Acne vulgaris and antimicrobial resistance: a review

Abstract

Background: Acne is a chronic inflammatory disease of skin follicle on the face, which affects almost 85% youngsters and adolescents. The most common causative agent is Propionibacterium species. The evaluation of antimicrobial activity of turmeric and neem, two Indian herbs in facial cosmetics may provide a better treatment option for acne. Objective: The review was to evaluate the microbiological characterization of Propionibacteria isolates from acne vulgaris cases and to identify the antimicrobial action against common antibiotics in use and different herbal extracts. Method: A regimented search in the online databases such as PubMed, EMBASE, Google scholar, scopus and so on was done to identify relevant studies according to search strategies. Other search engines were also used, but could not extract relevant articles or studies form those electronic data bases. From the electronic search, 125 articles were identified, after title and abstract review, 96 articles were retained as eligible. A full-text evaluation resulted in 23 studies to be included for review. Conclusion: The results suggests that Propionibacterium acnes is the main causative agent for pustular acne vulgaris and metronidazole was expectedly sensitive to P. acnes, whereas erythromycin and Clindamycin is emerging resistance.

Comprehensive evaluation of antiacne properties: HPLC analysis of crude extract from Aloe buettneri leaves against Cutibacterium acnes-induced acne

“…Various treatments, such as anti-seborrheic agents, anti-androgens, antimicrobials, anti-inflammatories, antioxidants, and keratolytics, are employed against acne (Araviiskaia and Dréno, 2016). However, these treatments may lead to drug resistance (Varghese, 2020), and some pose a risk of toxicity (Akhavan and Bershad, 2003). The primary adverse effects of topical acne treatments encompass erythema, desquamation, itching, burning, and increased skin sensitivity (Otlewska et al, 2020).…”

Phytochemical Screening, Antimicrobial and Antioxidant Activities of Aloe buettneri, Mitracarpus scaber and Hannoa undulata used in Togolese Cosmetopoeia

“…C. acnes stimulates the production of superoxide anions in skin cells which initiate skin inflammation 6 . C. acnes is one of the main antibiotic-resistant micro-organisms responsible of acne lesions 7,8 . There are several ways through which microorganisms can lead disruption of the follicular epithelium and the inflammatory response.…”