Achromobacter xylosoxidans Corneal Ulcer in a Therapeutic Soft Contact Lens Wearer

Fiscella, Richard G.; Noth, James

doi:10.1097/00003226-198912000-00008

Cited by 26 publications

(13 citation statements)

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“…28,29 A limited number of Achromobacter corneal infections have been reported and are characterized as slow progressing recurrent infections, associated with a localized infiltration that can progress to cause corneal ulcers. [30][31][32] Achromobacter maintains resistance to aminoglycosides, first generation cephalosporins, and variable susceptibility to fluoroquinolones. 32 Notably, these antibiotics are included in the regimen for treatment of eye infections that lack an identified causative organism (Bacterial Keratitis PPP, 2011, American Academy of Ophthalmology).…”

Section: Discussionmentioning

confidence: 99%

Bacterial Biofilm Diversity in Contact Lens-Related Disease: Emerging Role ofAchromobacter,Stenotrophomonas, andDelftia

Wiley

Bridge

Odom

et al. 2012

Invest. Ophthalmol. Vis. Sci.

100

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PURPOSE. Multi-species biofilms associated with contact lens cases and lenses can predispose individuals to contact lensrelated inflammatory complications. Our study used cultureindependent methods to assess the relationship between the severity of contact lens-related disease and bacteria residing in biofilms of contact lens cases and lenses.METHODS. Contact lens cases and lenses from 28 patients referred to the West Virginia University Eye Institute and diagnosed as having mild keratitis, keratitis with focal infiltrates, or corneal ulcers were processed and evaluated for bacterial composition based on 16S ribosomal RNA gene sequencing. Cases and lenses from nine asymptomatic contact lens wearers were processed in a manner similar to controls. Relationships between disease severity, bacterial types, and bacterial diversity were evaluated statistically.RESULTS. Disease severity and presenting visual acuity correlated with an increase in the diversity of bacterial types isolated from contact lens cases. A significant difference also was observed in the number of bacterial types associated with the three clinical groups. Achromobacter, Stenotrophomonas, and Delftia were prevalent in all disease groups, and Achromobacter and Stenotrophomonas were present in one asymptomatic control. Scanning electron microscopy revealed that Achromobacter and Stenotrophomonas formed a biofilm on the surface of contact lenses.CONCLUSIONS. Culture-independent methods identified an association between disease severity and bacterial diversity in biofilms isolated from cases and lenses of patients with contact lens-related corneal disease. Achromobacter, Stenotrophomonas, and Delftia were predominant bacteria identified in our study, drawing attention to their emerging role in contact lensrelated disease. (Invest Ophthalmol Vis Sci. 2012;53:3896-3905)

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Section: Discussionmentioning

confidence: 99%

Bacterial Biofilm Diversity in Contact Lens-Related Disease: Emerging Role ofAchromobacter,Stenotrophomonas, andDelftia

Wiley

Bridge

Odom

et al. 2012

Invest. Ophthalmol. Vis. Sci.

100

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“…A. xylosoxidans has been isolated in cases of ear and eye infections (26,28,30), urinary tract infections (28,38), intra-abdominal infections (39), liver abscesses (4), soft tissue infections (5, 29), osteomyelitis (42), arthroplasty infections (37), meningitis (8,26,29,30), ventriculitis (35), endocarditis (1, 2, 41), and pneumonia (3, 10-13, 20, 32, 34, 39, 44). A. xylosoxidans has been isolated from multiple sources, including blood (3,9,11,16,18,28,33), cerebrospinal fluid (CSF) (8,26,29,30), stool, urine (28,38), sputum (40), skin, ear discharge (29,45), wounds (29), abscesses (4, 39), bone (42), joints (37), endocardium (1, 2, 41), ascites fluid (39), and corneal scrapings and vitreous humor fluid (14,22,27,31).…”

Section: Case Reportmentioning

confidence: 99%

Achromobacter xylosoxidans Infection Presenting as a Pulmonary Nodule Mimicking Cancer

et al. 2011

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“…Além disso, há raros casos de úlcera de córnea ocasionada por esta bactéria em pacientes que usam lentes de contato macias (5) . Achromobacter está relacionado com essa infecção, porém é muito confundido com Pseudomonas aeruginosa, bactéria habitualmente associada à contaminação de produtos para lentes de contato (6) .…”

Section: Discussionunclassified

“…Uma diferença importante entre esses microrganismos refere-se ao seu comportamento frente aos antimicrobianos. Achromobacter é geralmente sensível à carbenicilina, cefalosporinas de terceira geração, imipenem e sulfametoxazol-trimetoprim (7) e resistente aos aminoglicosídeos, cefalosporinas de primeira e segunda geração, cloranfenicol e fluoroquinolonas (5) . Estudos mais recentes mostram que a bactéria pode não responder adequadamente à terapia antibiótica convencional com piperacilina ou ceftazidima (cefalosporina de terceira geração), sendo de difícil erradicação, implicando em necessidade de intervenção cirúrgica (ceratoplastia) (8) .…”

Section: Discussionunclassified

Conjuntivite por Achromobacter xylosoxidans: relato de caso

Lucatelli¹,

Cantarelli²,

Picoli³

2009

Arq. Bras. Oftalmol.

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Achromobacter xylosoxidans Corneal Ulcer in a Therapeutic Soft Contact Lens Wearer

Cited by 26 publications

References 0 publications

Bacterial Biofilm Diversity in Contact Lens-Related Disease: Emerging Role ofAchromobacter,Stenotrophomonas, andDelftia

Bacterial Biofilm Diversity in Contact Lens-Related Disease: Emerging Role ofAchromobacter,Stenotrophomonas, andDelftia

Achromobacter xylosoxidans Infection Presenting as a Pulmonary Nodule Mimicking Cancer

Conjuntivite por Achromobacter xylosoxidans: relato de caso

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