Acid–base titration using a microfluidic thread-based analytical device (μTAD)

Jarujamrus, Purim; Prakobkij, Akarapong; Puchum, Sodsai; Chaisamdaeng, Sawida; Meelapsom, Rattapol; Anutrasakda, Wipark; Amatatongchai, Maliwan; Chairam, Sanoe; Citterio, Daniel

doi:10.1039/d0an00522c

Cited by 15 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, distance and barcode-based detection are another two possible low-cost detection strategies (Tan et al, 2021). Distance-based detection relies on the fact that disparate wetting performances can be induced by different analytes for identification (Alsaeed and Mansour, 2020;Jarujamrus et al, 2020;Shimazu et al, 2022). Moreover, barcode detection can provide results of multiple analyte reactions (e.g., blood typing) that otherwise are difficult to achieve (Nilghaz et al, 2014).…”

Section: Thread-based Analytical Devices(µtads)mentioning

confidence: 99%

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Mesquita

Gong

Lin

2022

Front. Lab. Chip. Technol.

View full text Add to dashboard Cite

Effective environmental monitoring has become a worldwide concern, requiring the development of novel tools to deal with pollution risks and manage natural resources. However, a majority of current assessment methods are still costly and labor-intensive. Thanks to the rapid advancements in microfluidic technology over the past few decades, great efforts have been made to develop miniaturized tools for rapid and efficient environmental monitoring. Compared to traditional large-scale devices, microfluidic approaches provide several advantages such as low sample and energy consumption, shortened analysis time and adaptabilities to onsite applications. More importantly, it provides a low-cost solution for onsite environmental assessment leveraging the ubiquitous materials such as paper and plastics, and cost-effective fabrication methods such as inkjet printing and drawing. At present, devices that are disposable, reproducible, and capable of mass production have been developed and manufactured for a wide spectrum of applications related to environmental monitoring. This review summarizes the recent advances of low-cost microfluidics in the field of environmental monitoring. Initially, common low-cost materials and fabrication technologies are introduced, providing a perspective on the currently available low-cost microfluidic manufacturing techniques. The latest applications towards effective environmental monitoring and assessment in water quality, air quality, soil nutrients, microorganisms, and other applications are then reviewed. Finally, current challenges on materials and fabrication technologies and research opportunities are discussed to inspire future innovations.

show abstract

Section: Thread-based Analytical Devices(µtads)mentioning

confidence: 99%

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Mesquita

Gong

Lin

2022

Front. Lab. Chip. Technol.

View full text Add to dashboard Cite

show abstract

“…The base processes of operation in the μTAD are driven by capillary action between the threads that drive the sample to the sites where reagents are immobilized so as to promote a reaction . These reagents can be designed to leverage detection techniques such as colorimetry, − which provides a qualitative signal to the eye or to a smartphone-based detection, which are further highlighted by the thread's white color. − Owing to their utility, μTADs have been used to perform a myriad of assays including glucose assays, enzyme-linked immune-sorbent assays (ELISA), immunochromatographic assays. − …”

Section: Introductionmentioning

confidence: 99%

Knitting Thread Devices: Detecting Candida albicans Using Napkins and Tampons

et al. 2021

View full text Add to dashboard Cite

Reproducible and in situ microbial detection, particularly of microbes significant in urinary tract infections (UTIs) such as Candida albicans, provides a unique opportunity to bring equity in the healthcare outcomes of disenfranchised groups like women in low-resource settings. Here, we demonstrate a system to potentially detect vulvovaginal candidiasis by leveraging the properties of multifilament cotton threads in the form of microfluidic-thread-based analytical devices (μTADs) to develop a frugal microbial identification assay. A facile mercerization method using heptane wash to boost reagent absorption and penetration is also performed and is shown to be robust compared to other existing conventional mercerization methods. Furthermore, the twisted mercerized fibers are drop-cast with media consisting of l-proline β-naphthylamide, which undergoes hydrolysis by the enzyme l-proline aminopeptidase secreted by C. albicans, hence signaling the presence of the pathogen via simple color change with a limit of detection of 0.58 × 106 cfu/mL. The flexible and easily disposable thread-based detection device when integrated with menstrual hygiene products showed a detection time of 10 min using spiked vaginal discharge. The developed method boasts a long shelf life and high stability, making it a discreet detection device for testing, which provides new vistas for self-testing multiple diseases that are considered taboo in certain societies.

show abstract

“…However, pH based titrimetric analyses indicate noting the titrimetric value of a titration at the turning point of the color change of the indicators. [51][52][53] Hence, based on this principle of pH-dependent color change, we have integrated thread substrate with a colorimetric microbial assay by employing the conventional metabolic sugar fermenting prole of microbes [54][55][56] (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

Thread integrated smart-phone imaging facilitates early turning point colorimetric assay for microbes

et al. 2020

View full text Add to dashboard Cite

show abstract

Acid–base titration using a microfluidic thread-based analytical device (μTAD)

Abstract: This work presents a novel analytical approach for precise and quick (within 2 minutes) determination of acid and base concentrations (of very small amount) by titration using a microfluidic thread-based analytical device (μTAD).

Cited by 15 publications

References 20 publications

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Knitting Thread Devices: Detecting Candida albicans Using Napkins and Tampons

Thread integrated smart-phone imaging facilitates early turning point colorimetric assay for microbes

Contact Info

Product

Resources

About