Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent

Osmokrović, Andrea; Jančić, Ivan; Vunduk, Jovana; Petrović, Predrag; Milenković, Marina; Obradović, Bojana

doi:10.1016/j.carbpol.2018.05.045

Cited by 32 publications

(15 citation statements)

References 36 publications

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“…The higher swelling is attributed to ionic carboxylate groups in the backbone, mainly due to the protonation of carboxylic acids in the polysaccharide (Sun & Tan, 2013). Outstanding properties of alginate materials include their ability of undergoing in situ gelation (Axpe & Oyen, 2016), water solubility (Rhim, 2004), cytocompatibility (Gonzalez-Pujana, Orive, Pedraz, Santos-Vizcaino, & Hernandez, 2018;Klöck et al, 1997;, mucoadhesive nature (Gonzalez-Pujana et al, 2018), prolonged release of active agents (Gombotz & Wee, 1998;Osmokrovic et al, 2018;Stockwell, Davis, & Walker, 1986) and protective barrier for cell and particle release systems (Leijs et al, 2016;Qi et al, 2012;Qiu et al, 2017). Thus, alginate hydrogels can be used for a wide range of applications such as drug carriers (Guan et al, 2018;Kurczewska et al, 2017), wound dressing (Rezvanian, Amin, & Ng, 2016), matrices for periodontal application (Gruskin, Doll, Futrell, Schmitz, & Hollinger, 2012), arthroscopic applications (Su, Liu, & Yeh, 2017), etc.…”

Section: Alginate Hydrogelsmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

383

209

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This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.

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Section: Alginate Hydrogelsmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

383

209

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“…Thus, it could be assumed that the initial bacterial reduction in the suspension was due to adsorption on AC surfaces as it was also reported in literature [28]. However, AC by itself does not affect bacteria so that they continued to multiply and eventually detached the AC surfaces [44]. So, in order to establish a long-term antibacterial effect, the presence of an antibacterial substance was necessary.…”

Section: Discussionmentioning

confidence: 83%

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Osmokrović¹,

Jančić²,

Janković-Čaštvan³

et al. 2019

Hem Ind

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Composites based on Zn-alginate hydrogels in the form of beads were produced by extrusion of a suspension containing 0.5 % w/w of alginate and 20 % w/w of activated charcoal (AC) with the intent to simultaneously release two active agents, Zn 2+ and AC particles, in a physiological-like environment. The obtained composite beads were analyzed by FE-SEM and characterized regarding textural parameters, as well as Zn 2+ and AC release kinetics in the physiological saline solution. Zn 2+ ions were quickly released reaching the equilibrium concentration within the first hour in the contrary to the release of AC particles, which was described by internal diffusion with the apparent diffusion coefficient of approximately 10-13 m 2 s-1. Potential functionality of the obtained beads was evaluated regarding antibacterial activity in suspensions of the standard bacterial strain Escherichia coli 25922. The observed strong bactericidal effects were related to the quick release of Zn 2+ that was not affected by AC. Thus, taking into account results of this study, as well as high sorption capacity of alginate hydrogel, efficiency of AC to adsorb malodor and tissue degradation products and positive effects of Zn 2+ on wound healing, the obtained composites have shown promising potentials for applications as multifunctional wound dressings.

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“…However, given that Ag ions have been proven to be highly toxic, wound healing is often delayed. Thus, modified chitosan or chitosan derivatives and new alginate‐based antibacterial hydrogels dressings have attracted increased research attention …”

Section: Methodsmentioning

confidence: 99%

“…Thus, modified chitosan or chitosan derivatives and new alginate-based antibacterial hydrogels dressings have attracted increased research attention. [9][10][11][12][13] Despite the advancements and the wide range of dressings available, wound management remains extremely challenging because of the susceptibility of a wound to bacterial infection. [14] Especially, diagnosis of bacterial infection is not straightforward and speed of detection is essential in clinical conditions.…”

mentioning

confidence: 99%

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

et al. 2020

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Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. In this work, trithiophene aldehyde (3T‐CHO) as a new photosensitizers was isolated from Herba Ecliptae, and tryptophan (Trp) modified 3T‐CHO improve water solubility and reduced phototoxicity. The photosensitizer‐loaded vesicles were incorporated into a gel scaffold to obtain a wound dressing with detection and antibacterial function. Detection of the presence of pathogenic bacteria, such as Pseudomonas aeruginosa, based on the fluorescence signals was highly efficient and sensitive. The cytotoxin produced by the pathogenic bacteria to induce vesicle lysis, thereby the photosensitive antibacterial agent was released from the vesicle to realize the simultaneous intelligent detection and treatment of pathogenic bacteria. Compared with traditional dressings coated with antibiotics, the synthesized dressing avoids the drawback of pathogenic bacteria developing drug resistance. The proposed microbiologically responsive wound dressing could be used as a general methodology for the design and fabrication of bacterium‐responsive functional biomaterials.

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Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent

Cited by 32 publications

References 36 publications

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

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