Acinetobacter baumannii: a universal threat to public health?

Giamarellou, Helen; Antoniadou, Anastasia; Kanellakopoulou, Kyriaki

doi:10.1016/j.ijantimicag.2008.02.013

Cited by 193 publications

(165 citation statements)

References 144 publications

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“…Along with CO, TIG appears to be the most potent agent in vitro against A. baumannii. 1,20 In a study from Greece, all of the MDR-A. baumannii strains isolated from ICU patients were found to be susceptible to TIG, including CO-resistant isolates.…”

Section: Discussionmentioning

confidence: 99%

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

et al. 2009

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The emergence of extensive drug-resistant (XDR) Acinetobacter baumannii limits the therapeutic options and leads to high mortality in intensive care units. Combined antibiotic therapy is frequently recommended for the treatment of these infections. Colistin (CO) and tigecycline (TIG), alone or in combination with other antimicrobials, are the most commonly used antibiotics in the treatment of these resistant infections. In this study, the in vitro synergistic activity of TIG and CO were tested for 25 XDR-A. baumannii strains isolated from ventilator-associated pneumonia by the Etest method. Resistance to CO was not detected, whereas 8% of the strains were resistant to TIG. The TIG-CO combination was more synergistic than TIG-rifampin and CO-rifampin according to the fractional inhibitory concentration index. No antagonism was detected between the drugs in the study. There was no strong correlation between the activity of the combinations with reference to strains or genotypes. Our results suggest that the combined use of TIG and CO may be useful for the treatment of XDR-A. baumannii infections.

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Section: Discussionmentioning

confidence: 99%

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

et al. 2009

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“…1,2 Patients are often hospitalised with severe illnesses when they are exposed to multidrug-resistant A. baumannii, an opportunistic pathogen, which has become more prevalent in the past 20 years. 3,4 Acinetobacter spp. possesses mechanisms of resistance to all existing antibiotic classes, as well as a great propensity for developing mechanisms of drug resistance rapidly.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of carbapenem resistance genes inAcinetobacter baumanniiisolated from clinical specimens obtained from an academic hospital in South Africa

Kock

Bellomo

Storm

et al. 2013

Southern African Journal of Epidemiology and Infection

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Original Research: Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens Acinetobacter baumannii is an important cause of hospital-acquired infections. The occurrence of carbapenem resistance that is caused by the carbapenem-hydrolysing class D β-lactamases and the metallo-β-lactamases (MBLs) limits the range of therapeutic alternatives in treating A. baumannii infections. In this study, two multiplex polymerase chain reactions were performed to screen for both carbapenem-hydrolysing class D β-lactamases and MBL genes in 97 clinical isolates of A. baumannii. Oxacillinase (OXA)-51 had a prevalence of 83% (81/97), and OXA-23 had a prevalence of 59% (57/97). One isolate was positive for an MBL [Verona integron-encoded metallo β-lactamases (VIM)]. Therefore, continuous surveillance and monitoring of A. baumannii is crucial because of the high prevalence of antibiotic resistance genes.Peer reviewed.

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“…[4][5][6][7] This microorganism can cause many infections such as sepsis, urinary tract infections, wound infections, ventilatory associated pneumonia, meningitis, and endocarditis and these infections have been strongly associated with increased morbidity and mortality. [8][9][10][11] Increasing resistance to broad-spectrum antibiotics including carbapenems has been reported. [12][13][14] Multidrug resistance is associated with high morbidity and mortality.…”

mentioning

confidence: 99%

Multidrug Resistance Among A. baumannii Isolates from Intensive Care Unit: A Four Years Retrospective Study

Doruk¹,

Köseoğlu²,

Yenişehirli³

et al. 2016

Turkiye Klinikleri Arch Lung

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Acinetobacter baumannii: a universal threat to public health?

Cited by 193 publications

References 144 publications

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

Prevalence of carbapenem resistance genes inAcinetobacter baumanniiisolated from clinical specimens obtained from an academic hospital in South Africa

Multidrug Resistance Among A. baumannii Isolates from Intensive Care Unit: A Four Years Retrospective Study

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