Acoustic Cavitation Leading to the Morphosynthesis of Mesoporous Silica Vesicles

Rana, Rohit Kumar; Mastai, Yitzhak; Gedanken, Aharon

doi:10.1002/1521-4095(20021002)14:19<1414::aid-adma1414>3.0.co;2-f

Cited by 188 publications

(129 citation statements)

References 11 publications

(15 reference statements)

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“…In order to prepare vesicular structures using these surfactants, special treatments have to be used to generate the vesicles. [11,21] In contrast to hydrogenated surfactants, partially fluorinated surfactants are prone to form low-curvature structures such as discs, bilayers, and vesicles. [22] We first reported the formation of vesicular silica with mesoporous shells by using the partially fluorinated surfactant CF 3 (CF 2 ) 7 (CH 2 ) 2 PyCl as a template, although in that case the walls seem to be formed from packed micelles rather than bilayers of surfactant.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Inorganic and Organic–Inorganic Hybrid Hollow Particles Using a Cationic Surfactant with a Partially Fluorinated Tail

Tan

Vyas

Lehmler

et al. 2007

Adv Funct Materials

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A new partially fluorinated cationic surfactant, 1‐(10‐perfluorooctyldecyl)pyridinium bromide monohydrate, is synthesized and used as the template for mesoporous ceramic and inorganic–organic hybrid particles. Several hydrolyzed alkoxide precursors are shown to co‐assemble with this surfactant to form hollow vesicle‐like particles, and the effect of changing the alkoxide chemical structure on the formation of these particles is examined. Tetramethoxysilane produces cubic or columnar particles without hollow cavities, but all other tetra‐n‐alkoxysilanes tested up to the n‐butoxide produce hollow particles. As the alkoxide length increases, the shell structure changes from multilayered (with Si(OC2H5)4) to a single thin layer (with Si(OC3H7)4) to a single thick layer (with Si(OC4H9)4). The stability of the fluorocarbon bilayers allows similar vesicular structures to be obtained in organic–inorganic hybrids prepared with bridged alkoxysilanes. Ethylene‐bridged silanes display similar structures to tetraalkoxysilanes. However, the hollow structures appear to partially collapse when the bridging chain is too long (octylene) and no hollow particles are formed with bis(trialkoxysilylpropyl)amines.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Inorganic and Organic–Inorganic Hybrid Hollow Particles Using a Cationic Surfactant with a Partially Fluorinated Tail

Tan

Vyas

Lehmler

et al. 2007

Adv Funct Materials

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“…More recently, vesicular hierarchical structures have been observed through electrostatic assembly pathways using alkyl ammonium ion surfactants as the structure director, but in these cases it was necessary to use high-intensity ultrasound [22,23] or co-surfactants [24] to promote vesicle formation. Although these latter methods offer some processing advanWe describe the hierarchical structures of mesostructured silicas assembled from electrically neutral and unsymmetrical Gemini surfactants of the type C n H 2n+1 NH(CH 2 ) m NH 2 with n = 10, 12, 14 and m = 3, 4.…”

Section: Introductionmentioning

confidence: 99%

Lamellar Mesostructured Silicas with Chemically Significant Hierarchical Morphologies

Karkamkar¹,

Kim²,

Mahanti³

et al. 2004

Adv Funct Materials

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We describe the hierarchical structures of mesostructured silicas assembled from electrically neutral and unsymmetrical Gemini surfactants of the type CnH2n+1NH(CH2)mNH2 with n = 10, 12, 14 and m = 3, 4. As expected for Gemini surfactants with an all anti‐chain configuration and a packing parameter near 1.0, lamellar framework structures are formed, regardless of the length of the alkyl chain (n) and the number of carbon atoms (m) linking the two amino group centers. However, different layer curvatures and levels of hierarchical structure are observed depending on the delicate balance between the hydrophilic interactions at the surfactant head group–silica interface and the hydrophobic interactions between the surfactant alkyl groups. For Gemini derivatives with n = 12 or 14 and m = 3 or 4, well‐expressed hierarchical vesicles are formed that are analogous to those assembled previously from Gemini surfactants with m = 2. However, for n = 10, a new coiled slab structure (m = 3) and an onion‐like core–shell structure (m = 4) are formed. In addition, a previously unobserved stripe‐like silica structure is obtained from a C012+2+0 Gemini surfactant in combination with an α,ω‐diamine co‐surfactant. The relative stability of these hierarchical structures depends on the delicate competition between the long‐range elastic forces occurring in the hydrophobic region of the assembled surfactant and the short‐range chemical forces in the hydrophilic moiety. Lamellar silicas with hierarchical vesicular structures, the new coiled slab, and stripe‐like phases promise to be chemically significant morphologies, because they can minimize the framework pore length and provide optimal access to the framework walls under diffusion‐limited conditions.

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“…Silica nanospheres prepared from noncovalently bound organic templates (surfactant, polymers, supramolecular arrays), acoustic cavitation, electrospraying, spray drying, self assembly, freeze thawing, supercritical fluid technology, heterophase polymerization with sol-gel and surface living polymerization process have been reported [17][18][19][20][21][22][23][24]. Solgel derived silica nanospheres were used to encapsulate antibiotics, analgesic, pancreatic islets, dyes and perfumes.…”

Section: Introductionmentioning

confidence: 99%

Silica‐Coated Liposomes for Insulin Delivery

Dwivedi

Arunagirinathan

Sharma

et al. 2010

Journal of Nanomaterials

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Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis. The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy. The native state of insulin present in the formulation was evident from Confocal MicroRaman spectroscopy. Silica coat enhances the stability of insulin-loaded delivery vehicles. In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels.

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Acoustic Cavitation Leading to the Morphosynthesis of Mesoporous Silica Vesicles

Cited by 188 publications

References 11 publications

Synthesis of Inorganic and Organic–Inorganic Hybrid Hollow Particles Using a Cationic Surfactant with a Partially Fluorinated Tail

Synthesis of Inorganic and Organic–Inorganic Hybrid Hollow Particles Using a Cationic Surfactant with a Partially Fluorinated Tail

Lamellar Mesostructured Silicas with Chemically Significant Hierarchical Morphologies

Silica‐Coated Liposomes for Insulin Delivery

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