Limited literature exists to explain why the masses comply or do not comply with orders from separatist groups. In this study, the researchers used variables from frustration-aggression theory, cognitive dissonance theory, and theory of fear to suggest a model that explains why operators of micro, small and medium enterprises comply with messages from Indigenous People of Biafra. The researchers made use of a descriptive survey research design with a structured questionnaire as the instrument for data collection. A total of 470 participants who were sampled using respondent-driven sampling chain referrals took part in the study. Results from the structural equation model analysis showed that predictors of compliance to Indigenous People of Biafra sit-at-home order among micro, small and medium enterprises operators include perceived injustice, believe in government as well as believe in Biafra agitation. Additional results showed that fear and information cues moderate this relationship. Recommendations are made based on the outcome of the study. The result of this study could inform policies on how to communicate messages aimed at addressing issues that have the potential of fuelling separatist agitations.