Acoustic Parameters for Optimal Ultrasound-Triggered Release from Novel Spinal Hardware Devices

Delaney, Lauren J; Başgül, Cemile; MacDonald, Daniel W.; Fitzgerald, Keith; Hickok, Noreen J.; Kurtz, Steven M.; Forsberg, Flemming

doi:10.1016/j.ultrasmedbio.2019.10.002

Cited by 5 publications

(18 citation statements)

References 38 publications

(55 reference statements)

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“…AM PEEK/PEKK for spinal implants were evaluated in six studies in which FFF was the AM method for all 27‐31,42 (Figure 5). Specifically, intervertebral devices ( n = 3), 27,28,42 spinal clips designed for spinal fusion infection ( n = 2) 30,31 and cylindrical implants ( n = 1) 29 were evaluated in these six studies. Furthermore, AM PEEK/PEKK was investigated for cranio‐maxillofacial (CMF) implants and reconstructions in six studies 4,6,40,49,56,58 .…”

Section: Resultsmentioning

confidence: 99%

“…AM PAEK is investigated for dental (a), reprinted from Prechtel et al 35 with permission from Springer, spinal (b,c), reprinted from Delaney et al 30 (b) and Basgul et al 27 (c) with permission from Elsevier, cranial (d), reprinted from Berretta et al 49 with permission from Elsevier, and chest reconstruction surgeries (e), reprinted from Kang et al 2 with permission from Springer Nature, via FFF (a,b,c,e) and SLS (d) systems…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, infection prevention was investigated conceptually by a spinal clip design 30,31 and antibacterial drug release via biodegradable polymer coating on PAEK for implants, 33 however these studies do not include in vivo studies and in vitro bioactivity studies. Lau et al 33 coated FFF PEEK disks with ampicillin and/or vancomycin salts using biodegradable polylactic‐co‐glycolicacid (PLGA) and then investigated the antibacterial activities of samples.…”

Section: Resultsmentioning

confidence: 99%

“…They indicated antibacterial activities of FFF PEEK coated with antibiotics were observed up to 28 days and suggested that 50% of each antibiotic agent loaded in FFF PEEK samples proved the most efficient antibacterial performance. To prevent spinal infection, Delaney et al 30,31 developed FFF PEEK clips with a reservoir, which was designed to be loaded with antibiotics and a controlled drug release mechanism was assured via ultrasound trigger. They indicated the levels of antibiotics will be released via FFF PEEK clips are sufficient to prevent the infection.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, AM PAEKs were designed to treat and prevent the possible postoperative infection by antibacterial drugs incorporated into biodegradable polymer coating onto PAEK 33 . Alternatively, AM enabled a FFF spinal device to prevent infection for spinal surgeries by allowing for controlled drug released postsurgery 30,31 . In vitro and in vivo studies in this area will lead researchers for infection prevention effort postsurgery via AM PAEK.…”

Section: Discussionmentioning

confidence: 99%

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Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

et al. 2021

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Additive manufacturing (AM) of high temperature polymers, specifically polyaryletherketones (PAEK), is gaining significant attention for medical implant applications. As 3D printing systems evolve toward point of care manufacturing, research on this topic continues to expand. Specific regulatory guidance is being developed for the safe management of 3D printing systems in a hospital environment. PAEK implants can benefit from many advantages of AM such as design freedom, material and antibacterial drug incorporation, and enhanced bioactivity provided by cancellous bone‐like porous designs. In addition to AM PAEK bioactivity, the biomechanical strength of 3D printed implants is crucial to their performance and thus widely studied. In this review, we discuss the printing conditions that have been investigated so far for additively manufactured PAEK implant applications. The effect of processing parameters on the biomechanical strength of implants is summarized, and the bioactivity of PAEKs, along with material and drug incorporation, is also covered in detail. Finally, the therapeutic areas in which 3D printed PAEK implants are investigated and utilized are reviewed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

et al. 2021

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In Vitro and In Vivo Evaluation of Ultrasound‐Triggered Release From Novel Spinal Device

Delaney

Isguven

Hilliard

et al. 2023

J of Ultrasound Medicine

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ObjectivesBacterial infection following spinal fusion is a major clinical concern with up to 20% incidence. An ultrasound‐triggered bulk‐release system to combat postsurgical bacterial survival was designed and evaluated.MethodsPolylactic acid (PLA) clips were loaded with vancomycin (VAN) and microbubbles (Sonazoid, GE HealthCare) in vitro. Stability was determined over 14 days. VAN‐loaded clips were submerged in water and insonated using a Logiq E10 scanner (GE HealthCare) with a curvilinear C6 probe. Doppler‐induced VAN release was quantified using spectrophotometry. For in vivo testing, clips were loaded with methylene blue (MeB) solution and Sonazoid. These clips were implanted into a rabbit along the spine at L2 and L5, as well as a pig at L1 and L3, then insonated in Doppler mode using the C6 probe.ResultsSonazoid microbubbles were better preserved when incubated in VAN compared with distilled water at 4°C, 25°C, and 37°C incubation temperatures (P = .0131). Contrast enhancement was observed from both solutions when incubated at 4°C storage conditions. Insonated clips achieved average cumulative VAN release of 101.8 ± 2.8% (81.4 ± 2.8 mg) after 72 hours. Uninsonated clips had only 0.3 ± 0.1% (0.3 ± 0.1 mg) average cumulative VAN release (P < .0001). Clips retrieved from the rabbit did not rupture with insonation nor produce MeB staining of surrounding tissues. In the pig, the PLA film was visibly ruptured and MeB tissue was observed following insonation, whereas the uninsonated clip was intact.ConclusionThese results demonstrate ultrasound‐triggered release of an encapsulated prophylactic solution and provide an important proof‐of‐concept for continuing large animal evaluations for translational merit.

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Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches

et al. 2022

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Acoustic Parameters for Optimal Ultrasound-Triggered Release from Novel Spinal Hardware Devices

Cited by 5 publications

References 38 publications

Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

In Vitro and In Vivo Evaluation of Ultrasound‐Triggered Release From Novel Spinal Device

Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches

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