Acne Clinic: Morphogenesis

Plewig, Gerd; Melnik, Bodo C.; Chen, WenChieh

doi:10.1007/978-3-319-49274-2_4

Cited by 9 publications

(13 citation statements)

References 68 publications

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“…Wall morphology was the same as that of other biopsy‐obtained specimens in previous studies. 2 , 8 , 14 Moreover, the plugs still contained the microorganisms in situ, which were readily observed by light, fluorescence, and SEMs. Malassezia spp .…”

Section: Resultsmentioning

confidence: 90%

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A 1‐min double embedding method for small tissue specimens preserves comedone histology and eliminates the need for punch biopsies

Zheng

Shi

et al. 2022

Skin Research and Technology

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Background It is difficult to preserve the structure and microbial distribution inside comedonal plugs during routine processing. Objective The objective of this study is to determine the optimal method to preserve the comedonal corneum plug structure and inherent microorganisms thereby eliminating the need to perform punch biopsies in relevant studies. Methods Corneum plugs were extracted from comedones of acne vulgaris patients. Primary embedding using either a 2% agarose, 2% agar, 25% gelatin, or 2% agar + 2.5% gelatin solution was subsequently performed and the results compared. The specimens were then fixed, waxed, sectioned, and examined by light, fluorescence, and scanning electron microscopies to observe the structures and microorganisms within the plugs. Results Both the 25% gelatin and 2% agarose solutions successfully preserved the structural integrity of corneum plugs and the inherent microorganisms. When considering other factors such as thermostability, reusability, and convenience, the 25% gelatin solution was the superior choice among the four materials. Conclusion We report a simple and effective method for double embedding comedonal plugs and other small tissue specimens. The technique preserves the structure and microbial distribution in situ within comedonal corneum plugs, eliminates the need for punch biopsies. This method may also be applied to other tiny and fragile tissue specimens, thereby enabling a potentially wide array of future large‐scale investigations and alleviated patients’ pain.

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Section: Resultsmentioning

confidence: 90%

“… 1 Corneum plugs are composed of hyper‐proliferated corneocytes, sebum‐derived lipids, and a variety of microorganisms. 2 The microorganisms and their metabolites, which include toxins and degraded sebaceous lipids, subsequently induce an inflammatory process, which persists throughout the disease course. 3 …”

Section: Introductionmentioning

confidence: 99%

A 1‐min double embedding method for small tissue specimens preserves comedone histology and eliminates the need for punch biopsies

Zheng

Shi

et al. 2022

Skin Research and Technology

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“…~ 49 ~ Sociodemographic and medical records were gathered. Answers to fundamental questions concerning health, overall quality of life, and the significance of skin disease to one's life quality were rated on a 5-point category scale [8,9,10] . Higher scores indicate better health or more importance.…”

Section: Methodsmentioning

confidence: 99%

Adult dermatology patients quality of life and acne vulgaris

Reddy¹

2019

Int. J. Dermatol. Venereology Leprosy Sci.

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Background and objectives: To evaluate how adult dermatological patients' life quality is influenced by acne vulgaris. Method:The study conducts a cross-sectional and longitudinal questionnaire survey. About 80 acne vulgaris sufferers are present for visits alongside the doctors. Results obtained utilizing Skindex, a 29item standardized tool to assess how skin diseases affect individuals' life quality. Findings are reported as a total scores, three scale ratings (functioning, emotions, and symptoms), and (average scale score). Results: Acne prone individuals experienced functional and emotional consequences equivalent to psoriasis patients, but minor symptoms (Skindex completely operational scores of 14.9 and 22.8 [P=.08]; emotional marks of 39.2 and 38.9 [P=.95]; and symptomatic mark of 29.5 and 42.1 [P.05]). Over-40s least prone to develop acne improve after three months (43% vs 85%; p<.05) and had higher Skindex ratings. After correcting for gender and the severity of acne as established by dermatologists, elderly people reported a greater impact of acne on peoples lifestyle than the lower age participants. Conclusions: Acne vulgaris negatively impacts sufferers' standard of living. Elderly people have been more impacted by the acne, irrespective of its extent.

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“…6,7 It is pathophysiologically similar to acne conglobata, dissecting cellulitis, and pilonidal disease-the four of which are known as the "follicular occlusion tetrad". 8 Nodules develop granulomatous inflammation over time, which leads to follicle rupture. In severe disease, nodules form sinus tracts that drain to the skin surface.…”

Section: Introductionmentioning

confidence: 99%

“…The disease process is thought to begin with hair follicle occlusion, which causes an inflammatory response that produces the disease's characteristic nodules 6,7 . It is pathophysiologically similar to acne conglobata, dissecting cellulitis, and pilonidal disease—the four of which are known as the “follicular occlusion tetrad” 8 . Nodules develop granulomatous inflammation over time, which leads to follicle rupture.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of sexual dysfunction in patients with hidradenitis suppurativa

et al. 2022

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition associated with significant psychosocial comorbidity. To date, the relationship between HS and sexual dysfunction has not been assessed through meta‐analysis. A systematic review was performed by OVID Medline, EMBASE, Cochrane Central, PsycINFO via EBSCO, Web of Science, and LILACS. Original English language studies assessing HS and sexual function published prior to April 2020 were screened. Scores from the Female Sexual Function Index (FSFI), International Index of Erectile Function (IIEF), Arizona Sexual Experiences Scale (ASEX), Frankfurt Self‐Concept Scale for Sexuality (FKKS SEX), and Dermatology Life Quality Index (DLQI) were analyzed. Sixteen studies met inclusion criteria, and nine were eligible for meta‐analysis. Pooled mean FSFI score for female HS patients met criteria for sexual dysfunction (mean = 20.32, P < 0.001). Females with HS reported worse FSFI scores than controls (pooled mean difference = −5.704, P = 0.003, I2=0). Mean IIEF score among males with HS was 47.96 (P < 0.001). Males with HS also reported worse IIEF scores than controls (pooled mean difference = −18.77, P = 0.00, I2 = 0). Females with HS performed worse on sexual function inventories than males with HS (SMD = −0.72, P = 0.009, I2 = 0). Both male and female HS patients reported significantly more sexual impairment than same‐sex controls. Female HS patients also experience more sexual impairment than males and on average meet criteria for sexual dysfunction (FSFI <26.55). Clinicians should be aware that their patients with HS, especially females, may be suffering from sexual dysfunction and treated them appropriately.

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Acne Clinic: Morphogenesis

Cited by 9 publications

References 68 publications

A 1‐min double embedding method for small tissue specimens preserves comedone histology and eliminates the need for punch biopsies

A 1‐min double embedding method for small tissue specimens preserves comedone histology and eliminates the need for punch biopsies

Adult dermatology patients quality of life and acne vulgaris

A systematic review and meta‐analysis of sexual dysfunction in patients with hidradenitis suppurativa

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