A novel quaternized carbon dot–papain complex for the double-target anti-biofilm activity and visualization-ratio fluorescence dual-mode detection of H₂O₂

Abstract

Since biofilm infections could cause chronic diseases and drug resistance, posing serious threat to human health, the development of antibiofilm nanomaterials has attracted the interest of researchers. In this paper,...

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

“…The authors reported that CDs at medium concentrations inhibited biofilms, while at high concentrations they eradicated biofilms . Quaternized CD–papain complexes showed excellent inhibition of S. aureus biofilms at a minimum concentration of 20 μg/mL via mechanisms of membrane, DNA, and protein degradation and papain-based hydrolysis of proteins . Aminoguanidine CDs (AG/CA CDs) prepared by Otis et al in 2019 were reported to exhibit excellent bactericidal and anti-biofilm properties on P. aeruginosa .…”

“…102 Quaternized CD− papain complexes showed excellent inhibition of S. aureus biofilms at a minimum concentration of 20 μg/mL via mechanisms of membrane, DNA, and protein degradation and papain-based hydrolysis of proteins. 111 Aminoguanidine CDs (AG/CA CDs) prepared by Otis et al 113 in 2019 were reported to exhibit excellent bactericidal and anti-biofilm properties on P. aeruginosa. Their results revealed dosedependent inhibition of bacterial growth with complete inhibition of growth at 0.5 mg/mL AG/CA CD concentration.…”