Acetylcholinesterase inhibitors for electroconvulsive therapy‐induced cognitive side effects: a systematic review

Abstract

Despite large heterogeneity in studies, Ache-I appear to have beneficial effects on ECT-induced cognitive side effects, supporting an association with the cholinergic system in ECT-induced cognitive impairment. Methodological sound studies controlling for putative confounders are warranted. Copyright © 2017 John Wiley & Sons, Ltd.

Knowledge and attitudes of older psychiatric patients and their caregivers towards electroconvulsive therapy

“…As Beijing Anding Hospital mainly serves patients with acute and severe psychiatric disorders, many patients with major depression have psychotic symptoms, which justified the high percentage of antipsychotic use in this study. The mean number of ECT sessions was 6.7 AE 2.3, which was in the lower range of the usual recommended number of sessions (6)(7)(8)(9)(10)(11)(12) in treatment guidelines in China. 24 One reason for the low number of treatments may be the poor general health of older patients, which reduces their ability to tolerate many ECT sessions.…”

“…Although the mechanism of ECT remains unclear, it is effective particularly for those who are unresponsive to pharmacotherapy or unable to tolerate medications . However, ECT can also result in adverse effects, such as transient memory impairment, which may restrict its use in older patients …”

“…3,4 However, ECT can also result in adverse effects, such as transient memory impairment, which may restrict its use in older patients. [5][6][7] The knowledge and attitudes of patients and their caregivers towards ECT could significantly influence its acceptance and use in clinical practice. 8,9 Misconceptions and negative attitudes towards ECT due to its inaccurate portrayal in mass media, irrational fears of electricity, and excessive fear of memory loss have often created controversy around ECT.…”

Prophylactic cognitive enhancers for improvement of cognitive function in patients undergoing electroconvulsive therapy

“…We analyzed more articles to evaluate the impacts of cognitive enhancers for ECT-induced cognitive side effects. [ 23 ]…”

Kognitive Defizite der Elektrokonvulsionstherapie bei Depressionen: Moderierende Variablen und neuropsychologische Testverfahren

“…Es werden verschiedene protektive Komedikationen erforscht, um die Ausprägung der kognitiven Nebenwirkungen gezielt zu minimieren oder deren Entstehung zu verhindern. Hierzu gehören unter anderem der NMDA-Rezeptorblocker Memantin [52], der μ-Opioid-Rezeptorblocker Naltrexon [53], Acetylcholine-Esterase-Inhbitoren [54] und Weihrauchextrakt [55]. Obwohl einzelne Berichte zu diesen Substanzen eine positive Wirkung nahelegen, wurden diese bisher nur selten repliziert, sodass zurzeit keine eindeutige Empfehlung möglich ist.…”