Acinetobacter bacteraemia in a teaching hospital, 1989–1998

Valero, Carmen; Palomo, J. D. García; Matorras, P; Fernández-Mazarrasa, Carlos; Fernández, Camino; Fariñas, M C

doi:10.1016/s0953-6205(01)00150-9

Cited by 21 publications

(18 citation statements)

References 22 publications

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“…Appropriate empirical antibiotics use was defined as treatment with at least one antibiotic that had in vitro activity against the pathogen and administered at the onset of A. baumannii bacteremia, with correct dosage, and with the use of at least 48 hours; otherwise, the empirical antibiotic treatment was defined as inappropriate (30). Death of a patient was considered directly related to the bacteremia if it occurred during the phase of active infection, with no evidence of another cause (31).…”

Section: Terminologymentioning

confidence: 99%

Prediction of Patient Outcome from Acinetobacter baumannii Bacteremia with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II Scores

et al. 2011

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Objective Acinetobacter baumannii is an important nosocomial pathogen associated with a high mortality rate. However, no objective and quantitative severity scores are available for the severity stratification. We aimed to assess the effectiveness of SOFA and APACHE II scores calculated at the onset of bacteremia in predicting the mortality of patients with A. baumannii bacteraemia. Patients and Methods A total of 110 patients with A. baumannii bacteremia were included in this retrospective study during the 40-month study period. Information including clinical and laboratory data was collected. Results Multivariate analysis showed that both SOFA and APACHE II scores were independent outcome predictors after adjustment for other parameters. Goodness-of-fit was good for SOFA and APACHE II, and both models displayed excellent AUROCs (SOFA: 0.83 ± 0.06, APACHE II: 0.82 ± 0.08 in predicting 14-day mortality; SOFA: 0.85 ± 0.04, APACHE II: 0.81 ± 0.04 in predicting in-hospital mortality). There was no significant difference in the predictions of the two scoring systems, and the scores were highly correlated (r 2 =0.724, p <0.001). We found that SOFA >8, APACHE II >29 and SOFA >7, APACHE II >23 are associated with significantly higher 14-day and in-hospital mortality rates, respectively. Conclusion SOFA and APACHE II scores assessed at the onset of bacteremia are reliable risk stratifying tools in predicting 14-day and in-hospital mortality in A. baumannii bacteremia. For ease of calculation, the use of SOFA rather than APACHE II score to predict mortality of A. baumannii bacteremia might have clinical application.

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Section: Terminologymentioning

confidence: 99%

Prediction of Patient Outcome from Acinetobacter baumannii Bacteremia with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II Scores

et al. 2011

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“…Sepsis and/or septic shock has been reported in 19% of patients with Acinetobacter bacteraemia, highlighting the true pathogenicity of several strains [93]. However, from cases with bacteraemia Acinetobacter spp.…”

Section: The Clinical Impact Of Acinetobacter Infectionsmentioning

confidence: 99%

“…A high rate of non-A. baumannii isolates has been implicated in bacteraemic patients with haematological malignancies, while most A. baumannii bacteraemic isolates are derived from ICU patients [93].…”

Section: The Clinical Impact Of Acinetobacter Infectionsmentioning

confidence: 99%

Acinetobacter baumannii: a universal threat to public health?

Giamarellou

Antoniadou

Kanellakopoulou

2008

International Journal of Antimicrobial Agents

195

136

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“…Environmental contamination of various hospital items has often been identified, ranging from suctioning equipment to pillows and mattresses (13). Foreign bodies such as catheters play an important role in the pathogenic occurrence of A. lwoffi bacteremia (40,43). Hand organism carriage by health care workers has been implicated in outbreaks of Acinetobacter infections (2).…”

Section: Vol 46 2008mentioning

confidence: 99%

Acinetobacter septicus sp. nov. Association with a Nosocomial Outbreak of Bacteremia in a Neonatal Intensive Care Unit

Kılıç¹,

Li²,

Mellmann³

et al. 2008

J Clin Microbiol

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Acinetobacter species other than Acinetobacter baumannii have rarely been reported to be associated with nosocomial outbreaks of bloodstream infections. Within a period of 1 week, seven Acinetobacter-like isolates were recovered from peripheral blood and catheter specimens of five patients at a neonatal intensive care unit (NICU) in a tertiary hospital in Turkey. All five patients had placement of central venous catheters and had received total parenteral nutrition before the onset of bacteremia. Two of the five patients died. Medical devices, tap water, aerators, water samples, various surfaces, intravenous fluids, and the hands of health care workers in the NICU were sampled and were culture negative for the bacterium. All seven of the isolates had identical biochemical reactions, antimicrobial susceptibility results, and pulsed-field gel electrophoresis patterns, indicating a clonal nosocomial outbreak. A panel of standard biochemical reaction profiles and three phenotypic commercial identification systems failed to identify these isolates. Phenotypically, the isolate differed from Acinetobacter ursingii by its hemolysis on sheep blood agar and its negative citrate utilization. Sequences of the full 16S rRNA gene, which contained at least three different gene copies with polymorphic sequences between nucleotide positions 70 and 206, were determined from the first recovered isolate. The complete 1,529-to 1,531-bp 16S rRNA gene sequences and partial 801-bp rpoB gene sequences had similarities of 99.5% and 97.2%, respectively, to an A. ursingii isolate. The DNA-DNA similarities of the strain against the type strain of A. ursingii were 64.7 and 68.7%, which were lower than the recommended threshold value of 70% for the definition of bacterial species. These data indicate that a novel Acinetobacter organism caused the nosocomial outbreak of bacteremia in the NICU unit. We propose the designation of Acinetobacter septicus sp. nov. for these isolates, with isolate AK001 as the type strain.

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Acinetobacter bacteraemia in a teaching hospital, 1989–1998

Cited by 21 publications

References 22 publications

Prediction of Patient Outcome from Acinetobacter baumannii Bacteremia with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II Scores

Prediction of Patient Outcome from Acinetobacter baumannii Bacteremia with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II Scores

Acinetobacter baumannii: a universal threat to public health?

Acinetobacter septicus sp. nov. Association with a Nosocomial Outbreak of Bacteremia in a Neonatal Intensive Care Unit

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