Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation

Afzali, Hamideh; Khaksari, Mohammad; Norouzirad, Reza; Jeddi, Sajad; Kashfi, Khosrow; Ghasemi, Asghar

doi:10.1016/j.niox.2020.07.001

Cited by 15 publications

(18 citation statements)

References 43 publications

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“…The cytology test results found that the UPH was able to significantly increase the secretion of NO in RAW264.7 cells, which indicated that UPH could regulate inflammation in vitro. Furthermore, NO can regulate inflammation and stimulate angiogenesis and cell proliferation [ 25 ]. Inflammatory factors play an important role in the wound healing process.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application as Wound Healing Dressing

Liu

Geng

et al. 2022

Molecules

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Nowadays, natural polysaccharides-based hydrogels have achieved promising results as dressings to promote skin healing. In the present study, we prepared a novel hydrogel nanocomposite with poly(vinyl alcohol) (PVA) and sulfated heterosaccharide (UF), named UPH. The SEM results showed that the UPH had dense porous structures with a high porosity and a specific surface area. The UPH had a good swelling property, which can effectively adsorb exudate and keep the wound moist. The in vitro experiments results showed that the UPH was non-cytotoxic and could regulate the inflammatory response and promote the migration of fibroblasts significantly. The phenotypic, histochemistry, and Western blot analyses showed UPH treatment accelerated the wound healing and recovery of skin tissue at wound sites in a C57BL/6 mouse model. Furthermore, the UPH could promote the inflammation process to onset earlier and last shorter than that in a normal process. Given its migration-promoting ability and physicochemical properties, the UPH may provide an effective application for the treatment and management of skin wounds.

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Section: Discussionmentioning

confidence: 99%

Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application as Wound Healing Dressing

Liu

Geng

et al. 2022

Molecules

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“…[ 306 ] However, decreased NO bioavailability in Type‐II diabetes contributes to impaired wound healing. [ 307 ] Therefore, the delivery of NO to the wound sites of diabetic patients is anticipated. Indeed, NO exhibits perfect antibacterial property.…”

Section: Nanomaterials For Treatment Of Diabetes Complicationsmentioning

confidence: 99%

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

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Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

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“…A recent study found that acidified nitrite improved wound healing in rats with diabetes. 75 Dietary inorganic nitrate NO may also be produced from dietary inorganic nitrate, as is present in high concentrations in green leafy and some root vegetables, e.g. spinach, lettuce, rocket, beetroot, celery, fennel, radish and Chinese cabbage.…”

Section: Organic Nitratesmentioning

confidence: 99%

“…Under Therapeutic inorganic nitrite and nitrate, please consider adding the use of nitrite/nitrate in animal models of wound healing. Refer to Afzali et al 2020 2 for an introduction to this.…”

Section: Data Availabilitymentioning

confidence: 99%

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Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

et al. 2021

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Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largely mediated by high local NO concentrations produced by cellular inducible nitric oxide synthase, and by derivative reactive nitrogen oxide species including peroxynitrite and S-nitrosothiols. NO may be taken as dietary substrate (inorganic nitrate, L-arginine), and therapeutically as gaseous NO, and transdermal, sublingual, oral, intranasal and intravenous nitrite or nitrate. Numerous preclinical studies have demonstrated that NO has generic static and cidal activities against viruses (including β-coronaviruses such as SARS-CoV-2), bacteria, protozoa and fungi/yeasts in vitro. Therapeutic effects have been seen in animal models in vivo, and phase II trials have demonstrated that NO donors can reduce microbial infection. Nevertheless, excess NO, as occurs in septic shock, is associated with increased morbidity and mortality. In view of the dose-dependent positive and negative effects of NO, safety and efficacy trials of NO and its donors are needed for assessing their role in the prevention and treatment of infections. Trials should test dietary inorganic nitrate for pre- or post-exposure prophylaxis and gaseous NO or oral, topical or intravenous nitrite and nitrate for treatment of mild-to-severe infections, including due to SARS-CoV-2 (COVID-19). This review summarises the evidence base from in vitro, in vivo and early phase clinical studies of NO activity in viral, bacterial, protozoal and fungal infections.

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Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation

Cited by 15 publications

References 43 publications

Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application as Wound Healing Dressing

Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application as Wound Healing Dressing

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

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