Achyranthes bidentata polysaccharides activate the Wnt/β-catenin signaling pathway to promote chondrocyte proliferation

Weng, Xiaping; Lin, Pingdong; Liu, Fayuan; Chen, Jiashou; Li, Huiting; Huang, Lichan; Zhen, Chunsong; Xu, Huifeng; Liu, Xianxiang; Ye, Hongzhi; Li, Xihai

doi:10.3892/ijmm.2014.1869

Cited by 53 publications

(43 citation statements)

References 25 publications

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“…The present study showed that several mRNA (MMP-9, MMP-13, BMP-2 and ADAMTS5) are up-regulated and one mRNA (COL2A1) down-regulated in OA compared with normal cartilage. Our findings concerning expression of mRNA are consistent with those of previous studies of OA [27][28][29] . Thus, the present RT-PCR results supported cartilage degeneration in the OA group.…”

Section: Discussionsupporting

confidence: 93%

Identification of Long Noncoding RNA Associated with Osteoarthritis in Humans

Xing

Liang

et al. 2014

Orthopaedic Surgery

123

105

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Section: Discussionsupporting

confidence: 93%

Identification of Long Noncoding RNA Associated with Osteoarthritis in Humans

Xing

Liang

et al. 2014

Orthopaedic Surgery

123

105

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“…Several clinical and animal studies provided evidence suggesting that Twotooth Achyranthes Root, Chinese Angelica, Salviae Miltiorrhizae, Safflower and White Peony Root can promote the flow of Qi (vital energy) and blood, and can reduce swelling, remove blood stasis, and bring more nutrients and oxygen to healing tissue (Huang et al , 2014; Lin et al , 2005; Liu et al , 2013; Luo et al , 2013; Magdalou et al , 2015; Wei et al , 1999; Weng et al , 2014; Xie et al , 2001; Zhou et al , 2013). …”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medications for Knee Osteoarthritis Pain: A Meta-Analysis of Randomized Controlled Trials

et al. 2016

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Traditional Chinese medication (TCM) has analgesic and anti-inflammatory effects in patients with knee osteoarthritis (OA). We conducted the first systematic review of the best quantitative and qualitative evidence currently available in order to evaluate the effectiveness of TCM in relieving pain in knee OA. A comprehensive literature search was conducted using three English and four Chinese biomedical databases from their inception through March 1, 2015. We included randomized controlled trials of TCM for knee OA with intervention durations of at least two weeks. The effects of TCM on pain and other clinical symptoms were measured with the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The total effectiveness rate, which was used to assess overall pain, physical performance and wellness, was also measured. Two researchers independently extracted data on study design, population characteristics, duration, intervention, outcomes, risk of bias, and primary results. We performed a random-effects meta-analysis when appropriate. We also explored factors that could explain the heterogeneity by conducting subgroup and meta-regression analyses. Twenty-three studies, totaling 2362 subjects, met the eligibility criteria. Treatments were formulated with an average of 8 Chinese herbs and were prescribed based on the traditional Chinese diagnostic method of syndrome differentiation. The mean treatment duration was seven weeks, with oral administration occurring one to three times a day. Compared with non-steroidal anti-inflammatory drugs and intra-articular hyaluronate injections, 18 of the studies showed significantly improved VAS pain scores (Mean Difference [MD] = 0.56; 95% confidence interval [CI], 0.18 to 0.94; p = 0.004), six of the studies showed significantly improved WOMAC pain subscale scores (MD = 2.23; 95% CI, 0.56 to 3.91; p = 0.009), and 16 of the trials showed significantly improved total effectiveness rates (risk ratio = 1.12; 95% CI, 1.05 to 1.19; p = 0.0003). In addition, TCM showed a lower risk of adverse events than standard western treatments. This evidence suggests that TCM is safe and effective for improving pain, function, and wellness in treatments of knee OA. However, there is inherent clinical heterogeneity (diverse TCM formulations, controls, and treatment regimens) among the included trials. Despite these limitations, the potential analgesic effects of TCM warrant further methodologically rigorous research to determine the clinical implications of TCM on pain management in knee OA.

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“…78 Weng et al 120 studied in rats the component of a plant used in traditional Chinese medicine for the treatment of OA, called Achyranthes bidentata polysaccharides (ABPS) and demonstrated activation of Wnt/β catenin pathway, they also used Western blot for Wnt4, Frizzled 2, β catenin. ABPS seems to have beneficial effects in patients with OA by inducing proliferation of chondrocytes 120 Cassuto et al followed proinflammatory cytokines, anabolic and catabolic pathways in patients following hip arthroplasty. They found increased levels of the anabolic molecules, including Wnt/β catenin, and transient and remodeling activities for Wnt inhibitor molecules (ex.…”

Section: Wnt Signaling Molecules Andmentioning

confidence: 99%

<p>Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update</p>

Nagy

Nagy-Finna

Popoviciu

et al. 2020

CIA

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Serum biomarkers of osteoarticular diseases have been in the limelight of current clinical research trends. Laboratory validation of defined and candidate biomarkers for both osteoarthritis and osteoporosis is of key importance for future decisional algorithms in the diagnosis, monitoring, and prognosis of these diseases. The current guidelines recommend the use of collagen degradation remnants, eg, CTX-I and CTX-II, in the complementary diagnosis of both osteoporosis and osteoarthritis. Besides the collagen degradation markers, enzymes that regulate bone and articular metabolism are useful in the clinical evaluation of osteoarticular pathologies. Along these, several other recommended and new nominee molecules have been recently studied. Wnts and Wnt-related molecules have a cardinal role in the bone-joint homeostasis, making them a promising target not only for pharmaceutical modulation, but also to be considered as soluble biomarkers. Sclerostin and dickkopf, two inhibitor molecules of the Wnt/β-catenin signaling, might have a dual role in the assessment of the clinical manifestations of the osteoarticular unit. In osteoarthritis, besides fragments of collagen type II many pathway-related molecules have been studied and proposed for biomarker validation. The most serious limitation is that a significant proportion of studies lack statistical power due to the reduced number of cases enrolled. Serum biomarkers of bone and joint turnover markers represent an encouraging possibility for the diagnosis and prognosis of osteoarticular diseases, although further studies and laboratory validations should be carried out as to solely rely on them.

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Achyranthes bidentata polysaccharides activate the Wnt/β-catenin signaling pathway to promote chondrocyte proliferation

Cited by 53 publications

References 25 publications

Identification of Long Noncoding RNA Associated with Osteoarthritis in Humans

Identification of Long Noncoding RNA Associated with Osteoarthritis in Humans

Traditional Chinese Medications for Knee Osteoarthritis Pain: A Meta-Analysis of Randomized Controlled Trials

<p>Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update</p>

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