Acoustics at the nanoscale (nanoacoustics): A comprehensive literature review. Part II: Nanoacoustics for biomedical imaging and therapy

Peng, Chang; Chen, Mengyue; Spicer, James B.; Jiang, Xiaoning

doi:10.1016/j.sna.2021.112925

Cited by 10 publications

(13 citation statements)

References 265 publications

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“…As shown in Figure 4A, the higher the concentrations of the solutions, the brighter the color of the thermographic images, indicating that the temperature increase was more obvious. According to previous studies, the temperature at which tumor cells are killed reaches at least 42 C. 12,18,31 The temperature of the PLGA@Au-PD-L1…”

Section: Characteristics Of Photothermal Performancementioning

confidence: 99%

“…It can be connected to the targeting mediator to achieve accurate positioning and target imaging, enabling precision treatment under the effect of drugs. 11,12 Poly(lactic-co-glycolic acid) (PLGA) is a polymeric biomaterial that has been extensively used in nanomedicine. PLGA has good biocompatibility and controllable biodegradability; therefore, it can be used in in vivo drug delivery systems and imaging contrast agents.…”

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confidence: 99%

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Using anti‐PD‐L1 antibody conjugated gold nanoshelled poly (Lactic‐co‐glycolic acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal/chemo combination therapy of triple negative breast cancer

Jiang,

Zhou,

Zheng

et al. 2023

J Biomedical Materials Res

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Triple negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and it is difficult to progress through traditional chemotherapy. Therefore, the treatment of TNBC urgently requires agents with effective diagnostic and therapeutic capabilities. In this study, we obtained programmed death‐ligand 1 (PD‐L1) antibody conjugated gold nanoshelled poly(lactic‐co‐glycolic acid) (PLGA) nanocapsules (NCs) encapsulating doxorubicin (DOX) (DOX@PLGA@Au‐PD‐L1 NCs). PLGA NCs encapsulating DOX were prepared by a modified single‐emulsion oil‐in‐water (O/W) solvent evaporation method, and gold nanoshells were formed on the surface by gold seed growth method, which were coupled with PD‐L1 antibodies by carbodiimide method. The fabricated DOX@PLGA@Au‐PD‐L1 NCs exhibited promising contrast enhancement in vitro ultrasound imaging. Furthermore, DOX encapsulated in NCs displayed good pH‐responsive and photo‐triggered drug release properties. After irradiating 200 μg/mL NCs solution with a laser for 10 min, the solution temperature increased by nearly 23°C, indicating that the NCs had good photothermal conversion ability. The targeting experiments confirmed that the NCs had specific target binding ability to TNBC cells overexpressing PD‐L1 molecules. Cell experiments exhibited that the agent significantly reduced the survival rate of TNBC cells through photochemotherapy combination therapy. As a multifunctional diagnostic agent, DOX@PLGA@Au‐PD‐L1 NCs could be used for ultrasound targeted contrast imaging and photochemotherapy combination therapy of TNBC cells, providing a promising idea for early diagnosis and treatment of TNBC.

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Section: Characteristics Of Photothermal Performancementioning

confidence: 99%

mentioning

confidence: 99%

Using anti‐PD‐L1 antibody conjugated gold nanoshelled poly (Lactic‐co‐glycolic acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal/chemo combination therapy of triple negative breast cancer

Jiang,

Zhou,

Zheng

et al. 2023

J Biomedical Materials Res

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“…Cell breakdown can be achieved through lysing of outer cell vesicles. Cell disintegration can be achieved through SAW in which Rayleigh waves generated on the surface of the substrate with alternating current are applied through an interdigit electrode transducer [22]. When the SAW wave interacts with the liquid droplets as shown in Figure 1, the wave will produce acoustic pressure in the liquid medium and the electrical components in the wave produce Maxwell electrical pressure between the substrate surface and the liquid.…”

Section: Experimental Set Up 21 Lysing Mechanismmentioning

confidence: 99%

Analysis of Extracellular Vesicles Lysing using Surface Acoustic Wave Resonator

Zainal

Jamaludin

Buyong

et al. 2022

ARASET

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The integration of a Y-channel microfluidic system with an annular SAW device developed using MEMS technology has built an efficient platform for mixing and lysing of extracellular vesicles. The travelling SAW used in this study operating at a frequency of 50 MHz is capable of generating surface acoustic waves stream on a liquid sample inside a Y-chamber. At a height of 80µm the PDMS chamber and a liquid sample flow rate of 10µl/min can produce a mixing method that is able to generate gas bubbles that cause the occurrence of microcavities which are the agents of the extracellular vesicle lysing mechanism. This method of rupturing extracellular vesicles through cavitation techniques results in cell rupture through a combination of shear force and pressure changes without destroying proteins and nucleic acids. The Bradford assay is used to observe the increased presence of proteins resulting from the rupture of extracellular vesicles after exposure to acoustic waves. Based on the results, it can be concluded that the most optimal SAW exposure time and power is at 20dBM and 60 seconds. Through this test it can also be observed that a longer exposure period will generate heat which results in the degradation of the proteins that come out of the extracellular vesicles. It can be concluded that the results of this study prove that mechanical method of integrating an annular -SAW device and a Y-channel PDMS microfluidic chamber for micro-mixing, the analysis of biological cells and lysing mechanism can be achieved more effectively compared to conventional methods.

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“…This review complements other recent reviews on subfields of acoustics (e.g., acoustofluidics, 6 nanoacoustics, 7,8 particle manipulation, 9,10 and microbubble acoustics 11 ) in both scale and scope. It is not restricted to any particular scale or single mechanism within acoustics.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Responsive Systems as Components for Smart Materials

et al. 2021

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Smart materials can respond to stimuli and adapt their responses based on external cues from their environments. Such behavior requires a way to transport energy efficiently and then convert it for use in applications such as actuation, sensing, or signaling. Ultrasound can carry energy safely and with low losses through complex and opaque media. It can be localized to small regions of space and couple to systems over a wide range of time scales. However, the same characteristics that allow ultrasound to propagate efficiently through materials make it difficult to convert acoustic energy into other useful forms. Recent work across diverse fields has begun to address this challenge, demonstrating ultrasonic effects that provide control over physical and chemical systems with surprisingly high specificity. Here, we review recent progress in ultrasound–matter interactions, focusing on effects that can be incorporated as components in smart materials. These techniques build on fundamental phenomena such as cavitation, microstreaming, scattering, and acoustic radiation forces to enable capabilities such as actuation, sensing, payload delivery, and the initiation of chemical or biological processes. The diversity of emerging techniques holds great promise for a wide range of smart capabilities supported by ultrasound and poses interesting questions for further investigations.

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Acoustics at the nanoscale (nanoacoustics): A comprehensive literature review. Part II: Nanoacoustics for biomedical imaging and therapy

Cited by 10 publications

References 265 publications

Using anti‐PD‐L1 antibody conjugated gold nanoshelled poly (Lactic‐co‐glycolic acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal/chemo combination therapy of triple negative breast cancer

Using anti‐PD‐L1 antibody conjugated gold nanoshelled poly (Lactic‐co‐glycolic acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal/chemo combination therapy of triple negative breast cancer

Analysis of Extracellular Vesicles Lysing using Surface Acoustic Wave Resonator

Ultrasound-Responsive Systems as Components for Smart Materials

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