Sargent, Jennifer

doi:10.1016/j.amjmed.2020.09.011

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Acrodermatitis enteropathica dermatitis is characterized by initial vesiculobullous lesions, which desquamate and result in erythematous plaques. Histopathological findings of epidermal pallor, psoriasiform hyperplasia, and focal dyskeratosis can aid in the diagnosis 5,6 . Epidermal pallor characteristic of nutritional deficiencies was not seen in our patient, but chronic lesions can have psoriasiform features.…”

Section: Discussionmentioning

confidence: 51%

“…Histopathological findings of epidermal pallor, psoriasiform hyperplasia, and focal dyskeratosis can aid in the diagnosis. 5,6 Epidermal pallor characteristic of nutritional deficiencies was not seen in our patient, but chronic lesions can have psoriasiform features.…”

Section: Discussionmentioning

confidence: 58%

“…[2][3][4] Above that, supportive interventions have the potential to increase patient activation. 5,6 To find out whether studies assessed patient activation in patients who underwent pancreatic surgery, we performed a systematic review on patient activation in the perioperative setting (unpublished data). Of 39 included studies, no study addressed patient activation in patients with interventions on the pancreas.…”

Section: High Levels Of Activation In Patients With Surgical Diseases...mentioning

confidence: 99%

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Acrodermatitis Enteropathica–Like Dermatosis After Whipple Procedure

et al. 2021

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Z inc is a dietary trace element. Eightysix percent of the total zinc is found in bone and skeletal muscle, 4.2% in the skin, and 3.4% in the liver. Zinc has structural, regulatory, and catalytic functions in proteins. Nutritional deficiencies resulting from inadequate diet, impaired absorption, and defective metabolism can result in distinctive cutaneous manifestations. [1][2][3] CASE DESCRIPTIONWe present a 43-year-old female patient with a medical history of insulin-dependent type 2 diabetes mellitus, hypertension, and surgical history of Whipple procedure 5 years ago for both chronic pancreatitis and pancreatic trauma. She presented with a desquamating LETTERS TO THE EDITOR e60 www.pancreasjournal.com

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 58%

Section: High Levels Of Activation In Patients With Surgical Diseases...mentioning

confidence: 99%

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Acrodermatitis Enteropathica–Like Dermatosis After Whipple Procedure

et al. 2021

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“…Left untreated, acrodermatitis enteropathica is fatal within the first few years of life [125] Acrodermatitis enteropathica patients usually manifest symptoms early in life [1] in the phase of weaning from breastfeeding [140]. Symptoms include a triad of alopecia, diarrhoea, and dermatitis [141]. Patients may also show growth impairment, psoriasiform lesions (well-defined scaly plaques most often found on the elbows) and frequent infections [1].…”

Section: Inherited Zinc Deficiency Acrodermatitis Enteropathica: Diag...mentioning

confidence: 99%

Role of zinc in health and disease

Stiles,

Ferrao,

Mehta

2024

Clin Exp Med

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This review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. Zinc cannot be stored in significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport dietary zinc ions from the duodenum into the enterocyte, ZnT1 transports zinc ions from the enterocyte into the circulation, and ZnT5B (bidirectional zinc transporter) facilitates endogenous zinc secretion into the intestinal lumen. Putative promoters of zinc absorption that increase its bioavailability include amino acids released from protein digestion and citrate, whereas dietary phytates, casein and calcium can reduce zinc bioavailability. In circulation, 70% of zinc is bound to albumin, and the majority in the body is found in skeletal muscle and bone. Zinc excretion is via faeces (predominantly), urine, sweat, menstrual flow and semen. Excessive zinc intake can inhibit the absorption of copper and iron, leading to copper deficiency and anaemia, respectively. Zinc toxicity can adversely affect the lipid profile and immune system, and its treatment depends on the mode of zinc acquisition. Acquired zinc deficiency usually presents later in life alongside risk factors like malabsorption syndromes, but medications like diuretics and angiotensin-receptor blockers can also cause zinc deficiency. Inherited zinc deficiency condition acrodermatitis enteropathica, which occurs due to mutation in the SLC39A4 gene (encoding ZIP4), presents from birth. Treatment involves zinc supplementation via zinc gluconate, zinc sulphate or zinc chloride. Notably, oral zinc supplementation may decrease the absorption of drugs like ciprofloxacin, doxycycline and risedronate.

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“…Zinc deficiency has a proven effect on impaired wound healing [28]. In addition, this trace element contributes to the development of certain diseases associated with nutritional deficiencies (acquired acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, and biotin deficiency) [29][30][31]. Also, an excess of zinc may have a negative impact on human physiology.…”

Section: Zinc Deficiency and Excessmentioning

confidence: 99%

The role of zinc in skin physiology – relevance for the pathogenesis and treatment of vitiligo

Kaczmarek¹,

Wełniak²,

Czajkowski³

2023

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Zinc is a key micronutrient of the skin, where it is responsible, among others, for regulating the processes of melanocyte proliferation, maturation, and differentiation. Recent research has revealed a possible link between zinc levels and the pathogenesis and severity of vitiligo. Zinc deficiency disrupts the activity of immune system cells, which can lead to autoimmunity, melanocyte destruction, and formation of depigmented patches. Numerous studies have found a statistically significant reduction in zinc levels in sera of patients with vitiligo compared to the healthy population. However, the mechanism by which reduced zinc levels might influence the development and severity of depigmented lesions remains unclear. There is no evidence to suggest any benefits of zinc supplementation in vitiligo patients, there are currently no clear guidelines on whether and how zinc supplements should be used in this population. Further research is needed to determine the potential advantage of combining zinc supplementation with commonly used vitiligo treatments.

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Acquired Acrodermatitis Enteropathica

Cited by 4 publications

References 6 publications

Acrodermatitis Enteropathica–Like Dermatosis After Whipple Procedure

Acrodermatitis Enteropathica–Like Dermatosis After Whipple Procedure

Role of zinc in health and disease

The role of zinc in skin physiology – relevance for the pathogenesis and treatment of vitiligo

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