Achieving Ultralow Fouling under Ambient Conditions via Surface-Initiated ARGET ATRP of Carboxybetaine

Hong, Daewha; Hung, Hsiang‐Chieh; Wu, Kan; Lin, Xiaojie; Sun, Fang; Zhang, Peng; Liu, Sijun; Cook, Keith E.; Jiang, Shaoyi

doi:10.1021/acsami.7b01530

Cited by 85 publications

(79 citation statements)

References 30 publications

(53 reference statements)

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“…Different strategies are employed for creating such antifouling coatings, including functional self‐assembled monolayers (SAMs), polymer layers by “grafting‐to” methods, and polymer brushes by “grafting‐from” methods . For example, oligo(ethyleneglycol)‐terminated alkyl SAMs are able to resist or decrease fouling from single‐protein solutions .…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, neither of these approaches is able to fully prevent fouling from complex biological matrices such as blood plasma or serum . In contrast, polymer brushes created by grafting‐from methods have demonstrated remarkable resistance to biofouling from complex biological matrices, especially those based on zwitterionic polymers, such as polycarboxybetaines based on the corresponding methacrylate/amide (CBMA), polysulfobetaines from their methacrylate/amide precursor (SBMA), but also formally uncharged polymer brushes derived from N ‐(2‐hydroxypropyl) methacrylamide (HPMA) …”

Section: Introductionmentioning

confidence: 99%

“…However, SI‐ATRP is a thermal reaction that requires a rigorous control over oxygen‐free reaction conditions, which makes the reaction difficult to scale up and only provides uniform coatings. In response, new and easy‐to‐use approaches toward versatile polymer brush coatings were developed, such as activator regenerated by electron transfer (ARGET) and initiators for continuous activator regeneration (ICAR) . In addition, light‐induced polymerizations have been developed, so as to allow spatial and temporal control over the surface coating .…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Kuzmyn

Nguyen

Zuilhof

et al. 2019

Adv Materials Inter

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Hierarchical bioactive surfaces are created by visible‐light‐induced surface‐initiated living radical polymerization employing tris[2‐phenylpyridinato‐C2,N]iridium(III) as a photocatalyst. The hierarchical antifouling diblock copolymer structures consist of N‐(2‐hydroxypropyl)‐methacrylamide (first block) and carboxybetaine methacrylate (second block). The living nature of the polymerization is shown by a linear increase in layer thickness (as measured by atomic force microscopy) and reinitiation of the polymerization to create a patterned second block of polymer. The chemical structure of the brushes is confirmed by X‐ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy measurements. The block copolymer brushes demonstrate excellent antifouling properties when exposed to single‐protein solutions or to bovine serum. The second carboxybetaine block of the hierarchical antifouling structures can effectively be biofunctionalized with an anti‐fibrinogen antibody. The coated surfaces show a high affinity and specificity to fibrinogen, while preventing nonspecific adsorption from other proteins in bovine serum.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Kuzmyn

Nguyen

Zuilhof

et al. 2019

Adv Materials Inter

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“…Besides, the team of Jiang studied the incorporation of zwitterionic functionality into polyurethanes, such as the modification of segmented polyurethane with cross-linked sulfobetaine methacrylate polymer [ 43 ]. Moreover, Jiang et al modified materials surface with zwitterionic carboxybetaine copolymers [ 44 , 45 ] and fabricated tube of zwitterionic hydrogels [ 46 ]. These studies all revealed that zwitterionic component could effectively resist non-specific adhesion and shows great promise for blood-contacting devices.…”

Section: Introductionmentioning

confidence: 99%

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

Cai

et al. 2020

Regenerative Biomaterials

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Polyurethanes are widely used in interventional devices due to the excellent physicochemical property. However, non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices. Herein, a novel phospholipid-based polycarbonate urethanes (PCUs) were developed via two-step solution polymerization by direct synthesis based on functional raw materials. Furthermore, PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling surface. The results of stress–strain curves exhibited excellent tensile properties of PCUs films. Differential scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender, leading to different biological response. In vitro blood compatibility tests including bovine serum albumin adsorption, fibrinogen adsorption and denaturation, platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs samples. Endothelial cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ability. Finally, animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and histocompatibility. These results high light the strong anti-adhesion property of phospholipid-based PCUs films, which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future.

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“…A copper bromide catalyst in the solution controls the rate of polymerization from the surface to generate covalently grafted polymer brushes of uniform molecular weight and densely grafted surface. 108,109 Further, the thickness of the polymer brushes can be easily tailored by altering polymerization times. 73 Zwitterionic polymers generated using this technique have shown excellent resistance to nonspecific protein adsorption.…”

Section: Zwitterionic Polymer Fabricationmentioning

confidence: 99%

Engineering surfaces using photopolymerization to improve cochlear implant materials

Leigh¹

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my success as a graduate student. His dedication to my success in research and development as a professional have been constant and indispensable to my career. Dr. Guymon has helped me to substantially improve my technical communication skills, both writing and presenting, by providing invaluable feedback on manuscripts and presentations. He also provided me with a great undergraduate research experience for a summer as an REU student. Dr. Guymon's ambitious attitude is infectious and encouraged me to present my research and network with professionals from science and engineering. Dr. Marlan Hansen has also been an excellent mentor and collaborator during my graduate school experience. His contribution to the research project and this work have been significant and indispensable. I have enjoyed his optimism and creativity in meeting the challenges associated with graduate school. I am so grateful for his attitude and humor through stressful times and his willingness to mentor me individually, both professionally and personally. More could be said about his influence and guidance on my graduate school experience but suffice it to say that I am profoundly grateful for his mentorship. There have also been many outstanding members from Dr. Hansen's research lab who were invaluable to the project. Linjing

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Achieving Ultralow Fouling under Ambient Conditions via Surface-Initiated ARGET ATRP of Carboxybetaine

Cited by 85 publications

References 30 publications

Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

Engineering surfaces using photopolymerization to improve cochlear implant materials

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