Acne and Lipid Pathways

Zouboulis, Christos C.; Jourdan, Éric; Picardo, Mauro

doi:10.1007/978-3-319-09943-9_23

Cited by 3 publications

(3 citation statements)

References 80 publications

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“…This study was showed most age of AV cases, was (15-30) years. The gender distribution of the studied groups was 45 patients with Acne volgaris, 25 (56.00%) male and 20 (44.00%) female, the results represented in figure (1).There was no significant difference in age (P=0.71) and BMI (P=0.56) between patients and control,The mean ± SD of Survivin levels for AV patients and control (243.13 ± 75.29, 173.03 ± 87.62 ng/L) respectively and P-value (0.000) as showed in table (1) & figure (2), and The mean ± SD of Foxo1 levels for AV patients and control (4.74± 3.4, 2.37 ± 1.57 ng /ml) respectively , P-value 0.001 as showed in table (1) & figure (3), The results show significant difference in level of survivin between male and female but no significant difference in level of Foxo1 between this subgroup, as shown in Table (2) The results show no significant difference in level of survivin, and Foxo1 between Mild&Sever, as shown in Table (3) & figure (4). The results show no significant difference in level of survivin, and Foxo1 between BMI subgroup, as shown in Table (…”

Section: Resultsmentioning

confidence: 71%

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Assessment the role of survivin and FOXO1 in patient with acne vulgaris in Babylon City

Mahmoud

Juda

Salman

2022

ijhs

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Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production,occurs most prominently at skin sites with a high density of sebaceous glands such as the face,chest, and back. Survivin is an evolutionarily conserved eukaryotic protein that is essential for cell division , can inhibit cell death, Normally it is only expressed in actively proliferating cells. Survivin has been found to be increased in keratinocyte proliferative and inflammatory states, which are deeply involved in the pathogenesis of the acne lesions.Foxo1 is considered to be a representative member of the FoxO family, and has key transcription regulatory activities FoxOs are homeostatic factors in healthy skin and in skin disorders,Foxo1 a master regulatory factor for gluconeogenesis and glycogenolysis, as well as a positive regulator of the expression of insulin, is part of signaling axes related to the control of epidermal morphogenesis and the pathogenesis of acne ,The study was a case –control design which conducted in dermatology Al-Musayyab General Hospital and Al Imam Sadiq Hospital,Murjan Teaching Hospital. with 45 patients with Acne volgaris and 45 healthy controls, the level of serum survivin and Foxo1 were measured using an enzyme-linked immunosorbent assay (ELISA).

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Section: Resultsmentioning

confidence: 71%

“…However, changes in sebaceous gland activity not only correlate with seborrhea but also with alterations in sebum fatty acid composition. [4]. As increased value is put on appearance, adolescents with acne may have a low quality of life with regard to their emotional state.…”

Section: Introductionmentioning

confidence: 99%

Assessment the role of survivin and FOXO1 in patient with acne vulgaris in Babylon City

Mahmoud

Juda

Salman

2022

ijhs

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“…These cells have pattern recognition receptors (PRRs) which can recognize a large variety of pathogenic organism, that are responded to particular pathogen -associated molecular patterns (PAMPs) and cause activation of the innate immune system. The most important group of PRRs is Toll-like receptors (TLR-2) (4) ,that expressed in human sebocytes and keratinocytes, TLR-2 is activated by P.acnes and can change the content of lipid in sebum, then activates several proinflammatory cytokine included in acne lesions (5) , like interleukins (IL-1β, IL-1α, IL-12 and IL-8), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) (6,7,8) .…”

Section: Introductionmentioning

confidence: 99%

Clinical and Immunological Evaluation of Isotretinoin in Patients with Acne Vulgaris

Shubber,

Al mukhtar,

Al-Shibly

2021

Indian Journal of Forensic Medicine & Toxicology

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Objective: To study the clinical and immunological influence of isotretinoin drug in the management of acne vulgaris by evaluation some immunological parameters which include ( IL-1β, IL-8, IFN-γ, TNF-α and TLR2).Methods: This study is a randomized clinical trial carried out in clinical dermatology in Merjan Teaching Hospital in Babylon from September-2018 to March -2019.The number of patients in the present study was 30,their age between (14-30 years), who were diagnosed by dermatologist to having moderate to severe acne and measured the immunological parameters (IL-8, IL-1β, IFN-γ, TNF-α) and ( TLR-2 ) before treatment, then treated with isotretinoin (20mg) once daily for thirty days, the response were evaluated clinically and immunologically after one month of therapy, by measure the concentration of proinflammatory cytokines (IL-8, IL-1β, IFN-γ, TNF-α) and ( TLR-2 ) by using enzyme-linked Immunosorbent assay (ELISA) technic.Results: Significant elevation in the serum levels ( p ≤ 0.001) of immunological parameter (TLR-2, IL-8, IL-1β, TNF-α, and IFN-γ) among acne patients were noted in comparison to the control.After one months of treatment the clinical response in group treated with isotretinoin was good, moderate and poor in 9 (60%), 6(40%), 0(0%) respectively, the immunological results showed that significant reduced ( p ≤ 0.001) in the serum levels of (IFN-γ, IL-8, IL-1β,TNF-α and TLR-2) of pretreatment in comparison to post treatment after one month of therapy. Conclusion:Significant elevation (p≤ 0.001) in the serum levels of (TLR-2,IL-8, IL-1β, TNF-α, and IFN-γ) among moderate to severe acne patients before treatment in comparison to control group. Clinically isotretinoin efficient in treatment of patients with acne after one month of therapy. Immunologically isotretinoin significant reducing (p≤ 0.001) serum levels of (TLR-2, IL-8, IL-1β, TNF-α and IFN-γ ) of pretreatment patients in comparison to post treatment after one month of therapy.

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Antimicrobial Activities of Some Indonesian Medicinal Plants against Propionibacterium acnes (ATCC 27853) and Staphylococcus epidermis (ATCC 12228) causing Acne

et al. 2019

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Secondary metabolites investigation of local plants, such as Psidium guajava L, Curcuma longa rhizome, Citrus hystrix and Lawsonia intracellularis shown that they have antibacterial activities against Propionibacterium acnes (ATCC 27853) and Staphylococcus epidermis (ATCC 12228) with chloramphenicol as antibiotic controlled. The phytoscreening method used to find out compounds in the plants and inhibition tests carried out by diffuse test with a concentration variation of 10, 5, 2.5 and 1.25 %. It was found that Lawsonia intracellularis plants has the highest inhibitory growth of 17; 12, 15, 14, 12 mm at 10 % concentration.

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Acne and Lipid Pathways

Cited by 3 publications

References 80 publications

Assessment the role of survivin and FOXO1 in patient with acne vulgaris in Babylon City

Assessment the role of survivin and FOXO1 in patient with acne vulgaris in Babylon City

Clinical and Immunological Evaluation of Isotretinoin in Patients with Acne Vulgaris

Antimicrobial Activities of Some Indonesian Medicinal Plants against Propionibacterium acnes (ATCC 27853) and Staphylococcus epidermis (ATCC 12228) causing Acne

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