Achromobacter Septicemia—Fatalities in Prematures

In vitro susceptibility of Alcaligenes denitrificans subsp. xylosoxidans to 24 antimicrobial agents

“…xylosoxidans are scarce. The multiresistance pattern of susceptibility of this organism to several antibiotics has been emphasized in previous reports (2,3,5,6,10,15,20,22,24 (20). Reference strain ATCC 27061 was also included in the study.…”

“…A. denitrificans subsp. xylosoxidans has been isolated from various environmental and hospital water sources (6,9,10) and also from clinical specimens, including ear discharge, blood, cerebrospinal fluid, wound, peritoneal fluid, urine, stool, throat, sputum, and tracheal aspirate specimens (21). In many instances of isolation, this organism is considered as a colonizer and a potential pathogenic role is generally dismissed.…”

“…However, well-documented infections have been reported on several occasions. These include neonatal meningitis (16), ventriculitis after neurosurgery (22), fatal bacteremia (6,9,14,20), pneumonia (2,5,20,23), urinary tract infections (10), peritonitis (15,20), aortic root graft infection (18), endocarditis (13), and otitis externa (19). Nosocomial outbreaks usually associated with an aqueous source (usually nonbacteriostatic saline or hemodialysis fluid) have also been described (14,20).…”

“…Unsupplemented MuellerHinton broth was used in the microdilution trays. The trays were sealed in plastic bags and stored frozen at -20°C for a maximum of 6 weeks. Amoxycillin-clavulanic acid concentrations used were in a 2:1 proportion.…”

Source ofPseudomonas aeruginosainfection in premature infants

“…Most reports of outbreaks caused by Gram-negative bacilli in premature-baby wards have indicated that oxygen equipment, mechanical mucus aspirators (Rogers, 1960;Becker, 1962;Kresky, 1964;Bassett, Thompson & Page, 1965) or the humidifying water of incubators (Sever, 1959;Foley, Gravelle, Englehard & Chin, 1961) are the most likely reservoirs of infection. Other sources of these organisms are water taps, faucet aerators and sink traps.…”