1. Patient age, osteoarticular diseases and comorbidities correlated positively with symptoms of depression. 2. Hospital-based rehabilitation of patients with osteoarticular diseases had a significant impact on reducing the incidence and severity of pain and reducing the consumption of analgesics. 3. Hospital rehabilitation helps eliminate or reduce the severity of symptoms of depression and markedly improves patients' daily functioning.
Zinc is a key micronutrient of the skin, where it is responsible, among others, for regulating the processes of melanocyte proliferation, maturation, and differentiation. Recent research has revealed a possible link between zinc levels and the pathogenesis and severity of vitiligo. Zinc deficiency disrupts the activity of immune system cells, which can lead to autoimmunity, melanocyte destruction, and formation of depigmented patches. Numerous studies have found a statistically significant reduction in zinc levels in sera of patients with vitiligo compared to the healthy population. However, the mechanism by which reduced zinc levels might influence the development and severity of depigmented lesions remains unclear. There is no evidence to suggest any benefits of zinc supplementation in vitiligo patients, there are currently no clear guidelines on whether and how zinc supplements should be used in this population. Further research is needed to determine the potential advantage of combining zinc supplementation with commonly used vitiligo treatments.
IntroductionBackground: Due to an imbalanced redox status, cancer cells generate intrinsically higher levels of reactive oxygen species (ROS), compared to normal cells. Targeting ROS is an important therapeutic strategy for cancer as exemplified by cancer drugs, which induce ROS-dependent synergistic cytotoxicity in gastric cancer cells. The present study was designed to assess the level of selected oxidative stress biomarkers in blood plasma, derived from gastric cancer patients.Material and methodsThe study included the assessment of the oxidative/nitrative biomarkers in blood plasma isolated form 51gastric (adenocarcinoma) cancer patients, compared to a control group of 32 healthy volunteers. Oxidative stress was evaluated using a panel of biomarkers such as plasma protein thiol groups and 3-nitrotyrosine levels as well as indicators of plasma lipid peroxidation, i.e. lipid hydroperoxides (LOOH) and thiobarbituric acid-reactive substances (TBARS). Additionally, the total antioxidant capacity of blood plasma (non-enzymatic capacity of blood plasma, NEAC) was also estimated.ResultsOur results showed that patients with gastric cancer had changed levels of thiol groups (a decrease, p<0.001) and 3-nitrotyrosine (an increase, p<0.0001), LOOH (an increase, p<0.05), TBARS (an increase, p<0.05), NEAC (a decrease, p<0.0001), compared to the control group.ConclusionsThe presented study indicates on a considerable oxidative/nitrative stress in gastric cancer patients. Our pilot study shows that not a single marker, but a biomarkers panel may be a more reliable representation of oxidative stress in patients with gastric cancer.
The aim of the study was to investigate the occurrence of balance disorders in children after mild head trauma. Material and methods: Ninety patients after mild head trauma, aged 7-18 years, were examined on a stabilometric platform 48 h and 12 weeks after injury. The results were compared with 50 healthy children. Seven selected parameters of the stabilogram were measured and analyzed. Results: Children hospitalized after head trauma represented 3.78% of all surgical admissions and 6.6% of all patients after head trauma reporting to the emergency department. The values of all parameters in the entire study group 48 hours after injury were significantly higher than 12 weeks later (p < 0.03), when they decreased to the level of the values in the controls. An inverse relationship between the value of each parameter and the child's age, both in the study group 48 h after injury (p < 0.014) and in the controls (p < 0.008), was found. The values of all parameters in children of the study group aged 11-15 years 48 h after the injury were significantly higher than 12 weeks later (p < 0.05), and significantly higher than in the controls (p < 0.05). The best indicators describing disorders and normalization of body balance control processes were the total path length of center of pressure (SP-EO), the average center of pressure deflection (MA-EO) and the average center of pressure sagittal deflection (MAAP-EO). Conclusions: Minor head trauma clearly, though temporarily, disturbed body postural control, especially affecting children aged 11-15. However, all examined patients 3 months after injury controlled the body balance, like their healthy peers.
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