Acid Phosphatase Activity in Human Breast Tumors

Abstract

We examined lysosomal participation in the degradation of tumor cells from human breast biopsies, utilizing the histochemical activity and localization of acid phosphatase (AP). Enzyme activities in benign and malignant lesions were compared. AP was faintly detected in normal mammary epithelia and was marked in malignant cells. The histochemical patterns of AP distribution in the breast tissues showed differences between normal and neoplastic cells. AP staining was more intense in ductal carcinoma in situ (DCIS) associated with invasive ductal carcinoma (IDC) cases compared to when IDC was present alone. These results suggest that non-invasive breast cancers, such as DCIS, may be subjected to more lysosomal cellular lysis than is observed in invasive breast cancers, like IDC. Keywords acid phosphatase, lysosomes, breast cancer, ductal carcinoma in situ, invasive ductal carcinoma

Effect of Aqueous Extract of Selected Plants on Liver, Bone and Kidney Markers of 7,12-Dimethylbenz(A)Anthracene (DMBA) Treated Albino-Rats

“…There was noteworthy decrease (p≤0.05) in animals treated with the standard drug when juxtaposed with the DMBA un-treated animal and the control; other groups demonstrated no huge difference (p≤0.05). Acid phosphatase (AP) is a marker of prostate growth [28] and of metastatic bone malady in patients with cancer of the breast [29]. Normal serum range of acid phosphatase is 2.5 to 3.7ng/ml.…”

Modulation of Acid Phosphatase and Lactic Dehydrogenase in Hexachlorocyclohexane‐Induced Hepatocarcinogenesis in Mice

“…The dissolution of such proteins by acid hydrolases of the lysosomes appears to be the heart of metastasis . Acid phosphatase (ACP) is one of the hydrolytic enzymes used to monitor cell death and cell lysis .…”

“…The cadherins, cell adhesion molecules such as desmoglein and desmocollin, are proteins that hold the cells in their position in the tissue. The dissolution of such proteins by acid hydrolases of the lysosomes appears to be the heart of metastasis . Acid phosphatase (ACP) is one of the hydrolytic enzymes used to monitor cell death and cell lysis .…”