Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes

Aborehab, Nora M.; Abd-Elmawla, Mai A.; Elsayed, Ahmed; Sabry, Omar M.; Ezzat, Shahira M.

doi:10.1016/j.bioorg.2023.106743

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…The apoptotic effects of Cr were previously noted on a few cancer cell lines, including non-small cell lung cancer (A549), 71 ovarian (OVCA429), 72 and cervical (SiHa) 73 cancers. The literature search also revealed considerable apoptotic effects for CuO NPs on breast (MCF-7), 74 colorectal (HCT-116), 13 and cervical (HeLa) 75 cancer cells.…”

Section: Resultsmentioning

confidence: 89%

Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

Sedky,

Fawzy,

Hassan

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 89%

Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

Sedky,

Fawzy,

Hassan

et al. 2024

RSC Adv.

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“…In the opposite direction, the miRNA155 didn’t show any significant role in modulating the levels of CAMs and pro-inflammatory cytokines IL-1ꞵ and TNF-α. These findings may be attributed to the interrelated role of these markers in several intracellular pathways, so maybe fine-tuned by other miRNAs 40 – 42 .…”

Section: Discussionmentioning

confidence: 98%

Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators

Abd-Elmawla,

Elsabagh,

Aborehab

2023

Sci Rep

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Anti-phospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and miscarriage events. Still, the molecular mechanisms underlying APS, which predisposes to a wide spectrum of complications, are being explored. Seventy patients with primary and secondary APS were recruited, in addition to 35 healthy subjects. Among APS groups, the gene expression levels of XIST, Gab2, and TAK1 were higher along with declined miRNA155 level compared with controls. Moreover, the sera levels of ICAM-1, VCAM-1, IL-1ꞵ, and TNF-α were highly elevated among APS groups either primary or secondary compared with controls. The lncRNA XIST was directly correlated with Gab2, TAK1, VCAM-1, ICAM-1, IL-1ꞵ, and TNF-α. The miRNA155 was inversely correlated with XIST, Gab2, and TAK1. Moreover, ROC curve analyses subscribed the predictive power of the lncRNA XIST and miRNA155, to differentiate between primary and secondary APS from control subjects. The lncRNA XIST and miRNA155 are the upstream regulators of the Gab2/TAK1 axis among APS patients via influencing the levels of VCAM-1, ICAM-1, IL1ꞵ, and TNF-α which propagates further inflammatory and immunological streams. Interestingly, the study addressed that XIST and miRNA155 may be responsible for the thrombotic and miscarriage events associated with APS and provides new noninvasive molecular biomarkers for diagnosing the disease and tracking its progression.

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“…Normally, there is a balance between the demyelination and remyelination processes inside the brain. miRNAs play an essential role in numerous diseases. − One of the main mechanisms that modulates neuronal remyelination is the production of microRNAs, especially miR-146a, which is known to contribute to repairing demyelinated lesions . Consequently, miR-146a is considered a vital target for different therapeutic approaches in treating MS. Nowadays, there are different treatment strategies for MS; however, none of them provide a complete cure for the disease. − Therefore, continuous studies are interested in attaining a therapeutic tool that may give promise for alleviating MS symptoms .…”

Section: Introductionmentioning

confidence: 99%

Modulating miR-146a Expression by Hydrogen Sulfide Ameliorates Motor Dysfunction and Axonal Demyelination in Cuprizone-Induced Multiple Sclerosis

Ghaiad

Abd-Elmawla

Gad

et al. 2023

ACS Chem. Neurosci.

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Multiple sclerosis (MS) is a progressive neuro-inflammatory and neuro-autoimmune disease. Although hydrogen sulfide has recently shown potential therapeutic impacts in different neurological diseases, its effects on MS are still obscure. MiR-146a is considered a vital target for different therapeutic approaches in treating MS. The present study is directed to explore the therapeutic effects of NaHS (hydrogen sulfide donor) on cuprizone-induced MS and to explore whether NaHS can mediate its effects via regulating miR-146a expression. A total of 28 male C57Bl/6 mice were divided into 4 groups; control, cuprizone-intoxicated, NaHS control (100 μmol/kg/day, i.p), and NaHS-treated groups. Intriguingly, NaHS treatment managed to improve locomotor coordination and curb neuronal inflammation and demyelination as evidenced by hematoxylin & eosin, and Luxol fast blue staining and the increased myelin basic protein (MBP) content. Additionally, NaHS reduced interleukin-1 receptorassociated kinase-1 (IRAK-1), nuclear transcription factor kappa B (NF-κB), interleukin (IL)-17, and IL-1β brain levels along with downregulation of miR-146a expression compared with the untreated cuprizone-intoxicated group. Furthermore, NaHS-treated animals revealed much less oxidative stress compared to the untreated animals as evidenced by elevated glutathione and reduced malondialdehyde contents. Altogether, the current work reported that NaHS could improve motor dysfunction and reduce axonal demyelination, oxidative stress, as well as neuro-inflammation in mice with MS. Thus, using H 2 S-releasing compounds could be a promising approach in MS treatment strategies. The mechanism of these beneficial effects may involve the regulation of miR-146a/ NF-κB/IL-1β axis.

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Acovenoside A as a novel therapeutic approach to boost taxol and carboplatin apoptotic and antiproliferative activities in NSCLC: Interplay of miR-630/miR-181a and apoptosis genes

Cited by 5 publications

References 45 publications

Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators

Modulating miR-146a Expression by Hydrogen Sulfide Ameliorates Motor Dysfunction and Axonal Demyelination in Cuprizone-Induced Multiple Sclerosis

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