Tumor markers and mature cystic teratoma of the ovary

Lee, Fa‐Kung; Horng, Huann-Cheng; Wang, Peng-Hui

doi:10.1016/j.jcma.2017.08.002

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…According to the findings of the present study, patients with larger tumors were more likely to present with elevated CA 19-9 levels. Tumor size plays an important role in MCTs since larger tumors are frequently related to complications, including the risk of rupture and torsion, as well as the potential of malignant transformation [42]. Thus, an elevation in serum levels of CA 19-9 would supplement the imaging findings in early detection and prediction of the aforementioned complications.…”

Section: Discussionmentioning

confidence: 99%

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Prodromidou¹,

Pandraklakis²,

Loutradis³

et al. 2019

Cureus

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The role of preoperative CA 19-9 levels in patients with ovarian mature cystic teratoma (MCT) and the association of elevated levels of the biomarker with patients' and tumor characteristics were evaluated. Four electronic databases were searched for articles published up to September 2019. Trials that evaluated the significance of elevated CA 19-9 in patients with ovarian MCTs and publications with > 20 patients were considered eligible for inclusion. Seven studies that included 995 patients with an ovarian MCT who were evaluated with elevated (n = 364) or normal (n = 631) CA 19-9 levels were included. Mean tumor size was significantly increased in patients with elevated CA 19-9 levels (p = 0.038). The rate of ovarian torsion was significantly increased in the elevated CA 19-9 group (p = 0.04). The present study highlights the importance of CA 19-9 as a marker in the diagnosis of MCT, and a meta-analysis supports that it could raise a high degree of clinical suspicion of early recognition of torsion and early surgical management due to complications related to increased size. Nonetheless, the diagnostic value of CA 19-9 is still limited and CA 19-9 can still serve only as a supplementary diagnostic tool in patients with MCTs.

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Section: Discussionmentioning

confidence: 99%

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Prodromidou¹,

Pandraklakis²,

Loutradis³

et al. 2019

Cureus

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show abstract

“…Malignant changes in this type of ovarian cyst are in about 1 -2% of patients, and torsion is their most complication (25). Some radiologic features, like ultrasonography, can suggest MCT, but tumor markers alongside the imaging accommodate the diagnosis (8). The majority of signs and symptoms of ovarian cancer are nonspecific.…”

Section: Discussionmentioning

confidence: 99%

“…Mature cystic teratomas are more common in repro-ductive age (7). They may present with different findings in imaging, including Rokitansky nodules, calcifications, palm tree-like protrusion, diffuse or regional high amplitude echoes called intratumoral fat, and dot-dash sign (8). The modality choice of diagnosis is transvaginal ultrasonography (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

The Role of CA19-9 and CA125 in Differentiation of Ovarian Dermoid Cyst and Ovarian Malignancy: A Case-Control Study

Shamshiri Khamene,

Mohammad Khawajah,

Mahboobipour

et al. 2023

Fertil Gynecol Androl

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Background: An ovarian dermoid cyst is one of the most prevalent benign tumors in women of reproductive age. They can get complicated or be mistaken for malignant tumors. Most of the time, their pathology will not be discovered until after surgery. Objectives: Finding the role of CA19-9 and CA125 tumor markers in diagnosing the dermoid cyst before surgery and distinguishing it from the malignant type. Methods: A case-control study was conducted on all cases of dermoid cysts and malignant tumors (both diagnosed by pathology) from 2019 to 2021. Required information such as age, level of tumor markers, size, and whether it is unilateral or bilateral were extracted, and the tumor marker levels were analyzed in benign and malignant groups. Results: In this study, 95 cases of ovarian cysts and 85 control of malignant ovarian tumors were included. The mean level of CA19-9 and CA125 in the patients with dermoid cysts was 32.26 ± 5.45 units/mL and 31.37 ± 4.77 units/mL, respectively. In the malignant ovarian tumor group, the average level of CA19-9 and CA125 was equal to 9.56 ± 3.54 units/mL and 233.79 ± 54.57 units/mL, respectively. CA19-9 level was significantly higher in the dermoid cyst group (P-value < 0.001). CA125 level was significantly elevated among the malignant group (P-value < 0.001). It was observed that there was a significant relationship between the level of CA19-9 with the size of the cyst and the level of CA125 with the age of the patients. No significant relationship was found between the level of tumor markers and whether they were unilateral or bilateral. Conclusions: Regarding the correlation between the cyst size and CA19-9 in the comparison of the two groups, this tumor marker may be a suitable diagnostic marker in benign ovarian cysts along with ultrasound.

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Update on the differential diagnosis of gynecologic organ-related diseases in women presenting with ascites

Cho

Kung

et al. 2019

Taiwanese Journal of Obstetrics and Gynecology

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Tumor markers and mature cystic teratoma of the ovary

Cited by 4 publications

References 14 publications

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

The Role of CA19-9 and CA125 in Differentiation of Ovarian Dermoid Cyst and Ovarian Malignancy: A Case-Control Study

Update on the differential diagnosis of gynecologic organ-related diseases in women presenting with ascites

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