Acne in hirsute women

Lumezi, Besa Gacaferri; Pupovci, Hatixhe Latifi; Berisha, Violeta Lokaj; Goci, Aferdita; Gerqari, Antigona

doi:10.5114/pdia.2014.47118

Cited by 7 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The underlying endocrine disorder is rare in female with adult-onset acne. Systemic signs of hyperandrogenemia, such as irregular menstrual cycles or hirsutism, may indicate the presence of endocrine condition and need further diagnosis [7, 28]. It is probable that acne is a result of exacerbated response of the pilosebaceous unit to the normal circulating androgens [29].…”

Section: Role Of Hormonesmentioning

confidence: 99%

The possible role of diet in the pathogenesis of adult female acne

Romańska-Gocka¹,

Woźniak²,

Kaczmarek-Skamira³

et al. 2016

pdia

View full text Add to dashboard Cite

Acne in adults is a chronic, increasingly common disease, especially among women. It differs in pathogenesis and clinical presentation from adolescent acne. Acne in adults is associated with Western diet, defined as high consumption of milk, high glycemic load and high calorie intake. Metabolic signals of this diet result in a significant increase in insulin/insulin growth factor 1 serum level and consequently in the molecular interplay of mammalian target of rapamycin complex 1 kinase (mTORC1)/forkhead box protein 1 (FoxO1) mediated nutrient signaling, leading to increased proliferation of keratinocytes, increased lipogenesis and sebum production and finally to aggravation of acne.

show abstract

Section: Role Of Hormonesmentioning

confidence: 99%

The possible role of diet in the pathogenesis of adult female acne

Romańska-Gocka¹,

Woźniak²,

Kaczmarek-Skamira³

et al. 2016

pdia

View full text Add to dashboard Cite

show abstract

“…Both idiopathic hirsutism and PCOS account for 95% of hirsutism [1]. Because increased androgen levels may also lead to pilosebaceous responses, such as acne, excessive sebum secretion, or diffuse or localized loss of hair, a dermatologic examination is mandatory [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Grading of hirsutism based on the Ferriman-Gallwey scoring system in Kosovar women

Lumezi¹,

Berisha²,

Pupovci³

et al. 2018

pdia

Self Cite

View full text Add to dashboard Cite

IntroductionHirsutism is defined as excess terminal hair that commonly appears in a male pattern in women.AimTo examine severity and distribution of hirsutism with Ferriman-Gallwey visual scoring system in hirsute women in Kosovo.Material and methodsThis prospective study included 160 women, 135 with hirsutism and 25 as a control group. The Ferriman-Gallwey score is used to evaluate hirsutism. The examiner scored the subjects on a scale of 0–4 for terminal hair growth on eleven different body areas according to the Ferriman-Gallwey scoring system. An Ferriman-Gallwey score of 8 or more was considered diagnostic of hirsutism. A thorough physical examination with specific emphasis on signs of virilization (including frontal baldness, loss of female body contours, increased muscularity, acne, clitoromegaly, and atrophy of breast) was done in all patients.ResultsThe positive family history of hirsutism was present in 63.7%. In 51.1% of women with hirsutism, the menstrual cycle was regular, 25.2% had oligomenorrhea, 13.3% amenorrhea, 7.4% dysmenorrhea, 1.5% polymenorrhea and 1.5% oligomenorrhea and dysmenorrhea. The age group with the highest scoring comprised women under 20 years and 20–29 years group with an average value of 23.9 and 24.8, respectively. In our study population, 40% of the patients had an Ferriman-Gallwey score of 3 for the upper lip and 47% of patients had an Ferriman-Gallwey score of 3 for the chin.ConclusionsThe Ferriman-Gallwey scoring system has a great significance and value to establish the diagnosis of hirsutism and is an acceptable screening method.

show abstract

“…Plasma phytosterol levels are affected by their intestinal absorption efficiency, mediated by intestinal lipid transporters Niemann-Pick C1-Like 1 (NPC1L1) (favoring sterol uptake) [ 7 ] and ATP-binding cassette G5 and G8 (ABCG5/ABCG8) transporters (favoring phytosterol efflux from enterocytes back to the lumen) [ 8 , 9 ]. Plasma phytosterols also are affected by hepatic NPC1L1 and ABCG5/ABCG8 transporters [ 10 ], which result in the rapid and near complete biliary excretion of phytosterols. Moreover, increasing phytosterol intake results in a plateau in plasma phytosterol levels, indicating competition of phytosterols for their own absorption [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma Biomarker of Dietary Phytosterol Intake

Lin

Racette

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

BackgroundDietary phytosterols, plant sterols structurally similar to cholesterol, reduce intestinal cholesterol absorption and have many other potentially beneficial biological effects in humans. Due to limited information on phytosterol levels in foods, however, it is difficult to quantify habitual dietary phytosterol intake (DPI). Therefore, we sought to identify a plasma biomarker of DPI.Methods and FindingsData were analyzed from two feeding studies with a total of 38 subjects during 94 dietary periods. DPI was carefully controlled at low, intermediate, and high levels. Plasma levels of phytosterols and cholesterol metabolites were assessed at the end of each diet period. Based on simple ordinary least squares regression analysis, the best biomarker for DPI was the ratio of plasma campesterol to the endogenous cholesterol metabolite 5-α-cholestanol (R2 = 0.785, P < 0.0001). Plasma campesterol and 5-α-cholestanol levels varied greatly among subjects at the same DPI level, but were positively correlated at each DPI level in both studies (r > 0.600; P < 0.01).ConclusionThe ratio of plasma campesterol to the coordinately regulated endogenous cholesterol metabolite 5-α-cholestanol is a biomarker of dietary phytosterol intake. Conversely, plasma phytosterol levels alone are not ideal biomarkers of DPI because they are confounded by large inter-individual variation in absorption and turnover of non-cholesterol sterols. Further work is needed to assess the relation between non-cholesterol sterol metabolism and associated cholesterol transport in the genesis of coronary heart disease.

show abstract

Acne in hirsute women

Cited by 7 publications

References 20 publications

The possible role of diet in the pathogenesis of adult female acne

The possible role of diet in the pathogenesis of adult female acne

Grading of hirsutism based on the Ferriman-Gallwey scoring system in Kosovar women

Plasma Biomarker of Dietary Phytosterol Intake

Contact Info

Product

Resources

About