2019
DOI: 10.1016/j.micpath.2019.01.022
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Acid-happy: Survival and recovery of enteropathogenic Escherichia coli (EPEC) in simulated gastric fluid

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Cited by 30 publications
(30 citation statements)
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“…Benefited from the complicated AR and ATR systems, E. coli can survive without growth for several hours at pH 2.0 1,18-20 , and the acid limit for growth of E. coli is pH 4.0 in rich medium, or pH 4.5 in minimal medium 6,18,[20][21][22] . So, E. coli will experience the transition of pH from no-growth to growth conditions when passing through the stomach and entering the intestine.…”
mentioning
confidence: 99%
“…Benefited from the complicated AR and ATR systems, E. coli can survive without growth for several hours at pH 2.0 1,18-20 , and the acid limit for growth of E. coli is pH 4.0 in rich medium, or pH 4.5 in minimal medium 6,18,[20][21][22] . So, E. coli will experience the transition of pH from no-growth to growth conditions when passing through the stomach and entering the intestine.…”
mentioning
confidence: 99%
“…Upon ingestion of contaminated food or water, EPEC and EHEC initially enter the stomach. Acidity of the gastric fluid not only aids the host in digestion of food but also serves as a significant barrier to enteric infection (Pienaar, Singh, & Barnard, 2019;Yasutomi et al, 2018). EPEC has the ability to withstand and recover from exposure to simulated gastric fluid (Pienaar et al, 2019).…”
Section: The Physical Landscape and Ae Pathogensmentioning
confidence: 99%
“…Acidity of the gastric fluid not only aids the host in digestion of food but also serves as a significant barrier to enteric infection (Pienaar, Singh, & Barnard, 2019;Yasutomi et al, 2018). EPEC has the ability to withstand and recover from exposure to simulated gastric fluid (Pienaar et al, 2019). However, during EHEC infection, 20-80% of ingested bacteria are estimated to die before reaching the small intestine (Takumi, de Jonge, & Havelaar, 2000).…”
Section: The Physical Landscape and Ae Pathogensmentioning
confidence: 99%
“…Shifts in pH can also interfere with the proton motive force and change the protein profile of the outer membrane in Gram-negative cells. This can cause cells to fail to use proton pumps to remove H + ions from the cells (Pienaar et al, 2019). Acidification also disrupts key biochemical processes (Chung et al, 2006).…”
Section: Acid Stress Induction and Evaluation Of Cell Culture And Viamentioning
confidence: 99%
“…Oliver (2010) suggested that entering VBNC is a strategy of bacterial survival when environmental conditions are not suitable for normal growth. Although VBNC cells cannot be cultured, they can maintain metabolic activity and express toxic proteins (Ding et al, 2017), energy activity and respiratory activity (Pienaar et al, 2019), membrane integrity (Lahtinen et al, 2008), and main regulatory gene from the general stress response (Kusumoto et al, 2012). Pinto et al (2013) explained that cell populations that can be cultured when induced into VBNC conditions will experience a reduction in the number of cells that can be cultured to below the detection limit and other cell populations i.e.…”
Section: Acid Stress Induction and Evaluation Of Cell Culture And Viamentioning
confidence: 99%