Acoustic radiation force imaging (ARFI): A new powerful tool of ultrasound

Yeh, Chang-Chin; Horng, Huann-Cheng; Wang, Peng-Hui

doi:10.1016/j.jcma.2017.07.002

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…The two doctors had been specially trained before doing this work. Hardness of callus was measured by acoustic radiation force impulse (ARFI), and shear wave velocity [14]. However, considering the hardness was related to the extracorporeal shockwave impulse energy, we changed this sign to hardness of callus/impulse energy.…”

Section: Ultrasound Examination and Outcome Measurementsmentioning

confidence: 99%

Analysis of Related Factors Influencing the Efficacy of Extracorporeal Shockwave in the Treatment of Fracture Nonunion: A Prospective Study in Shanghai, China

Wang

et al. 2021

Preprint

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Background: Extracorporeal shockwave is recommended as the first choice for the treatment of fracture nonunion, However, some patients with fracture nonunion have poor response to extracorporeal shockwave therapy. The present study aimed to investigate related factors which may affect the clinical efficacy of extracorporeal shockwave on fracture nonunion. Methods: Ultrasound examination was applied to observe nonunion gap, local blood supply, hardness of callus and hematoma formation before and after extracorporeal shockwave therapy. The patient's condition was followed up for 12 months after extracorporeal shockwave therapy. Four correlations and regression analysis methods were applied to analyze the factors which were correlated the clinical efficacy of extracorporeal shockwave. Receiver-operating characteristic analysis revealed that the cut-off of the fracture nonunion gap was 4.200 mm and the cut-off of the hardness of callus/impulse energy was 2.555. Single factor linear correlation analysis, multi-factor linear regression analysis, single-factor logistic regression analysis were applied. Results: The four ultrasound signs were significantly correlated with extracorporeal shockwave therapy: nonunion gap (r = -0.723; OR = 3.074), local blood supply (r = 0.611; OR = 0.191), hardness of callus/impulse energy (r = -0.510; OR = 19.942), and hematoma formation (r = 0.722; OR = 0.015). Conclusions: Nonunion gap larger than 4.200 mm and hardness of callus/impulse energy larger than 2.555 are risk factors of extracorporeal shockwave therapy outcome, and good local blood supply and effective hematoma formation induced by extracorporeal shockwave therapy are protective factors. By analyzing the related factors of extracorporeal shockwave therapy on fracture nonunion, clinicians may screen out the patients with fracture nonunion who are not suitable for extracorporeal shockwave therapy, and reduce the risk of fracture nonunion.

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Section: Ultrasound Examination and Outcome Measurementsmentioning

confidence: 99%

Analysis of Related Factors Influencing the Efficacy of Extracorporeal Shockwave in the Treatment of Fracture Nonunion: A Prospective Study in Shanghai, China

Wang

et al. 2021

Preprint

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“…In previous years, virtual touch tissue imaging and quantification (VTIQ), a novel two-dimensional shear wave speed (SWS) measurement technique, has been introduced into clinical practice, which not only provides qualitative but also quantitative measurements of the tissue stiffness ( 3 – 5 ). VTIQ is based on the acoustic radiation force imaging method, which transmits ultrasonic pulses in the targeted tissue, resulting in a tissue displacement of 1–20 µm, thereby attenuating the tissues to establish elasticity ( 6 ). Elasticity is a biological and mechanical property, which represents the stiffness of the tumor tissue ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

VTIQ evaluates antitumor effects of NET‑1 siRNA by UTMD in HCC xenograft models

Liang

Shang

et al. 2018

Oncol Lett

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The present study used a virtual touch tissue imaging and quantification (VTIQ) method to investigate the change in elasticity in xenograft tumor tissue models following silencing of the neuroepithelial-transforming protein 1 (NET-1) gene by ultrasound-targeted microbubble destruction (UTMD). A total of 24 xenograft models were established by subcutaneous injection of human hepatocellular carcinoma SMMC-7721 cells in BALB/c female nude mice. Then, NET-1 small interfering RNA (siRNA)-conjugated nanobubbles and a glypican-3 antibody were synthesized. The mean and maximum shear wave speed (SWSmean and SWSmax) in the tumor tissue were measured prior to, during, and following therapy using VTIQ. The growth of the tumor size and survival time were recorded. The levels of NET-1 protein were evaluated by immunohistochemical staining. In addition, tumor, liver and kidney tissues of the nude mice were collected to confirm whether gene transfection treatment was toxic in vivo. In the UTMD delivery gene group, SWSmean was correlated with the maximum diameter of the tumor (r=0.9806, P=0.0194). The immunohistochemical staining data indicated that the level of NET-1 protein in the treated groups was significantly decreased compared with those in the control groups. Additionally, no structural damage was observed in the nude mice liver and kidney tissues following treatment. Therefore, VTIQ measurement identified potential changes in the elastic properties of the tumors, which in turn may be associated with the stages of tumor development. The delivery method, UTMD, improves the antitumor effects of NET-1 siRNA and supports gene transfection as a promising therapeutic strategy.

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