Achievement of take-home dose privileges is associated with better-perceived sleep and with cognitive status among methadone maintenance treatment patients

Peles, Einat; Schreiber, Shaul; Domany, Yoav; Sason, Anat; Tene, Oren; Adelson, Miriam

doi:10.3109/15622975.2014.897003

Cited by 12 publications

(13 citation statements)

References 32 publications

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“…Previous studies investigating sleep problems among heroin users have often used self-reported questionnaires such as the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale. 36 , 37 However, heroin users may not seek medical assistance. In order to provide another point of view, we used CPSD as the primary outcome.…”

Section: Discussionmentioning

confidence: 99%

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Li¹,

Chung²,

Wu³

et al. 2018

NDT

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IntroductionSleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT.MethodsThis 2-year retrospective study included 152 individuals (127 males and 25 females) with heroin use disorder who visited our MMT clinics for the first time. A univariate Cox proportional hazards regression model (Cox model) was used to estimate the potential factors of subsequent CPSD, followed by a multivariate Cox model to identify significant predictors of CPSD after adjusting for other covariates.ResultsTwenty-nine (19.1%) participants developed CPSD during the 2-year period. After forward selection in the Cox model, earlier age at onset of heroin exposure (OR=0.95; P=0.044), lower attendance rate (OR =0.04; P=0.03), greater maximum dose of methadone (OR =1.01; P=0.022), and shorter time to maximum methadone dose (OR =0.98; P=0.007) were significantly associated with new-onset CPSD.ConclusionWe identified predictors that were significantly associated with new-onset CPSD, and clinicians should be aware of sleep disturbance in heroin users receiving MMT with these risk factors. Future studies are necessary to verify our findings and extend the applicability.

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Section: Discussionmentioning

confidence: 99%

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Li¹,

Chung²,

Wu³

et al. 2018

NDT

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“…70.2% of patients had PSQI scores >5 in a 121 heroin addicts who were receiving MMT sample [ 16 ], compared with those methadone maintenance treatment (MMT) patients who had history of longer duration of opiate usage and a shorter period in MMT with no methadone take-home doses (THD) (80.6%, PSQI > 5). MMT patients who had two weeks achievement of THD showed lower rates of poor sleep (56%, PSQI > 5) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Duration of substance abuse may have impact on quality of sleep. Peles E found that subjects with a longer duration of opiate usage had poorer sleep [ 17 ]. Pasch KE Found a longitudinal bi-directional relationships between sleep quality and addictive substance use (such as cigarettes, alcohol or marijuana) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Sleeping problems in Chinese illicit drug dependent subjects

Tang

Liao

et al. 2015

BMC Psychiatry

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BackgroundIllicit drug use/dependence has been recognized as a major problem. Clinical studies demonstrate that poor sleep quality is associated with increased frequency of drug use and relapse. However, few studies have addressed the issue of sleep quality among illicit drug dependent subjects.MethodsThis cross-sectional study explored sleep quality in drug dependent subjects in China. We studied 2178 illicit drug dependent subjects from drug rehabilitation centres in Changsha and 2236 non-drug-using subjects, all of whom completed the self-report Pittsburgh Sleep Quality Index (PSQI).ResultsWe found that the prevalence of sleep disturbance was much higher in drug users (68.5%, PSQI >5; specifically, 80.24% in heroin users, 54.16% in methamphetamine users and 81.98% in ketamine users with PSQI >5) than non-users (26.4%, PSQI >5). Drug users had approximately twice the sleep latency than nondrug users (37.7 minutes V.S 18.4 minutes). Although drug users and non-users reported similar sleep duration (about 7.4 hours), drug users showed poorer subjective sleep quality and habitual sleep efficiency. They reported more sleep disturbance and need for sleep medications, more daytime dysfunction and poorer subjective sleep quality compared with nondrug users. The total PSQI score positively correlated with the duration of drug use (rp = 0.164, p < 0.001). We also found a link between sleep problems and cigarette smoking, alcohol drinking, and duration of drug use.ConclusionsPoor sleep quality is common among illicit drug dependent subjects. Long-term substance users had more sleep problems. Future research aiming at quantifying the benefits of treatment interventions should not neglect the influence of sleep problems. Gaining more insight into the impact of sleep quality on the addiction treatment could also help to target future intervention measures more effectively.

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“…One of our participants described her practice of self-adjustment of her take-home methadone dose to allow her one full night of sleep per week. A study of the practice of allowing take-home doses by Peles et al (2014) showed that take-home doses were associated with better perception of sleep quality compared with those who did not receive take-home doses (56% vs. 80.6%, respectively). Recognizing the challenges that the COVID-19 pandemic presented regarding reducing face-to-face encounters, the U.S. Drug Enforcement Administration modified existing policy in January of 2020 to allow prescribers to prescribe Schedule II-IV controlled substances via telemedicine (Drug Enforcement Administration, 2020).…”

Section: Discussionmentioning

confidence: 99%

“It's Like Your Whole Body Hates You”

Gray¹,

Wilson²,

Landis³

et al. 2022

UJAN

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A qualitative descriptive study was conducted concurrent with a larger study investigating the effects of hyperbaric oxygen treatment on withdrawal symptoms for adults receiving daily methadone for opioid use disorder. The aims of this study were to (a) evaluate the perceptions of withdrawal symptoms and sleep characteristics of study participants and (b) explore the experiences of participation in the parent trial of hyperbaric oxygen treatment. Adults with opioid use disorder can experience distressing symptoms related to withdrawal as well as co-occurring symptoms; sleep impairment is frequently reported. Few studies have examined how adults who receive medication for opioid use disorder experience sleep. A preliminary study of adults receiving daily methadone found that withdrawal symptoms were improved after hyperbaric oxygen treatment. This study explores the narrative of opioid users who report their overall experiences with withdrawal and sleep as well as their experiences of hyperbaric therapy. A convenience sample of six participants was recruited, who represented a small subgroup of participants who completed the larger hyperbaric treatment study. Data were collected via semistructured interviews. Data were analyzed using the qualitative content analysis guidelines proposed by Schreier (2012). All participants described poor overall sleep hygiene and disturbed sleep. More than half of the respondents reported improved or eliminated withdrawal symptoms, and all reported improvement in sleep quality after participation in the sleep study. This companion study confirms that subjective sleep disturbance may be prevalent for adults with opioid use disorder. Participants felt the experience of hyperbaric oxygen treatment produced a positive effect on sleep.

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Achievement of take-home dose privileges is associated with better-perceived sleep and with cognitive status among methadone maintenance treatment patients

Abstract: Privileges that reflect patients' abstinence and rehabilitation were also expanded to be associated with better cognitive states. These finding confirm the THD dispensing performance. Including CDT as part of the decision for dispensing THD may be considered.

Cited by 12 publications

References 32 publications

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Sleeping problems in Chinese illicit drug dependent subjects

“It's Like Your Whole Body Hates You”

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