Acid-Base Catalysis of Chiral Pd Complexes: Development of Novel Catalytic Asymmetric Reactions and Their Application to Synthesis of Drug Candidates

Hamashima, Yoshitaka

doi:10.1248/cpb.54.1351

Cited by 16 publications

(2 citation statements)

References 63 publications

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“…In general, two approaches are utilized for this objective, asymmetric synthesis and chiral separation. Asymmetric synthesis using chiral sources, such as chiral pools, chiral auxiliaries, asymmetric catalysts, and enzymes, has significantly progressed over the last few decades. − Although the large-scale preparation of enantiomers can be economically attained using this approach, the products do not always show a high ee, and therefore, a further purification step may be inevitable. Additionally, nature produces only one of the enantiomers as a chiral source in most cases.…”

Section: Introductionmentioning

confidence: 99%

Structure Control of Polysaccharide Derivatives for Efficient Separation of Enantiomers by Chromatography

2009

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Section: Introductionmentioning

confidence: 99%

Structure Control of Polysaccharide Derivatives for Efficient Separation of Enantiomers by Chromatography

2009

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“…TTB and (-)-DRL-16126 (IS) were synthesized using the synthetic process reported by Hamashima (2006) and were characterized using chromatographic and spectral techniques (IR, UV, OR, HPLC, 1 H and 13 C NMR). Purity was found to be more than 99% for both the compounds.…”

Section: Experimental Chemicals and Reagentsmentioning

confidence: 99%

Development and validation of a sensitive LC‐MS/MS method with electrospray ionization using multiple ions for quantitation of torcetrapib in hamster and dog plasma

Trivedi¹,

Dubey²,

Mullangi³

et al. 2007

Biomedical Chromatography

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A highly sensitive and specific LC-MS/MS method has been developed and validated for the estimation of torcetrapib (TTB) with 100 microL hamster/dog plasma using DRL-16126 as an internal standard (IS). The API-4000 Q Trap LC-MS/MS was operated under multiple-reaction monitoring mode using the electrospray ionization technique. The assay procedure involved extraction of TTB and IS from plasma with acetonitrile, which yielded consistent recoveries of 65.73 and 94.01% for TTB and 79.68 and 90.70% for IS in hamster and dog plasma, respectively. The total chromatographic run time was 3.0 min and the elution of TTB and IS occurred at approximately 2.25 and 2.20 min, respectively. The resolution of peaks was achieved with 0.01 m ammonium acetate:acetonitrile (15:85, v/v) at a flow rate of 0.40 mL/min on an Inertsil ODS-3 column. The method was proved to be accurate and precise at linearity range of 1.00-200 ng/mL with a correlation coefficient (r) of > or = 0.993. The method was rugged with 1.00 ng/mL as the lower limit of quantitation. TTB was stable in the battery of stability studies. The application of the assay to preclinical pharmacokinetic studies confirmed the utility of the assay to derive hamster/dog pharmacokinetic parameters.

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Metal‐Catalyzed Enantio‐ and Diastereoselective C–C Bond‐Forming Reactions in Domino Processes

Takizawa

Sasai

2013

Domino Reactions

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Acid-Base Catalysis of Chiral Pd Complexes: Development of Novel Catalytic Asymmetric Reactions and Their Application to Synthesis of Drug Candidates

Cited by 16 publications

References 63 publications

Structure Control of Polysaccharide Derivatives for Efficient Separation of Enantiomers by Chromatography

Structure Control of Polysaccharide Derivatives for Efficient Separation of Enantiomers by Chromatography

Development and validation of a sensitive LC‐MS/MS method with electrospray ionization using multiple ions for quantitation of torcetrapib in hamster and dog plasma

Metal‐Catalyzed Enantio‐ and Diastereoselective C–C Bond‐Forming Reactions in Domino Processes

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