Multidrug Resistance Among A. baumannii Isolates from Intensive Care Unit: A Four Years Retrospective Study

Doruk, Sibel; Köseoğlu, Handan İnönü; Yenişehirli, Gülgün; Etikán, Ílker; Sağlam, Dursun Ali; Yılmaz, Ayşe; Kaya, Süheyla Uzun; Günal, Özgür

doi:10.5336/archlung.2015-49146

Cited by 4 publications

(4 citation statements)

References 22 publications

(26 reference statements)

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“…Tigecyclin and colistin resistance are still found low in Acinetobacter strains. In the study by Doruk et al, only two nosocomial infection-causing Acinetobacter strains were found to be resistant to tigecycline, while one was resistant to colistin 21 .…”

Section: Discussionmentioning

confidence: 96%

Acinetobacter-Associated nosocomial infections in Cumhuriyet University Medical Faculty Research Hospital; Three years’ experience

Engin¹

2017

Cumhuriyet Medical Journal

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Nosocomial infections have high mortality and morbidity. Acinetobacter is a Gram-negative bacilli and an important nosocomial pathogen. The number of nosocomial infections caused by antibiotic resistant-Acinetobacter strains has increased in recent years. Monitoring these bacterial infections which are difficult to treat, and antibiotic susceptibility, is very important for the appropriate treatment of patients. In this study, nosocomial infections caused by Acinetobacter in the hospital of Cumhuriyet University Medical Faculty during 2014-2016 were investigated. Method: Acinetobacter-associated nosocomial infections and their rate of antibiotic resistance in patients hospitalizing in the Cumhuriyet University Medical Faculty Research Hospital between January 2014 and December 2016 were retrospectively investigated. The data of this study are the surveillance data of the infection control committee and were obtained from the 3 years data registered in the infline software. Results: The rate of infection was 3.81% in the hospital, however, it was 30.86% in the Anesthesiology intensive care unit (ICU). In 2016, the rate of infection was lower in the hospital, whereas, it was higher in the Anesthesiology ICU. The number of Acinetobacter strains as a causative agent in the nosocomial infections were higher in 2016, too. In 7.16% of the nosocomial infections, Acinetobacter species were detected as the causative agent; Acinetobacter baumannii constituting 94.5%. Only two cases of colistin resistance were seen. Tigecycline resistance was detected in one strain. Meropenem and imipenem resistance were 91.1% and 93.8% for A. baumannii, respectively. Ventilator-associated pneumonia was the most common nosocomial infection due to Acinetobacter baumannii. Conclusions: Acinetobacter strains are among the most important nosocomial pathogens in our hospital. At the same time, the antibiotic resistance is increasing among Acinetobacter strains. Regular monitoring of these bacterial infections and in vitro susceptibility profiles of them is necessary to ensure an appropriate empirical treatment of Acinetobactermediated nosocomial infections.

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Section: Discussionmentioning

confidence: 96%

Acinetobacter-Associated nosocomial infections in Cumhuriyet University Medical Faculty Research Hospital; Three years’ experience

Engin¹

2017

Cumhuriyet Medical Journal

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“…[1] Extended hospital stays of patients followed in ICUs, invasive procedures, use of broad-spectrum antibiotics, and previous operations have been reported as risk factors for the infection of this microorganism. [1][2][3] A. baumannii can frequently cause nosocomial infections due to the increase in the number of patients followed in ICUs and can remain alive for a long time in the hospital environment due to their resistance to external environmental conditions. [4,5] The fact that A. baumannii strains are naturally resistant to many antibiotics and can develop resistance quickly can be a severe problem by limiting the antimicrobials to be used in the treatment against this infection, which can cause severe mortality.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics, Antibiotic Resistance Profiles, and Factors Affecting Mortality in Patients Isolated Acinetobacter Baumannii in Intensive Care Unit: Retrospective Tertiary Center Analysis

Arslan

2024

Comprehensive Med

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Objective: Acinetobacter baumannii is an important opportunistic pathogen that can cause severe septicemia and mortality. This study aims to investigate the antibiotic resistance profiles of patients isolated from A. baumannii in the intensive care unit (ICU) and the factors affecting mortality.Materials and Methods: Patients who were followed up in a tertiary ICU between January 2020 and January 2023 and who were found to have A. baumannii in various clinical samples were included in the study. The patients were divided into the mortality group (Group M) and the survival group (Group S). Their clinical features, antibiotic resistance profiles, and mortality factors were analyzed.Results: A total of 228 patients, 110 (48.2%) in Group M and 118 (51.8%) in Group S, were included in the study. The median age of the entire population was 67.5 (18-96), and 60.1% were male. A. baumannii strains were most commonly (59.2%) isolated from tracheal aspirate and sputum cultures. Resistance to carbapenems was 94.2-96.8%, aminoglycosides 88.5-99.2%, tigecycline 54.6%, and colistin 8.1%. Group M had significantly higher Acute Physiology and Chronic Health Evaluation-2 (APACHE-2) scores, mechanical ventilation requirements, and multidrug-resistant A. baumannii count. Independent risk factors for mortality were determined by APACHE-2 scores and mechanical ventilator application at the time of admission to the ICU. Conclusion:We think that in A. baumannii infections, which are highly resistant to many antibiotics and have high mortality rates, determining the risk factors indicating mortality and antibiotic resistance profiles and making treatment plans will contribute to the prognosis of the patients.

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“…Acinetobacter baumannii özellikle yoğun bakım ünitesinde (YBÜ) yatan hastalarda pnömoni, üriner sistem enfeksiyonu, menenjit, yumuşak doku enfeksiyonu ve bakteriyemi gibi birçok enfeksiyona neden olabilen önemli bir fırsatçı patojendir (1,3). Uzun süre hastanede yatış, geniş spektrumlu antibiyotik kullanımı ve mekanik ventilatör ya da kateter gibi invaziv işlemlerin uygulanması A.baumannii'ye bağlı enfeksiyonların oluşmasında risk faktörleri arasında sayılabilir (4,5). İleri medikal destek gereken hastaların sayısının artması bu enfeksiyonların insidansının artmasına neden olmuştur (5).…”

Section: Introductionunclassified

“…Uzun süre hastanede yatış, geniş spektrumlu antibiyotik kullanımı ve mekanik ventilatör ya da kateter gibi invaziv işlemlerin uygulanması A.baumannii'ye bağlı enfeksiyonların oluşmasında risk faktörleri arasında sayılabilir (4,5). İleri medikal destek gereken hastaların sayısının artması bu enfeksiyonların insidansının artmasına neden olmuştur (5). A.baumannii suşlarının birçok antibiyotiğe doğal dirençli olmaları ve kısa sürede kazanılmış direnç geliştirebilmeleri, tüm dünyada tedavi politikalarında ciddi problemler oluşturmakta, ayrıca hastanede yatış süresinin uzaması, tedavi maliyetleri ve mortalitenin artması gibi pek çok sorunu da beraberinde getirmektedir (6,7,8).…”

Section: Introductionunclassified

Yoğun Bakım Ünitelerinden İzole Edilen Acinetobacter Baumannıı Suşlarının Direnç Profili: Beş Yıllık Çalışma

DURAN¹,

CEKEN²,

Atik³

2021

Mustafa Kemal Üniversitesi Tıp Dergisi

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Amaç: Antibiyotik direnci son yıllarda tüm dünyada artış göstermiştir. Bu durum özellikle yoğun bakım ünitelerinde (YBÜ) yatan hastalarda ciddi sağlık problemi oluşturmaktadır. Acinetobacter baumannii YBÜ’de yatan hastalarda çoklu ilaç dirençli enfeksiyonların önemli bir nedeni haline gelmiştir. Bu çalışmanın amacı YBÜ’den izole edilen A.baumannii suşlarının direnç oranlarını saptamaktır. Gereç ve Yöntem:2015-2019 yılları arasında YBÜ’lerden mikrobiyoloji laboratuvarına gönderilen çeşitli örneklerden izole edilen A.baumannii suşları çalışmaya dahil edilmiştir. Bakteri tanımlaması ve antibiyotik duyarlılık testleri konvansiyonel yöntemler ve otomatize sistemler kullanılarak yapılmıştır. Bulgular: Toplam 773 A.baumannii suşu çalışmaya dahil edilmiştir. Suşların izole edildiği örnekler arasında endotrakeal aspirat örnekleri ilk sırada (%65.3) saptanmıştır. İzole edilen A.baumannii suşlarının en dirençli olduğu antibiyotik grubu karbapenemler (%96.5) olarak bulunmuştur. Siprofloksasine %96.1, netilmisine %89.8, gentamisine %88, amikasine %66 ve trimetoprim-sülfametoksazole %67.7 direnç tespit edilmiştir. Ayrıca, direnç oranlarının yıllar içinde arttığı gözlenmiştir. Sonuç: A.baumannii suşlarının antimikrobiyal ajanlara direnç oranları hastaneler arasında farklılık gösterdiğinden her hastane belirli aralıklarla kendi antibiyotik direnç profilini gözden geçirmeli ve antibiyotik kullanım politikalarını belirlemelidir. Ayrıca geniş spektrumlu antibiyotiklerin yaygın kullanımının kısıtlanarak direnç gelişiminin önlenmesi hedeflenmelidir.

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Multidrug Resistance Among A. baumannii Isolates from Intensive Care Unit: A Four Years Retrospective Study

Cited by 4 publications

References 22 publications

Acinetobacter-Associated nosocomial infections in Cumhuriyet University Medical Faculty Research Hospital; Three years’ experience

Acinetobacter-Associated nosocomial infections in Cumhuriyet University Medical Faculty Research Hospital; Three years’ experience

Clinical Characteristics, Antibiotic Resistance Profiles, and Factors Affecting Mortality in Patients Isolated Acinetobacter Baumannii in Intensive Care Unit: Retrospective Tertiary Center Analysis

Yoğun Bakım Ünitelerinden İzole Edilen Acinetobacter Baumannıı Suşlarının Direnç Profili: Beş Yıllık Çalışma

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