Acid-activated ROS generator with folic acid targeting for bacterial biofilm elimination

Debridement of contaminated implants using air-polishing coupled with pH-responsive maximin H5-embedded metal-organic frameworks

“…It is widely assumed that coordination between 2-methylimi-dazolate and zinc ions was acid-sensitive, ZIF-8 NPs were stable under neutral conditions but degrade rapidly in the acidic environment ( Yu et al, 2021 ). To demonstrate the potentials of MH5C@ZIF-8 NPs as a pH-responsive delivering nano-systems of antimicrobial peptide, the release study of MH5C was completed in both PBS buffer at pH 7.4 and MES buffer at pH 5.5.…”

“…Moreover, antibiofilm results quantitatively demonstrated that the biofilm destruction efficiencies were slightly decreased as MH5C encapsulated into the ZIF-8 crystals, partly due to the gradual degradation of ZIF-8 and the sustainedrelease of MH5C (Yu et al, 2021). The slow-release sterilization abilities were mainly associated with degradation of MOFs, further determined by the chemical stability and the structural characteristic of MOFs (Cao et al, 2020).…”

Antibacterial and antibiofilm mechanisms of carbon dots: a review

“…When the level of ROS increased, it can cause some irreversible damage to the bacterial cells, such as the destruction of cell membrane, mitochondrial membrane and other membrane structures, oxidative damage to proteins, lipids, etc., and the breakage of DNA strands. 23,[47][48][49][50][51][52][53][54][55] Gao et al synthesized novel carbon dots (CDs) by a one-pot hydrothermal method using ampicillin. 56 The CDs showed good antibacterial activity against S. aureus and L. monocytogenes even at low concentrations.…”

A novel quaternized carbon dot–papain complex for the double-target anti-biofilm activity and visualization-ratio fluorescence dual-mode detection of H2O2

“…11 Though antibacterial CDs have exhibited great potential in antibiofilm fields, the strategy and mechanism of the antibiofilm process are rarely reported. 12 To enhance the antibacterial and antibiofilm abilities of CDs, and to design and filter CDs with strong antibiofilm compatibility to reduce or even eradicate biofilm-cause infections, researchers are now working on the target and mechanism of the antibiofilm behavior of CDs. The targets of CDs against the biofilm generally involve two aspects, the host bacteria and their extracellular polymeric substance (EPS) in the biofilm.…”

“…11 Though antibacterial CDs have exhibited great potential in antibiofilm fields, the strategy and mechanism of the antibiofilm process are rarely reported. 12…”