Achiral and chiral high-performance liquid chromatographic methods for clinafloxacin, a fluoroquinolone antibacterial, in human plasma

Brodfuehrer, Joanne; Priebe, Stephen R.; Guttendorf, Robert

doi:10.1016/s0378-4347(98)00078-4

Cited by 20 publications

(7 citation statements)

References 5 publications

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“…HPLC methods using a crown ether-based CSP were successfully developed for fluoroquinolones containing a primary amino functional group [149]. For example, Brodfuehrer et al [117] and Lee et al [150] used a commercially available crown ether-coated Crownpack CR (+) column for the separation of CLI and GEM mesylate enantiomers, respectively. However, the resolved enantiomers have long retention times in both methods, making them unsuitable in terms of analytical run times.…”

Section: Chromatographic Separationmentioning

confidence: 99%

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

et al. 2012

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Fluoroquinolones are one of the most promising and intensively studied drugs of contemporary anti-infective chemotherapy. New fluoroquinolone antibacterials with improved pharmacokinetic properties and a broad spectrum of activity have been developed, opening new windows of opportunity for clinical use. To our knowledge, no comprehensive and critical review of the analytical methods for the determination of these agents, which correspond to the third- and fourth-generation quinolones, has yet been published. This work summarizes for the first time most of the liquid chromatographic methods reported in the literature for the separation and quantification of the new fluoroquinolones in biological matrices and pharmaceutical formulations. A systematic and detailed survey of physicochemical properties, sample preparation procedures, and chromatographic and detection conditions is presented herein. In the course of this review several liquid chromatographic methods are discussed: reversed-phase high-performance liquid chromatography (RP-HPLC), ion-exchange high-performance liquid chromatography (IEX-HPLC), hydrophilic interaction liquid chromatography (HILIC), high-performance thin-layer chromatography (HPTLC) and other chiral chromatographic methods. Their advantages, applicability and limitations are also examined.

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Section: Chromatographic Separationmentioning

confidence: 99%

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

et al. 2012

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“…The commercial crown ether CSP (Crownpak CR) has been employed by Brodfuehrer et al. for the determination of clinafloxacin enantiomers in human plasma. This CSP has also been used by Lee and Hong to separate enantiomers of gemifloxacin mesylate .…”

Section: Chiral Resolution By Hplcmentioning

confidence: 99%

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

2017

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The quinolones are derivatives of oxoquinolines and mostly known for their antibacterial and antiviral activities. Many quinolones are chiral compounds having asymmetric centers and important due to their enantioselective biological activities. In order to study the biological activities of quinolone enantiomers, to control the manufacturing of homochiral drugs and to prepare necessary quantities of pure enantiomers for preclinical or clinical trials, respective chiral separation methods are urgently needed. In this context, the present review discusses chromatographic and electrophoretic methods for the enantioseparation of chiral quinolones and provides some useful information on their physical and pharmaceutical properties. The drawbacks of currently used techniques are revealed and ways to overcome them are outlined. Moreover, recommendations for an optimal choice of a separation protocol are given.

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“…24,25 Pirkle DNBL chiral stationary phase operating in the reversed-phase mode has been used to investigate the metabolism of racemic cholecystokinin-B antagonists. 26 Occasionally, other chiral stationary phases have been used, such as crown ether (Crownpak CR (+)), which has been employed for analysis of clinafloxacin in human plasma, 27 or Chiralpak WE, which operates by the ligand exchange principle, used in studies on the stereoselective pharmacokinetics of RS-8359, a monoaminoxidase A inhibitor, chemically known as ()-4-(4-cyanoanilino-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]pyrimidine. 28 Among CSPs that have found widespread application in the bioanalysis of numerous drugs and their metabolites we should mention CSPs based on cellulose or amylose derivatives adsorbed on macroporous silica gel.…”

Section: Applications Of Stereoselective Chromatography In Clinical Pmentioning

confidence: 99%

Recent applications of stereoselective chromatography

2002

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Achiral and chiral high-performance liquid chromatographic methods for clinafloxacin, a fluoroquinolone antibacterial, in human plasma

Cited by 20 publications

References 5 publications

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

Recent applications of stereoselective chromatography

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