Acinetobacter baumannii — An emerging nosocomial pathogen in the burns unit Manipal, India

Sengupta, Shamik; Kumar, Pramod; Ciraj, AM; Pg, Shivananda

doi:10.1016/s0305-4179(00)00094-2

Cited by 37 publications

(22 citation statements)

References 11 publications

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“…15,16 But unfortunately the overuse, unjustified use, and missuse of the broad spectrum antibiotics may be responsible for spreading of infection resistant to those antibiotics and possibility of developing complications in future. 17 So, to prevent these multidrugs-resistant bacteria, regular updates of knowledge regarding the bacteriological review of pus culture and sensitivity is very much essential. 18 Hence, our aim in this study was to isolate the bacteria from pus and detection of its spectrum of antimicrobial sensitivity in our institution, which will definitely throw light of knowledge in the use of antibiotics in that type of organism.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Dhar¹,

Nandi²

2017

MGM Journal of Medical Sciences

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Increasing emergence of drug-resistant bacteria is becoming a major problem globally. A retrospective study of 790 culture and sensitivity reports on microbial isolates, from infected wounds was carried out in KPC Medical College and Hospital, Jadavpur, Kolkata, India. 504 patients were males and 286 females. Gram negative organisms were isolated in 561 and gram positive in 229. Among the gram negative organisms, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli were the most common, whereas Staph aureus was the only gram positive organism isolated. Antibiotic sensitivity tests revealed most gram negative organisms susceptible to carbapenems, polymyxin and colistin. Staphylococci showed sensitivity to tigecycline, clindamycin, vancomycin, teicoplanin and linezolid. Interesting differences in the type of organisms isolated in male and female patients were noted. For example Enterococcus faecalis was found only in female patients. Increasing resistance of microorganisms cultured from infected wounds to first line and even second line antibiotics is a matter of great concern and can be attributed to indiscriminate and irrational use of broad spectrum antibiotics. This has to stop forthwith if we want to prevent resistance to antibiotics; otherwise morbidity, mortality and health care costs in treating patients with wound infections are going to increase exponentially

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Section: Introductionmentioning

confidence: 99%

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Dhar¹,

Nandi²

2017

MGM Journal of Medical Sciences

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“…This opportunistic pathogen causes a variety of hospital-acquired infections, including pneumonia, urinary tract infections, bacteremia, and meningitis, especially in immunocompromised patients (for a review, see reference 6). Hospital outbreaks due to multidrug-resistant (MDR) A. baumannii strains have become increasingly common in hospitals worldwide and especially in intensive care units (17,18,51) and burn units (6,10,37,52,56,58). These multidrug-resistant strains are frequently resistant to the usual drug families such as aminoglycosides, fluoroquinolones, and ␤-lactams (penicillins and cephalosporins), although carbapenems remain the most used antimicrobial drugs.…”

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confidence: 99%

Channel Formation by CarO, the Carbapenem Resistance-Associated Outer Membrane Protein of Acinetobacter baumannii

Siroy

Molle

Lemaître‐Guillier³

et al. 2005

Antimicrob Agents Chemother

113

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It has been recently shown that resistance to both imipenem and meropenem in multidrug-resistant clinical strains of Acinetobacter baumannii is associated with the loss of a heat-modifiable 25/29-kDa outer membrane protein, called CarO. This study aimed to investigate the channel-forming properties of CarO. Mass spectrometry analyses of this protein band detected another 25-kDa protein (called Omp25), together with CarO. Both proteins presented similar physicochemical parameters (M w and pI). We overproduced and purified the two polypeptides as His-tagged recombinant proteins. Circular dichroism analyses demonstrated that the secondary structure of these proteins was mainly a ␤-strand conformation with spectra typical of porins. We studied the channel-forming properties of proteins by reconstitution into artificial lipid bilayers. In these conditions, CarO induced ion channels with a conductance value of 110 pS in 1 M KCl, whereas the Omp25 protein did not form any channels, despite its suggested porin function. The pores formed by CarO showed a slight cationic selectivity and no voltage closure. No specific imipenem binding site was found in CarO, and this protein would rather form unspecific monomeric channels.

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“…Ganapathy et al [26] have reported a 58% survival rate after the administration of colistin in MDR gram-negative infections in their burn centre. Trottier et al [27] have observed a 37 -87% resistance to imipenem, toramycin, amikacin and minocycline in patients with A.baumannii infections in their burn centre where all the cases were sensitive to colistin.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Burn Infections Caused by Multidrug Resistant A.baumannii and the Treatment Approach

Selcuk

2011

J Curr Surg

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Background: If not treated properly, A.baumannii infections in burn patients may cause delays in wound healing, graft losses, or even development of sepsis that may lead to death in cases where the bacteria enters the systemic circulation. In this study, our aim is to present the treatment options and their results in patients where burn infections due to multidrug resistant (MDR) A.baumannii have been diagnosed.

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Acinetobacter baumannii — An emerging nosocomial pathogen in the burns unit Manipal, India

Cited by 37 publications

References 11 publications

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Spectrum of Microbial Isolates from Wound Infections in Patients admitted in a Tertiary Care Hospital, Kolkata

Channel Formation by CarO, the Carbapenem Resistance-Associated Outer Membrane Protein of Acinetobacter baumannii

An Evaluation of Burn Infections Caused by Multidrug Resistant A.baumannii and the Treatment Approach

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