Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(<scp>ii</scp>) based complex for halting colon cancer: cellular, molecular, and computational investigations

Sedky, Nada K.; Fawzy, Iten M.; Hassan, Afnan; Mahdy, Noha Khalil; Attia, Reem T.; Shamma, Samir N.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin; Mokhtar, Fatma A.; Fahmy, Sherif Ashraf

doi:10.1039/d3ra08779d

RSC Adv.

2024

DOI: 10.1039/d3ra08779d

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Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

Nada K. Sedky,

Iten M. Fawzy,

Afnan Hassan

et al.

Abstract: In the current study, we biosynthesized copper oxide NPs (CuO NPs) utilizing the essential oils extracted from Boswellia carterii oleogum resin, which served as a bioreductant and capping agent with the help of microwave energy.

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Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Shahbaz,

Sabir,

Amin

et al. 2024

Front. Chem.

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MAX phases, characterized as nanolaminates of ternary carbides/nitrides structure, possess a unique combination of ceramic and metallic properties, rendering them pivotal in materials research. In this study, chromium aluminum carbide ternary compounds, Cr2AlC (211), Cr3AlC2 (312), and Cr4AlC3 (413) were successfully synthesized with high purity using a facile and cost-effective sol-gel method. Structural, morphological, and chemical characterization of the synthesized phases was conducted to understand the effects of composition changes and explore potential applications. Comprehensive characterization techniques including XRD for crystalline structure elucidations, SEM for morphological analysis, EDX for chemical composition, Raman spectroscopy for elucidation of vibrational modes, XPS to analyze elemental composition and surface chemistry, and FTIR spectroscopy to ensure the functional groups analysis, were performed. X-ray diffraction analysis indicated the high purity of the synthesized Cr2AlC phase as well as other ternary compounds Cr3AlC2 and Cr4AlC3, suggesting its suitability as a precursor for MXenes production. Additionally, the antimicrobial activity against Candida albicans and biocompatibility assessments against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and HepG2 cell line were investigated. The results demonstrated significant antifungal activity of the synthesized phases against Candida albicans and negligible impact on the viability of E. coli and S. aureus. Interestingly, lower concentrations of Cr2AlC MAX phase induced cytotoxicity in HepG2 cells by triggering intercellular oxidative stress, while Cr3AlC2 and Cr4AlC3 exhibited lower cytotoxicity compared to Cr2AlC, highlighting their potential in biomedical applications.

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Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Shahbaz,

Sabir,

Amin

et al. 2024

Front. Chem.

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show abstract

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Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

Abstract: In the current study, we biosynthesized copper oxide NPs (CuO NPs) utilizing the essential oils extracted from Boswellia carterii oleogum resin, which served as a bioreductant and capping agent with the help of microwave energy.

Cited by 1 publication

References 90 publications

Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

Synthesis and characterization of chromium aluminum carbide MAX phases (CrxAlCx-1) for potential biomedical applications

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